{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:40:41Z","timestamp":1775148041538,"version":"3.50.1"},"reference-count":45,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T00:00:00Z","timestamp":1635897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Egg consumption is one of the main dietary sources of cholesterol, but whether individuals who eat more eggs have a worse blood lipid profile remains controversial.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We examined the relationship between egg consumption and lipid parameters and explored whether this relationship changes according to the presence of chronic metabolic disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A multicenter cross-sectional study was conducted with adult participants in the EVIDENT II trial. Adjusted linear regression models were stratified by the main chronic metabolic disorders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 728 participants (61.9% women, mean age 52.1 \u00b1 11.9 years), the mean egg consumption was equivalent to 5 to 6 eggs per week for a 70-kg individual. In the fully adjusted analysis, no association was found of egg consumption with total and high-density lipoprotein cholesterol (HDL-c), and triglyceride levels. Furthermore, compared with the first quartile of consumption, the fourth quartile was associated with lower low-density lipoprotein cholesterol (LDL-c) levels (coefficient \u20137.01; 95% CI \u201313.39, \u20130.62) and a lower LDL-c\/HDL-c ratio (coefficient \u20130.24, 95% CI \u20130.41, \u20130.06). In the analyses stratified by chronic metabolic diseases, higher egg consumption was not associated with lipid profile in those with obesity, hypertension, type 2 diabetes, dyslipidemia, or treated with hypolipidemic drugs, and was associated with a better lipid profile in participants without these conditions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher egg consumption was not associated with blood lipids in individuals with chronic metabolic disorders. In individuals without such conditions, the lipid profile was better among those who consumed more eggs. Our findings support current guidelines recommending eggs as part of a healthy diet.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab802","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T02:44:21Z","timestamp":1635993861000},"page":"e963-e972","source":"Crossref","is-referenced-by-count":7,"title":["Egg Consumption and Blood Lipid Parameters According to the Presence of Chronic Metabolic Disorders: The EVIDENT II Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-8607","authenticated-orcid":false,"given":"Arthur Eumann","family":"Mesas","sequence":"first","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, 16071, Spain"},{"name":"Universidade Estadual de Londrina, Londrina, Paran\u00e1, 86057-970, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-616X","authenticated-orcid":false,"given":"Miriam","family":"Garrido-Miguel","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, 16071, Spain"},{"name":"Universidad de Castilla-La Mancha, Faculty of Nursing, Albacete, 02006, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9127-1735","authenticated-orcid":false,"given":"Rub\u00e9n","family":"Fern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, 16071, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Fern\u00e1ndez Franco","sequence":"additional","affiliation":[{"name":"Grupo Av\u00edcola Rujamar, San Lorenzo de la Parrilla, Cuenca, 16770, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6571-9556","authenticated-orcid":false,"given":"Cristina","family":"Lugones-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL), Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Gerencia de Atenci\u00f3n Primaria de Salamanca, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACyL), Salamanca, 37005, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-8302","authenticated-orcid":false,"given":"Luis","family":"Garc\u00eda-Ortiz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Atenci\u00f3n Primaria de Salamanca (APISAL), Instituto de investigaci\u00f3n Biom\u00e9dica de Salamanca (IBSAL), Gerencia de Atenci\u00f3n Primaria de Salamanca, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACyL), Salamanca, 37005, Spain"},{"name":"Universidad de Salamanca, Departamento de Ciencias Biom\u00e9dicas y del Diagn\u00f3stico, Salamanca, 37007, Spain"},{"name":"Investigadores grupo EVIDENT, redIAPP: Red Espa\u00f1ola de Investigaci\u00f3n para Actividades Preventivas y Promoci\u00f3n de la Salud en Atenci\u00f3n Primaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6121-7893","authenticated-orcid":false,"given":"Vicente","family":"Mart\u00ednez-Vizca\u00edno","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, 16071, Spain"},{"name":"Investigadores grupo EVIDENT, redIAPP: Red Espa\u00f1ola de Investigaci\u00f3n para Actividades Preventivas y Promoci\u00f3n de la Salud en Atenci\u00f3n Primaria"},{"name":"Universidad Aut\u00f3noma de Chile, Facultad de Ciencias de la Salud, Talca, 1101, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2021,11,3]]},"reference":[{"issue":"3","key":"2022021713274096500_CIT0001","doi-asserted-by":"crossref","DOI":"10.3390\/nu11030684","article-title":"The golden egg: nutritional value, bioactivities, and emerging benefits for human health","volume":"11","author":"Rehault-Godbert","journal-title":"Nutrients."},{"key":"2022021713274096500_CIT0002","volume-title":"Social Services and Equality. 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