{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:22:21Z","timestamp":1761582141727,"version":"3.37.3"},"reference-count":51,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["UO1-AI-35004","UO1-AI-31834","UO1-AI-34994","UO1-AI-34989","UO1-AI-34993","UO1-AI-42590"],"award-info":[{"award-number":["UO1-AI-35004","UO1-AI-31834","UO1-AI-34994","UO1-AI-34989","UO1-AI-34993","UO1-AI-42590"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["UO1-HD-32632"],"award-info":[{"award-number":["UO1-HD-32632"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["UL1\u00a0RR024131"],"award-info":[{"award-number":["UL1\u00a0RR024131"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>It is not yet understood whether people living with HIV infection have an increased risk of Alzheimers Disease and Related Dementias due to enhanced survivorship with highly effective antiretroviral therapies and\/or increasing adiposity with aging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to determine whether body mass index (BMI) and leptin were longitudinally associated over 10 years with neuropsychological performance (NP) among middle-aged women with HIV (WWH) vs without HIV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women\u2019s Interagency HIV Study (WIHS) participants (301 WWH, 113 women without HIV from Brooklyn, New York City, and Chicago had baseline and 10-year BMI and fasting plasma leptin levels using commercial enzyme-linked immunosorbent assay (ng\/mL); and demographically adjusted NP T scores (attention\/working memory, executive function [EF], processing speed, memory, learning, verbal fluency, motor function, global) at 10-year follow-up. Multivariable linear regression analyses, stratified by HIV serostatus, examined associations between BMI, leptin, and NP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Over 10 years, women (baseline age 39.8\u2005\u00b1\u20059.2 years, 73% Black, 73% WWH) transitioned from average overweight (29.1\u2005\u00b1\u20057.9) to obese (30.5\u2005\u00b1\u20057.9) BMI. Leptin increased 11.4\u2005\u00b1\u200526.4 ng\/mL (P\u2005&amp;lt;\u2005.001). Higher baseline BMI and leptin predicted poorer 10-year EF among all women (BMI \u03b2\u2005=\u2005\u20136.97, 95% CI (\u201311.5 to \u20132.45) P\u2005=\u2005.003; leptin \u03b2\u2005=\u2005\u20131.90, 95% CI (\u20133.03 to \u20130.76), P\u2005=\u2005.001); higher baseline BMI predicted better memory performance (\u03b2\u2005=\u20056.35, 95% CI (1.96-10.7), P\u2005=\u2005.005). Greater 10-year leptin increase predicted poorer EF (P\u2005=\u2005.004), speed (P\u2005=\u2005.03), and verbal (P\u2005=\u2005.02) and global (P\u2005=\u20050.005) performance among all women, and WWH. Greater 10-year BMI increase predicted slower processing speed (P\u2005=\u2005.043) among all women; and among WWH, poorer EF (P\u2005=\u2005.01) and global (P\u2005=\u2005.04) performance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In middle-aged WIHS participants, 10-year increases in BMI and leptin were associated with poorer performance across multiple NP domains among all women and WWH. Trajectories of adiposity measures over time may provide insight into the role of adipose tissue in brain health with aging.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab759","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T13:19:20Z","timestamp":1634908760000},"page":"e1126-e1135","source":"Crossref","is-referenced-by-count":9,"title":["Body Mass Index and Leptin Are Related to Cognitive Performance Over 10 Years in Women With and Without HIV Infection"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0996-6245","authenticated-orcid":false,"given":"Francesca","family":"Macaluso","sequence":"first","affiliation":[{"name":"College of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M","family":"Weber","sequence":"additional","affiliation":[{"name":"Cook County Health\/Hektoen Institute of Medicine, Chicago, Illinois, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leah H","family":"Rubin","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Psychiatry, and Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Dellinger","sequence":"additional","affiliation":[{"name":"College of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Holman","sequence":"additional","affiliation":[{"name":"Department of Medicine\/STAR Program, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Minkoff","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA"},{"name":"Maimonides Hospital, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Keating","sequence":"additional","affiliation":[{"name":"GigaGen Medical Laboratory, San Francisco, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa R","family":"Merlin","sequence":"additional","affiliation":[{"name":"Department of Neurology, New York City Health and Hospitals\/Kings County, Brooklyn, New York, USA"},{"name":"Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-8560","authenticated-orcid":false,"given":"Deborah R","family":"Gustafson","sequence":"additional","affiliation":[{"name":"Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn, New York, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"issue":"11","key":"2022021713154853100_CIT0001","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1111\/j.1532-5415.2009.02494.x","article-title":"Human immunodeficiency virus in an aging population, a complication of success","volume":"57","author":"Kirk","year":"2009","journal-title":"J Am Geriatr Soc."