{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:02:03Z","timestamp":1791644523916,"version":"4.3.4"},"reference-count":62,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD084478"],"award-info":[{"award-number":["R01HD084478"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD101243"],"award-info":[{"award-number":["R01HD101243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD102170"],"award-info":[{"award-number":["R01HD102170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HD106485"],"award-info":[{"award-number":["P01HD106485"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Progesterone resistance, a known pathologic condition associated with a reduced cellular response to progesterone and heightened estrogen responses, appears to have a normal physiologic role in mammalian reproduction. The molecular mechanism responsible for progesterone resistance in normal and abnormal endometrium remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To examine the roles of sirtuin-1 (SIRT1) in normal endometrium as well as endometrium associated with infertility and endometriosis, as an epigenetic modulator associated with progesterone resistance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>SIRT1 expression was examined by Western blot, quantitative real-time polymerase chain reaction, and immunohistochemistry in mouse uterus and human endometrium. Mice with uterine specific Sirt1 overexpression were developed to examine SIRT1\u2019s role in endometrial function and endometriosis development. EX-527, a SIRT1 inhibitor, and SRT1720, a SIRT1 agonist, were also used to evaluate SIRT1 effect on endometriosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In normal healthy women, endometrial SIRT1 is expressed only during menses. SIRT1 was dramatically overexpressed in the endometrium from women with endometriosis in both the epithelium and stroma. In mice, SIRT1 is expressed at the time of implantation between day 4.5 and 5.5 of pregnancy. Overexpression of SIRT1 in the mouse uterus leads to subfertility due to implantation failure, decidualization defects and progesterone resistance. SIRT1 overexpression in endometriotic lesions promotes worsening endometriosis development. EX-527 significantly reduced the number of endometriotic lesions in the mouse endometriosis model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SIRT1 expression and progesterone resistance appears to play roles in normal endometrial functions. Aberrant SIRT1 expression contributes to progesterone resistance and may participate in the pathophysiology of endometriosis. SIRT1 is a novel and targetable protein for the diagnosis as well as treatment of endometriosis and the associated infertility seen in this disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab753","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T22:28:12Z","timestamp":1634768892000},"page":"788-800","source":"Crossref","is-referenced-by-count":51,"title":["Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-5457","authenticated-orcid":false,"given":"Tae Hoon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5205-4495","authenticated-orcid":false,"given":"Steven L","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-1915","authenticated-orcid":false,"given":"Tsutomu","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Sakyo-ku, Kyoto, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L","family":"Deaton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wake Forest Baptist Health, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P","family":"Schammel","sequence":"additional","affiliation":[{"name":"Pathology Associates, Prisma Health System, Greenville, SC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilder Alberto","family":"Palomino","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Research, Reproductive Medicine and Infertility Unit, University of Chile & Department of Obstetrics and Gynecology, San Borja Arriar\u00e1n Clinical Hospital, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5368-6478","authenticated-orcid":false,"given":"Jae-Wook","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8451-2817","authenticated-orcid":false,"given":"Bruce A","family":"Lessey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wake Forest Baptist Health, Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"issue":"4","key":"2022021713152359200_CIT0001","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1210\/er.2018-00242","article-title":"Endometriosis","volume":"40","author":"Bulun","year":"2019","journal-title":"Endocr Rev"},{"issue":"25","key":"2022021713152359200_CIT0002","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Clinical practice. Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N Engl J Med."},{"issue":"6","key":"2022021713152359200_CIT0003","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/aogs.13156","article-title":"Progesterone resistance in endometriosis: origins, consequences and interventions","volume":"96","author":"Patel","year":"2017","journal-title":"Acta Obstet Gynecol Scand."},{"issue":"1-2","key":"2022021713152359200_CIT0004","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mce.2005.11.041","article-title":"Progesterone resistance in endometriosis: link to failure to metabolize estradiol","volume":"248","author":"Bulun","year":"2006","journal-title":"Mol Cell Endocrinol."},{"issue":"3","key":"2022021713152359200_CIT0005","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1471-0528.1998.tb10098.x","article-title":"Progesterone resistance in women who have had breast cancer","volume":"105","author":"Simpson","year":"1998","journal-title":"Br J Obstet Gynaecol."},{"issue":"11","key":"2022021713152359200_CIT0006","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1210\/mend.11.11.0006","article-title":"Biphasic regulation of breast cancer cell growth by progesterone: role of the cyclin-dependent kinase inhibitors, p21 and p27(Kip1)","volume":"11","author":"Groshong","year":"1997","journal-title":"Mol Endocrinol."},{"issue":"2","key":"2022021713152359200_CIT0007","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2011.10.035","article-title":"Mechanisms of endometrial progesterone resistance","volume":"358","author":"Al-Sabbagh","year":"2012","journal-title":"Mol Cell Endocrinol."},{"issue":"1","key":"2022021713152359200_CIT0008","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mce.2010.08.006","article-title":"Inflammatory pathways in endometrial disorders","volume":"335","author":"Maybin","year":"2011","journal-title":"Mol Cell Endocrinol."},{"issue":"1","key":"2022021713152359200_CIT0009","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1038\/s41598-017-04577-w","article-title":"KRAS Activation and over-expression of SIRT1\/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance","volume":"7","author":"Yoo","year":"2017","journal-title":"Sci Rep."},{"issue":"10-12","key":"2022021713152359200_CIT0010","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.semcdb.2013.08.004","article-title":"Role of nuclear receptors in blastocyst implantation","volume":"24","author":"Vasquez","year":"2013","journal-title":"Semin Cell Dev Biol."},{"issue":"12","key":"2022021713152359200_CIT0011","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med."},{"issue":"1-2","key":"2022021713152359200_CIT0012","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mce.2011.10.028","article-title":"The progesterone receptor regulates implantation, decidualization, and glandular development via a complex paracrine signaling network","volume":"357","author":"Wetendorf","year":"2012","journal-title":"Mol Cell Endocrinol."},{"issue":"2","key":"2022021713152359200_CIT0013","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.semcdb.2007.12.001","article-title":"In vivo analysis of progesterone receptor action in the uterus during embryo implantation","volume":"19","author":"Franco","year":"2008","journal-title":"Semin Cell Dev Biol."},{"issue":"3","key":"2022021713152359200_CIT0014","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1210\/endo-125-3-1683","article-title":"Cell type-specific localization of c-myc protein in the mouse uterus: modulation by steroid hormones and analysis of the periimplantation period","volume":"125","author":"Huet-Hudson","year":"1989","journal-title":"Endocrinology."},{"issue":"1","key":"2022021713152359200_CIT0015","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1677\/joe.0.0560133","article-title":"Hypertrophy and hyperplasia in the mouse uterus after oestrogen treatment: an autoradiographic study","volume":"56","author":"Martin","year":"1973","journal-title":"J Endocrinol."},{"issue":"2","key":"2022021713152359200_CIT0016","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.mce.2011.07.027","article-title":"The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling","volume":"358","author":"Large","year":"2012","journal-title":"Mol Cell Endocrinol."},{"issue":"12","key":"2022021713152359200_CIT0017","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1210\/me.2013-1191","article-title":"COUP-TFII regulates human endometrial stromal genes involved in inflammation","volume":"27","author":"Li","year":"2013","journal-title":"Mol Endocrinol."