{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:35:36Z","timestamp":1791848136400,"version":"4.3.4"},"reference-count":49,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Swedish government and V\u00e4stra G\u00f6talandsregionen","award":["ALFGBG-717311"],"award-info":[{"award-number":["ALFGBG-717311"]}]},{"name":"Swedish government and V\u00e4stra G\u00f6talandsregionen","award":["ALFGBG-790271"],"award-info":[{"award-number":["ALFGBG-790271"]}]},{"name":"Swedish government and V\u00e4stra G\u00f6talandsregionen","award":["ALFGBG-442391"],"award-info":[{"award-number":["ALFGBG-442391"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Neuropsychiatric symptoms are common features of Graves disease (GD) in hyperthyroidism and after treatment. The mechanism behind these symptoms is unknown, but reduced hippocampal volumes have been observed in association with increased thyroid hormone levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed at investigating GD influence on regional medial temporal lobe (MTL) volumes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Sixty-two women with newly diagnosed GD underwent assessment including magnetic resonance (MR) imaging in hyperthyroidism and 48 of them were followed up after a mean of 16.4\u2005\u00b1\u20054.2 SD months of treatment. Matched thyroid-healthy controls were also assessed twice at a 15-month interval. MR images were automatically segmented using multiatlas propagation with enhanced registration. Regional medial temporal lobe (MTL) volumes for amygdalae and hippocampi were compared with clinical data and data from symptom questionnaires and neuropsychological tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients had smaller MTL regions than controls at inclusion. At follow-up, all 4 MTL regions had increased volumes and only the volume of the left amygdala remained reduced compared to controls. There were significant correlations between the level of thyrotropin receptor antibodies (TRAb) and MTL volumes at inclusion and also between the longitudinal difference in the levels of free 3,5,3\u2032-triiodothyronine and TRAb and the difference in MTL volumes. There were no significant correlations between symptoms or test scores and any of the 4 MTL volumes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Dynamic alterations in the amygdalae and hippocampi in GD reflect a previously unknown level of brain involvement both in the hyperthyroid state of the condition and after treatment. The clinical significance, as well as the mechanisms behind these novel findings, warrant further study of the neurological consequences of GD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab808","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T19:30:20Z","timestamp":1636486220000},"page":"1040-1052","source":"Crossref","is-referenced-by-count":18,"title":["A Longitudinal Study of Medial Temporal Lobe Volumes in Graves Disease"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2884-9981","authenticated-orcid":false,"given":"Mats","family":"Holmberg","sequence":"first","affiliation":[{"name":"ANOVA, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Malmgren","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"},{"name":"MedTech West at University of Gothenburg and Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf A","family":"Heckemann","sequence":"additional","affiliation":[{"name":"MedTech West at University of Gothenburg and Sahlgrenska University Hospital, G\u00f6teborg, Sweden"},{"name":"Institute of Clinical Sciences, Department of Medical Radiation Sciences, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Johansson","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Klasson","sequence":"additional","affiliation":[{"name":"MedTech West at University of Gothenburg and Sahlgrenska University Hospital, G\u00f6teborg, Sweden"},{"name":"Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Olsson","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Skau","sequence":"additional","affiliation":[{"name":"MedTech West at University of Gothenburg and Sahlgrenska University Hospital, G\u00f6teborg, Sweden"},{"name":"Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Starck","sequence":"additional","affiliation":[{"name":"Institute of Clinical Sciences, Department of Medical Radiation Sciences, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"},{"name":"Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Filipsson Nystr\u00f6m","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, G\u00f6teborg, Sweden"},{"name":"Department of Endocrinology, Sahlgrenska University Hospital, G\u00f6teborg, Sweden"},{"name":"Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, G\u00f6teborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"issue":"3","key":"2022032516101973100_CIT0001","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/thy.2013.0058","article-title":"Hippocampal volume is decreased in adults with hypothyroidism","volume":"24","author":"Cooke","year":"2014","journal-title":"Thyroid."},{"issue":"5","key":"2022032516101973100_CIT0002","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/eje.0.1510549","article-title":"Impaired health-related quality of life in Graves\u2019 disease. 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