},{"key":"2022021713154853100_CIT0002","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2147\/CIA.S14726","article-title":"Successful aging and the epidemiology of HIV","volume":"6","author":"Vance","year":"2011","journal-title":"Clin Interv Aging."},{"issue":"3","key":"2022021713154853100_CIT0003","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3233\/JAD-141086","article-title":"2003-2013: a decade of body mass index, Alzheimer\u2019s disease, and dementia","volume":"43","author":"Emmerzaal","year":"2015","journal-title":"J Alzheimers Dis."},{"issue":"1","key":"2022021713154853100_CIT0004","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2008.01.052","article-title":"A life course of adiposity and dementia","volume":"585","author":"Gustafson","year":"2008","journal-title":"Eur J Pharmacol."},{"issue":"6704","key":"2022021713154853100_CIT0005","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"Friedman","year":"1998","journal-title":"Nature."},{"issue":"2","key":"2022021713154853100_CIT0006","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/j.1550-8528.1999.tb00696.x","article-title":"Birth weight, adulthood BMI, and subsequent weight gain in relation to leptin levels in Swedish women","volume":"7","author":"Lissner","year":"1999","journal-title":"Obes Res."},{"issue":"6","key":"2022021713154853100_CIT0007","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/alzrt221","article-title":"High adiposity: risk factor for dementia and Alzheimer\u2019s disease?","volume":"5","author":"Gustafson","year":"2013","journal-title":"Alzheimers Res Ther."},{"issue":"3","key":"2022021713154853100_CIT0008","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3233\/JAD-180533","article-title":"Association between peripheral leptin and adiponectin levels and cognitive decline in patients with neurocognitive disorders \u2265\u200565 years","volume":"66","author":"Gilbert","year":"2018","journal-title":"J Alzheimers Dis."},{"issue":"23","key":"2022021713154853100_CIT0009","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1001\/jama.2009.1836","article-title":"Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging","volume":"302","author":"Lieb","year":"2009","journal-title":"JAMA."},{"issue":"2","key":"2022021713154853100_CIT0010","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/gerona\/gls155","article-title":"Leptin, mild cognitive impairment, and dementia among elderly women","volume":"68","author":"Zeki Al Hazzouri","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"2","key":"2022021713154853100_CIT0011","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pathophys.2009.04.004","article-title":"Prandial increase of leptin in the brain activates spatial learning and memory","volume":"17","author":"Oomura","year":"2010","journal-title":"Pathophysiology."},{"issue":"Pt 5","key":"2022021713154853100_CIT0012","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1042\/BST0331029","article-title":"Leptin: a potential cognitive enhancer?","volume":"33","author":"Harvey","year":"2005","journal-title":"Biochem Soc Trans."},{"issue":"5","key":"2022021713154853100_CIT0013","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.physbeh.2005.09.004","article-title":"Memory inhibition and energy regulation","volume":"86","author":"Davidson","year":"2005","journal-title":"Physiol Behav."},{"issue":"15","key":"2022021713154853100_CIT0014","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1096\/fj.04-2572com","article-title":"Obesity-related leptin regulates Alzheimer\u2019s Abeta","volume":"18","author":"Fewlass","year":"2004","journal-title":"FASEB J."},{"issue":"3","key":"2022021713154853100_CIT0015","doi-asserted-by":"crossref","first-page":"991S","DOI":"10.3945\/ajcn.2008.26788E","article-title":"Leptin in humans: lessons from translational research","volume":"89","author":"Bl\u00fcher","year":"2009","journal-title":"Am J Clin Nutr."},{"issue":"1-3","key":"2022021713154853100_CIT0016","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.regpep.2007.10.006","article-title":"Brain circuits regulating energy homeostasis","volume":"149","author":"Abizaid","year":"2008","journal-title":"Regul Pept."},{"issue":"8","key":"2022021713154853100_CIT0017","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/QAD.0b013e3280adc91e","article-title":"The role of adipokines in relation to HIV lipodystrophy","volume":"21","author":"Sweeney","year":"2007","journal-title":"AIDS."},{"issue":"9","key":"2022021713154853100_CIT0018","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S1474-4422(14)70085-7","article-title":"Adipokines: a link between obesity and dementia?","volume":"13","author":"Kiliaan","year":"2014","journal-title":"Lancet Neurol."},{"issue":"9","key":"2022021713154853100_CIT0019","first-page":"1013","article-title":"The Women\u2019s Interagency HIV Study: an observational cohort brings clinical sciences to the bench","volume":"12","author":"Bacon","year":"2005","journal-title":"Clin Diagn Lab Immunol."