{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:21:08Z","timestamp":1781857268273,"version":"3.54.5"},"reference-count":30,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T00:00:00Z","timestamp":1638057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Although blood pressure variability (BPV) is associated with various health outcomes, only 1 study suggested that BPV is correlated with hip fractures. As cardiovascular disease and fractures share similar pathophysiology, there might be a link between BPV and fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the association between BPV and the incident fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Population-based, using the Korean National Health Insurance System database.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients or Other Participants<\/jats:title>\n                  <jats:p>A total of 3 256 070 participants aged \u226550 who participated in \u22653 health examinations within the previous 5 years, including the index year (2009-2010), were included. Outcome data were obtained through the end of 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Exposure<\/jats:title>\n                  <jats:p>BPV was calculated using variability independent of the mean. High variability was defined as the highest quartile of variability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Newly diagnosed fractures.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the median follow-up of 7.0 years, there were 337 045 cases of any fracture (10.4%). After adjusting for age, sex, income, lifestyle factors, and comorbidities, a higher risk of fracture was observed with higher quartiles of BPV than the lowest quartile group: the adjusted hazard ratios (95% CIs) for incident any fracture were 1.07 (1.06-1.08) in the higher quartile of systolic BPV, 1.06 (1.05-1.07) in that of diastolic BPV, and 1.07 (1.06-1.08) in that of both systolic and diastolic BPV. Consistent results were noted for vertebral fractures and hip fractures, as well as in various subgroup analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A positive association was noted between higher BPV and fracture incidence. BPV is an independent predictor for developing fracture.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgab856","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T08:50:40Z","timestamp":1638348640000},"page":"e1488-e1500","source":"Crossref","is-referenced-by-count":18,"title":["Blood Pressure Variability and the Risk of Fracture: A Nationwide Cohort Study"],"prefix":"10.1210","volume":"107","author":[{"given":"Jung Eun","family":"Yoo","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Won","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6096-1263","authenticated-orcid":false,"given":"Kyungdo","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea"},{"name":"Department of Medical Statistics, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8128-8920","authenticated-orcid":false,"given":"Dong Wook","family":"Shin","sequence":"additional","affiliation":[{"name":"Supportive Care Center\/ Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea"},{"name":"Department of Clinical Research Design & Evaluation, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2021,11,28]]},"reference":[{"key":"2022032516104115900_CIT0001","volume-title":"Facts & statistics:","author":"epidemiology of osteoporosis and fractures."},{"issue":"2","key":"2022032516104115900_CIT0002","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00223-008-9198-2","article-title":"Hypertension is a risk factor for fractures","volume":"84","author":"Vestergaard","year":"2009","journal-title":"Calcif Tissue Int."},{"issue":"1","key":"2022032516104115900_CIT0003","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s00223-002-2070-x","article-title":"Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women","volume":"73","author":"Tank\u00f2","year":"2003","journal-title":"Calcif Tissue Int."},{"issue":"9183","key":"2022032516104115900_CIT0004","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(99)01437-3","article-title":"High blood pressure and bone-mineral loss in elderly white women: a prospective study. 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