},{"issue":"4","key":"2022021713152359200_CIT0018","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11154-012-9223-7","article-title":"Inflammation, leukocytes and menstruation","volume":"13","author":"Evans","year":"2012","journal-title":"Rev Endocr Metab Disord."},{"issue":"8","key":"2022021713152359200_CIT0019","first-page":"2897","article-title":"Progesterone receptor isoform A but not B is expressed in endometriosis","volume":"85","author":"Attia","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2022021713152359200_CIT0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2017.05.031","article-title":"Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why","volume":"108","author":"Lessey","year":"2017","journal-title":"Fertil Steril."},{"issue":"4","key":"2022021713152359200_CIT0021","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.fertnstert.2016.02.018","article-title":"Local and systemic factors and implantation: what is the evidence?","volume":"105","author":"Fox","year":"2016","journal-title":"Fertil Steril."},{"issue":"5","key":"2022021713152359200_CIT0022","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/path.1738","article-title":"Aberrations in the progesterone receptor gene and the risk of recurrent endometrial carcinoma","volume":"205","author":"Pijnenborg","year":"2005","journal-title":"J Pathol."},{"issue":"5","key":"2022021713152359200_CIT0023","first-page":"643","article-title":"Progestin therapy in endometriosis","volume":"11","author":"Gezer","year":"2015","journal-title":"Womens Health."},{"key":"2022021713152359200_CIT0024","doi-asserted-by":"crossref","first-page":"191967","DOI":"10.1155\/2014\/191967","article-title":"Medical treatments for endometriosis-associated pelvic pain","volume":"2014","author":"Zito","year":"2014","journal-title":"Biomed Res Int."},{"issue":"4","key":"2022021713152359200_CIT0025","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0042-6989(89)90011-4","article-title":"Comparison of saccadic eye movements in humans and macaques to single-step and double-step target movements","volume":"29","author":"Baizer","year":"1989","journal-title":"Vision Res."},{"issue":"1","key":"2022021713152359200_CIT0026","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.rbmo.2013.08.012","article-title":"Investigations into implantation failure in oocyte-donation recipients","volume":"28","author":"Barri","year":"2014","journal-title":"Reprod Biomed Online."},{"issue":"2","key":"2022021713152359200_CIT0027","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.rbmo.2010.04.026","article-title":"Endometriosis-associated infertility: surgery and IVF, a comprehensive therapeutic approach","volume":"21","author":"Barri","year":"2010","journal-title":"Reprod Biomed Online."},{"issue":"6","key":"2022021713152359200_CIT0028","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.fertnstert.2005.02.059","article-title":"Role of laparoscopic treatment of endometriosis in patients with failed in vitro fertilization cycles","volume":"84","author":"Littman","year":"2005","journal-title":"Fertil Steril."},{"issue":"2","key":"2022021713152359200_CIT0029","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/humupd\/dmq037","article-title":"Implantation failure: molecular mechanisms and clinical treatment","volume":"17","author":"Cakmak","year":"2011","journal-title":"Hum Reprod Update."},{"issue":"2","key":"2022021713152359200_CIT0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0002-9378(16)33500-1","article-title":"Dating the endometrial biopsy","volume":"122","author":"Noyes","year":"1975","journal-title":"Am J Obstet Gynecol."},{"issue":"2","key":"2022021713152359200_CIT0031","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/gene.20098","article-title":"Cre-mediated recombination in cell lineages that express the progesterone receptor","volume":"41","author":"Soyal","year":"2005","journal-title":"Genesis."},{"issue":"4","key":"2022021713152359200_CIT0032","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00125-013-3140-5","article-title":"Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice","volume":"57","author":"Sasaki","year":"2014","journal-title":"Diabetologia"},{"issue":"12","key":"2022021713152359200_CIT0033","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1093\/humrep\/dem312","article-title":"Menstrual-like changes in mice are provoked through the pharmacologic withdrawal of progesterone using mifepristone following induction of decidualization","volume":"22","author":"Xu","year":"2007","journal-title":"Hum Reprod."