{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:56:17Z","timestamp":1781657777424,"version":"3.54.5"},"reference-count":38,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The increase in the incidence of congenital hypothyroidism (CH) reported worldwide may partly be explained by an increase in the transient form of CH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to estimate the proportion of transient CH (TCH) in France, and to identify associated neonatal and young child characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used probabilistic record linkage to link children with eutopic gland born between 2006 and 2012 recorded in the national French CH registry and the French national health data system (SNDS). Of the 703 children recorded, 484 (68.8%) were linked. We retrospectively examined reimbursement for oral levothyroxine (LT4) between January 1, 2006, and December 31, 2017. Children who had discontinued treatment for 6 months or more before December 31, 2017, were classified as having TCH. We used a Cox model to examine the factors associated with TCH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the main study sample (n\u2005=\u2005471), 53.5% were female, 14.2% were preterm, and 13.8% had low birth weight. One-quarter (n\u2005=\u2005111, 24.3%) had mild CH (thyroid-stimulating hormone [TSH]\u2005&amp;lt;\u200550 mU\/L, serum) at diagnosis and a median LT4 dose at treatment initiation of 30 \u03bcg\/day. One-third (n\u2005=\u2005155, 32.9%) had TCH. Premature birth (adjusted hazard ratio\u2005=\u20052.1 [1.0\u20134.2]), a TSH\u2005&amp;lt;\u200550 mU\/L at CH screening (7.4 [3.2\u201317.1]), LT4 dose received at 12 months of age (0.98 [0.97\u20130.99, P\u2005=\u20050.003]), congenital cardiac malformations (6.6 [1.5\u201329.0]), and year of birth (1.2 [1.1\u20131.4]) were all associated with TCH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>One-third of the children had TCH, and it was associated with several characteristics at birth and postpartum. These data are useful for CH medical management and epidemiological surveillance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab854","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T07:49:52Z","timestamp":1638344992000},"page":"e1501-e1509","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence and Determinants of Transient Congenital Hypothyroidism in Children With Eutopic Gland in France: A Retrospective Cohort Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6963-2618","authenticated-orcid":false,"given":"Yaya","family":"Barry","sequence":"first","affiliation":[{"name":"Sant\u00e9 Publique France, the French National Public Health Agency, Non-Communicable Diseases and Trauma Division, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Mandereau-Bruno","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France, the French National Public Health Agency, Data Science Division, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bonaldi","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France, the French National Public Health Agency, Data Science Division, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cheillan","sequence":"additional","affiliation":[{"name":"Univ Lyon, CarMeN laboratory, INSERM- U1060, INRAE, INSA Lyon, Universit\u00e9 Claude Bernard Lyon 1, Charles M\u00e9rieux Medical School, Pierre-B\u00e9nite, France"},{"name":"Hospices Civils de Lyon, Lyon, France"},{"name":"Unit\u00e9 Maladies H\u00e9r\u00e9ditaires du M\u00e9tabolisme, Service de Biochimie et Biologie Mol\u00e9culaire Grand Est, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Coutant","sequence":"additional","affiliation":[{"name":"CHU-Angers, Unit\u00e9 Endocrinologie Diab\u00e9tologie P\u00e9diatrique and Centre des Maladies Rares de la R\u00e9ceptivit\u00e9 Hormonale, Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"L\u00e9ger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Diabetology, Reference Centre for Endocrine Growth and Development Diseases, Assistance Publique\u2014H\u00f4pitaux de Paris, Robert Debr\u00e9 University Hospital, Paris, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), UMR, DHU Protect, Paris, France"},{"name":"Paris Diderot University, Sorbonne Paris Cite\u00b4, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-1450","authenticated-orcid":false,"given":"Nolwenn","family":"Regnault","sequence":"additional","affiliation":[{"name":"Sant\u00e9 Publique France, the French National Public Health Agency, Non-Communicable Diseases and Trauma Division, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"issue":"9","key":"2022032516104094000_CIT0001","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1210\/jc.2012-1562","article-title":"Etiology of increasing incidence of congenital hypothyroidism in New Zealand from 1993-2010","volume":"97","author":"Albert","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"2022032516104094000_CIT0002","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1210\/jc.2011-1073","article-title":"Is the incidence of congenital hypothyroidism really increasing? 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