},{"issue":"2","key":"2022021713154853100_CIT0020","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00001648-199803000-00004","article-title":"The Women\u2019s Interagency HIV Study. WIHS Collaborative Study Group","volume":"9","author":"Barkan","year":"1998","journal-title":"Epidemiology."},{"issue":"3","key":"2022021713154853100_CIT0021","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/QAI.0b013e318162f597","article-title":"Longitudinal anthropometric patterns among HIV-infected and HIV-uninfected women","volume":"47","author":"Justman","year":"2008","journal-title":"J Acquir Immune Defic Syndr."},{"issue":"10","key":"2022021713154853100_CIT0022","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1089\/aid.2009.0038","article-title":"Elevated NT-pro-BNP levels are associated with comorbidities among HIV-infected women","volume":"25","author":"Mansoor","year":"2009","journal-title":"AIDS Res Hum Retroviruses."},{"volume-title":"Diet and Health: Implications for Reducing Chronic Disease Risk.","year":"1989","author":"National Research Council (US) Committee on Diet and Health.","key":"2022021713154853100_CIT0023"},{"issue":"18","key":"2022021713154853100_CIT0024","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1097\/QAD.0000000000002017","article-title":"Predicting diabetes risk among HIV-positive and HIV-negative women","volume":"32","author":"Galaviz","year":"2018","journal-title":"AIDS."},{"issue":"2","key":"2022021713154853100_CIT0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3109\/13697137.2011.650656","article-title":"Executive summary of STRAW\u2005+\u200510: addressing the unfinished agenda of staging reproductive aging","volume":"15","author":"Harlow","year":"2012","journal-title":"Climacteric."},{"issue":"1","key":"2022021713154853100_CIT0026","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/jcla.21718","article-title":"Serum leptin is associated with metabolic syndrome in obese Mexican subjects","volume":"29","author":"Garc\u00eda-Jim\u00e9nez","year":"2015","journal-title":"J Clin Lab Anal."},{"issue":"12","key":"2022021713154853100_CIT0027","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1373\/clinchem.2007.090670","article-title":"Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA","volume":"53","author":"Sinha","year":"2007","journal-title":"Clin Chem."},{"issue":"13","key":"2022021713154853100_CIT0028","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1097\/QAD.0b013e328300581d","article-title":"Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men","volume":"22","author":"Kaplan","year":"2008","journal-title":"AIDS."},{"issue":"4","key":"2022021713154853100_CIT0029","first-page":"137","article-title":"Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder","volume":"19","author":"Letendre","year":"2011","journal-title":"Top Antivir Med."},{"issue":"2","key":"2022021713154853100_CIT0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1212\/WNL.0000000000000564","article-title":"Antiretroviral penetration into the CNS and incidence of AIDS-defining neurologic conditions","volume":"83","author":"Caniglia","year":"2014","journal-title":"Neurology."},{"issue":"15","key":"2022021713154853100_CIT0031","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1212\/WNL.0000000000004491","article-title":"Cognitive trajectories over 4 years among HIV-infected women with optimal viral suppression","volume":"89","author":"Rubin","year":"2017","journal-title":"Neurology."},{"issue":"3","key":"2022021713154853100_CIT0032","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1212\/WNL.0000000000001151","article-title":"Cognitive function in women with HIV: findings from the Women\u2019s Interagency HIV Study","volume":"84","author":"Maki","year":"2015","journal-title":"Neurology."},{"issue":"1","key":"2022021713154853100_CIT0033","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/QAI.0000000000001755","article-title":"Cognitive burden of common non-antiretroviral medications in HIV-infected women","volume":"79","author":"Rubin","year":"2018","journal-title":"J Acquir Immune Defic Syndr."},{"issue":"4","key":"2022021713154853100_CIT0034","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1212\/WNL.0000000000002277","article-title":"Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study","volume":"86","author":"Sacktor","year":"2016","journal-title":"Neurology."},{"key":"2022021713154853100_CIT0035","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4172\/2167-7182.1000240","article-title":"Leptin, adiponectin and cognition in middle-aged HIV-infected and uninfected women. The Brooklyn Women\u2019s Interagency HIV Study","volume":"4","author":"Gustafson","year":"2015","journal-title":"J Gerontol Geriatr Res."},{"key":"2022021713154853100_CIT0036","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.psych.57.102904.190024","article-title":"Neuropsychological assessment of dementia","volume":"60","author":"Salmon","year":"2009","journal-title":"Annu Rev Psychol."},{"issue":"4","key":"2022021713154853100_CIT0037","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jalz.2011.05.2411","article-title":"Leptin and dementia over 32 years\u2014the Prospective Population Study of Women","volume":"8","author":"Gustafson","year":"2012","journal-title":"Alzheimers Dement."