{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:59:08Z","timestamp":1792522748096,"version":"4.5.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR001873"],"award-info":[{"award-number":["UL1TR001873"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism (PHPT) is associated with subclinical cardiovascular disease, but data regarding cardiac conduction abnormalities are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective and Design<\/jats:title>\n                  <jats:p>Retrospective cross-sectional comparison of cardiac conduction in patients with PHPT or thyroid disease (TD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants and Setting<\/jats:title>\n                  <jats:p>Patients \u226540 years old who underwent parathyroidectomy or thyroidectomy at a single tertiary institution from 2013 to 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Outcomes<\/jats:title>\n                  <jats:p>Demographics and preoperative electrocardiogram (EKG) parameters were compared using the Mann-Whitney U, chi-square test, and linear regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1242 patients were included: 49.8% PHPT (n = 619) and 50.2% TD (n = 623). Median age was 60.5 years [interquartile range (IQR) 53.6-67.9]. Compared to controls, PHPT patients had higher median serum calcium [10.7 mg\/dL (IQR 10.4-11.1) vs 9.5 mg\/dL (IQR 9.3-9.8), P &amp;lt; 0.001] as expected, as well as, a higher prevalence of hyperlipidemia (49% vs 36%, P &amp;lt; 0.001) and hypertension (50.1% vs 42.2%, P &amp;lt; 0.01). Based on EKG, there was no difference in PR interval or the prevalence of arrhythmia, atrioventricular block, ST segment\/T wave changes, premature ventricular complexes, right bundle branch block, or left bundle branch block after adjusting for covariates. The PHPT group had a lower mean corrected QT interval (414 \u00b1 24) ms vs 422 \u00b1 24 ms, P &amp;lt; 0.01), adjusted for covariates. Serum calcium predicted QTc independently of age, sex, and other covariates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In the largest study to date, PHPT patients had shorter QTc intervals compared to TD controls but no increased prevalence of arrhythmia based on preoperative EKG.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab820","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T19:30:38Z","timestamp":1636486238000},"page":"e1689-e1698","source":"Crossref","is-referenced-by-count":7,"title":["Primary Hyperparathyroidism Is Associated With Shorter QTc Intervals, but Not Arrhythmia"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7898-2719","authenticated-orcid":false,"given":"Latoya A","family":"Stewart","sequence":"first","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle K","family":"Steinl","sequence":"additional","affiliation":[{"name":"Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernice L","family":"Huang","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"McManus","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Lee","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer H","family":"Kuo","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7205-6527","authenticated-orcid":false,"given":"Marcella D","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"issue":"4","key":"2022032516101985600_CIT0001","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2362.1998.00289.x","article-title":"Increased risk of death from primary hyperparathyroidism\u2014an update","volume":"28","author":"Hedb\u00e4ck","year":"1998","journal-title":"Eur J Clin Invest."},{"issue":"1","key":"2022032516101985600_CIT0002","first-page":"1","article-title":"Mortality after surgery for primary hyperparathyroidism: a follow-up of 441 patients operated on from 1956 to 1979","volume":"102","author":"Palm\u00e9r","year":"1987","journal-title":"Surgery."},{"issue":"2","key":"2022032516101985600_CIT0003","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9343(97)00270-2","article-title":"Survival after the diagnosis of hyperparathyroidism: a population-based study","volume":"104","author":"Wermers","year":"1998","journal-title":"Am J Med."},{"issue":"10","key":"2022032516101985600_CIT0004","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/jc.2014-1415","article-title":"Current issues in the presentation of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop","volume":"99","author":"Silverberg","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2022032516101985600_CIT0005","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/BF03346443","article-title":"Cardiovascular aspects of primary hyperparathyroidism","volume":"31","author":"Walker","year":"2008","journal-title":"J Endocrinol Invest."},{"issue":"6","key":"2022032516101985600_CIT0006","doi-asserted-by":"crossref","first-page":"R297","DOI":"10.1530\/EJE-17-0485","article-title":"Cardiovascular manifestations of primary hyperparathyroidism: a narrative review","volume":"177","author":"Pepe","year":"2017","journal-title":"Eur J Endocrinol."},{"issue":"11","key":"2022032516101985600_CIT0007","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.jacc.2008.12.014","article-title":"AHA\/ACCF\/HRS recommendations for the standardization and interpretation of the electrocardiogram: Part IV: the ST segment, T and U waves, and the QT interval: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; 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