},{"issue":"474","key":"2022021713152359200_CIT0034","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf7533","article-title":"Loss of HDAC3 results in nonreceptive endometrium and female infertility","volume":"11","author":"Kim","year":"2019","journal-title":"Sci Transl Med"},{"issue":"10","key":"2022021713152359200_CIT0035","first-page":"5419","article-title":"Immunohistochemical analyses of estrogen receptor in endometrial adenocarcinoma using a monoclonal antibody","volume":"46","author":"Budwit-Novotny","year":"1986","journal-title":"Cancer Res."},{"issue":"7","key":"2022021713152359200_CIT0036","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1096\/fj.12-225664","article-title":"Signal transducer and activator of transcription-3 (Stat3) plays a critical role in implantation via progesterone receptor in uterus","volume":"27","author":"Lee","year":"2013","journal-title":"FASEB J."},{"issue":"3","key":"2022021713152359200_CIT0037","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1677\/joe.0.1000295","article-title":"Vascular and cellular changes in the decidualized endometrium of the ovariectomized mouse following cessation of hormone treatment: a possible model for menstruation","volume":"100","author":"Finn","year":"1984","journal-title":"J Endocrinol."},{"issue":"4","key":"2022021713152359200_CIT0038","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1677\/joe.0.0390593","article-title":"Patterns of cell division in the mouse uterus during early pregnancy","volume":"39","author":"Finn","year":"1967","journal-title":"J Endocrinol."},{"issue":"2","key":"2022021713152359200_CIT0039","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1677\/joe.0.1400239","article-title":"Inhibition of progesterone receptor function results in loss of basic fibroblast growth factor expression and stromal cell proliferation during uterine remodelling in the pregnant rat","volume":"140","author":"Rider","year":"1994","journal-title":"J Endocrinol."},{"issue":"1","key":"2022021713152359200_CIT0040","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1128\/MCB.26.1.28-38.2006","article-title":"Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage","volume":"26","author":"Solomon","year":"2006","journal-title":"Mol Cell Biol."},{"issue":"6","key":"2022021713152359200_CIT0041","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/dgd.12145","article-title":"Sirtuin inhibitor Ex-527 causes neural tube defects, ventral edema formations, and gastrointestinal malformations in Xenopus laevis embryos","volume":"56","author":"Ohata","year":"2014","journal-title":"Dev Growth Differ."},{"issue":"6390","key":"2022021713152359200_CIT0042","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/359076a0","article-title":"Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor","volume":"359","author":"Stewart","year":"1992","journal-title":"Nature."},{"issue":"24","key":"2022021713152359200_CIT0043","doi-asserted-by":"crossref","first-page":"11408","DOI":"10.1073\/pnas.88.24.11408","article-title":"Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation","volume":"88","author":"Bhatt","year":"1991","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"2022021713152359200_CIT0044","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1095\/biolreprod62.5.1285","article-title":"Blockade of the alpha(v)beta(3) integrin adversely affects implantation in the mouse","volume":"62","author":"Illera","year":"2000","journal-title":"Biol Reprod."},{"issue":"3","key":"2022021713152359200_CIT0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/22840265211018544","article-title":"Altered eutopic endometrial T-regulatory and T-helper 17 lymphocyte ratio in women with unexplained subfertility","volume":"13","author":"Adur","year":"2021","journal-title":"J Endometr Pelvic Pain Disord."},{"issue":"8","key":"2022021713152359200_CIT0046","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1210\/en.2006-1692","article-title":"Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis","volume":"148","author":"Burney","year":"2007","journal-title":"Endocrinology."},{"issue":"4","key":"2022021713152359200_CIT0047","doi-asserted-by":"crossref","first-page":"354.e1","DOI":"10.1016\/j.ajog.2018.12.039","article-title":"Clinical diagnosis of endometriosis: a call to action","volume":"220","author":"Agarwal","year":"2019","journal-title":"Am J Obstet Gynecol."},{"issue":"7","key":"2022021713152359200_CIT0048","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.tem.2018.04.001","article-title":"Progesterone receptor regulation of uterine adaptation for pregnancy","volume":"29","author":"Wu","year":"2018","journal-title":"Trend Endocrinol Metab"},{"issue":"2","key":"2022021713152359200_CIT0049","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1095\/biolreprod.116.144410","article-title":"Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment","volume":"96","author":"Wetendorf","year":"2017","journal-title":"Biol Reprod."