},{"issue":"6","key":"2022021713154853100_CIT0038","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s13365-013-0219-1","article-title":"Anthropometric measures and cognition in middle-aged HIV-infected and uninfected women. The Women\u2019s Interagency HIV Study","volume":"19","author":"Gustafson","year":"2013","journal-title":"J Neurovirol."},{"issue":"7","key":"2022021713154853100_CIT0039","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1212\/WNL.0b013e3182478d64","article-title":"Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder","volume":"78","author":"McCutchan","year":"2012","journal-title":"Neurology."},{"issue":"2","key":"2022021713154853100_CIT0040","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3851\/IMP2952","article-title":"Adiponectin and interleukin-6, but not adipose tissue, are associated with worse neurocognitive function in HIV-infected men","volume":"20","author":"Lake","year":"2015","journal-title":"Antivir Ther."},{"issue":"3","key":"2022021713154853100_CIT0041","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1093\/ajcn\/80.3.576","article-title":"Serum leptin concentrations and body adipose measures in older black and white adults","volume":"80","author":"Ruhl","year":"2004","journal-title":"Am J Clin Nutr."},{"issue":"3","key":"2022021713154853100_CIT0042","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3233\/JAD-190569","article-title":"Association between insulin resistance, plasma leptin, and neurocognition in vascular cognitive impairment","volume":"71","author":"Smith","year":"2019","journal-title":"J Alzheimers Dis."},{"issue":"3","key":"2022021713154853100_CIT0043","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1210\/jc.2015-2315","article-title":"Cognitive effects of intentional weight loss in elderly obese individuals with mild cognitive impairment","volume":"101","author":"Horie","year":"2016","journal-title":"J Clin Endocrinol Metab."},{"issue":"5223","key":"2022021713154853100_CIT0044","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene","volume":"269","author":"Halaas","year":"1995","journal-title":"Science."},{"issue":"8","key":"2022021713154853100_CIT0045","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1474-4422(06)70526-9","article-title":"Adiposity indices and dementia","volume":"5","author":"Gustafson","year":"2006","journal-title":"Lancet Neurol."},{"issue":"9","key":"2022021713154853100_CIT0046","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.neurobiolaging.2007.11.024","article-title":"Serum leptin level and cognition in the elderly: findings from the Health ABC Study","volume":"30","author":"Holden","year":"2009","journal-title":"Neurobiol Aging."},{"issue":"3","key":"2022021713154853100_CIT0047","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3233\/JAD-191247","article-title":"Association between leptin, cognition, and structural brain measures among \u201cearly\u201d middle-aged adults: results from the Framingham Heart Study Third Generation Cohort","volume":"77","author":"Sanborn","year":"2020","journal-title":"J Alzheimers Dis."},{"key":"2022021713154853100_CIT0048","doi-asserted-by":"crossref","first-page":"104783","DOI":"10.1016\/j.psyneuen.2020.104783","article-title":"Plasma leptin, but not adiponectin, is associated with cognitive impairment in older adults","volume":"120","author":"Feinkohl","year":"2020","journal-title":"Psychoneuroendocrinology."},{"issue":"9","key":"2022021713154853100_CIT0049","doi-asserted-by":"crossref","first-page":"e864","DOI":"10.1212\/WNL.0000000000008002","article-title":"Adiposity is related to cerebrovascular and brain volumetry outcomes in the RUN DMC study","volume":"93","author":"Arnoldussen","year":"2019","journal-title":"Neurology."},{"issue":"3","key":"2022021713154853100_CIT0050","doi-asserted-by":"crossref","first-page":"200","DOI":"10.2174\/157488909789104848","article-title":"Therapeutic approaches of leptin in Alzheimer\u2019s disease","volume":"4","author":"Carro","year":"2009","journal-title":"Recent Pat CNS Drug Discov."},{"key":"2022021713154853100_CIT0051","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fnagi.2019.00202","article-title":"A metabolic obesity profile is associated with decreased gray matter volume in cognitively healthy older adults","volume":"11","author":"Beyer","year":"2019","journal-title":"Front Aging Neurosci."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab759\/40820482\/dgab759.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/3\/e1126\/42545004\/dgab759.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/3\/e1126\/42545004\/dgab759.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T13:20:23Z","timestamp":1645104023000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/3\/e1126\/6408424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":51,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,10,22]]},"published-print":{"date-parts":[[2022,2,17]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab759","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"type":"print","value":"0021-972X"},{"type":"electronic","value":"1945-7197"}],"subject":[],"published-other":{"date-parts":[[2022,3,1]]},"published":{"date-parts":[[2021,10,22]]}}}