},{"issue":"11","key":"2022021713152359200_CIT0050","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1210\/endo.140.11.7148","article-title":"Differential uterine expression of estrogen and progesterone receptors correlates with uterine preparation for implantation and decidualization in the mouse","volume":"140","author":"Tan","year":"1999","journal-title":"Endocrinology."},{"issue":"3","key":"2022021713152359200_CIT0051","doi-asserted-by":"crossref","first-page":"156","DOI":"10.2174\/157489008786263989","article-title":"A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases","volume":"3","author":"Pillarisetti","year":"2008","journal-title":"Recent Pat Cardiovasc Drug Discov."},{"issue":"15","key":"2022021713152359200_CIT0052","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1128\/MCB.01620-12","article-title":"STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6","volume":"33","author":"Walker","year":"2013","journal-title":"Mol Cell Biol."},{"issue":"5","key":"2022021713152359200_CIT0053","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/humrep\/dev050","article-title":"Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis","volume":"30","author":"Kim","year":"2015","journal-title":"Hum Reprod."},{"key":"2022021713152359200_CIT0054","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1478-811X-9-11","article-title":"Mammalian Sirt1: insights on its biological functions","volume":"9","author":"Rahman","year":"2011","journal-title":"Cell Commun Signal."},{"key":"2022021713152359200_CIT0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2017.01.022","article-title":"Caveolin1\/protein arginine methyltransferase1\/sirtuin1 axis as a potential target against endothelial dysfunction","volume":"119","author":"Charles","year":"2017","journal-title":"Pharmacol Res."},{"issue":"5","key":"2022021713152359200_CIT0056","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1080\/13543776.2017.1276565","article-title":"Selective histone deacetylase small molecule inhibitors: recent progress and perspectives","volume":"27","author":"Qin","year":"2017","journal-title":"Expert Opin Ther Pat."},{"issue":"3","key":"2022021713152359200_CIT0057","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1210\/jc.2014-3720","article-title":"Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization","volume":"100","author":"Su","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"issue":"6","key":"2022021713152359200_CIT0058","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1615\/CritRevOncog.2013010187","article-title":"Sirtuins in hematological aging and malignancy","volume":"18","author":"Roth","year":"2013","journal-title":"Crit Rev Oncog."},{"issue":"3","key":"2022021713152359200_CIT0059","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1517\/13543770902755111","article-title":"Sirtuin inhibitors","volume":"19","author":"Alca\u00edn","year":"2009","journal-title":"Expert Opin Ther Pat."},{"key":"2022021713152359200_CIT0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13148-016-0224-3","article-title":"Sirtuin functions and modulation: from chemistry to the clinic","volume":"8","author":"Carafa","year":"2016","journal-title":"Clin Epigenetics."},{"issue":"38","key":"2022021713152359200_CIT0061","first-page":"77","article-title":"Sirtuins: the future insight","volume":"10","author":"Suvarna","year":"2012","journal-title":"Kathmandu Univ Med J (KUMJ)."},{"issue":"13","key":"2022021713152359200_CIT0062","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.2174\/138945011798184155","article-title":"Cancer chemoprevention by targeting the epigenome","volume":"12","author":"Huang","year":"2011","journal-title":"Curr Drug Targets."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab753\/42149798\/dgab753.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/3\/788\/42544706\/dgab753.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/3\/788\/42544706\/dgab753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T13:19:08Z","timestamp":1645103948000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/3\/788\/6403385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":62,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,10,19]]},"published-print":{"date-parts":[[2022,2,17]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab753","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2021,10,19]]}}}