{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:45:09Z","timestamp":1792788309270,"version":"4.5.0"},"reference-count":39,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Novo-Nordisk France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Endocrine complications are common in pediatric brain tumor patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to describe the endocrine follow-up of patients with primary brain tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a noninterventional observational study based on data collection from medical records of 221 patients followed at a Pediatric Endocrinology Department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median age at diagnosis was 6.7 years (range, 0-15.9), median follow-up 6.7 years (0.3-26.6), 48.9% female. Main tumor types were medulloblastoma (37.6%), craniopharyngioma (29.0%), and glioma (20.4%). By anatomic location, 48% were suprasellar (SS) and 52% non-suprasellar (NSS). Growth hormone deficiency (GHD) prevalence was similar in both groups (SS: 83.0%, NSS: 76.5%; P = 0.338), appearing at median 1.8 years (\u22120.8 to 12.4) after diagnosis; postradiotherapy GHD appeared median 1.6 years after radiotherapy (0.2-10.7). Hypothyroidism was more prevalent in SS (76.4%), than NSS (33.9%) (P &amp;lt; 0.001), as well as ACTH deficiency (SS: 69.8%, NSS: 6.1%; P &amp;lt; 0.001). Early puberty was similar in SS (16%) and NSS (12.2%). Hypogonadotropic hypogonadism was predominant in SS (63.1%) vs NSS (1.3%), P &amp;lt; 0.001, and postchemotherapy gonadal toxicity in NSS (29.6%) vs SS (2.8%), P &amp;lt; 0.001. Adult height was lower for NSS compared to target height (\u22121.0 SD, P &amp;lt; 0.0001) and to SS patients (P &amp;lt; 0.0001). Thyroid nodules were found in 13\/45 patients (28.8%), including 4 cancers (4.8-11.5 years after radiotherapy). Last follow-up visit BMI was higher in both groups (P = 0.0001), and obesity incidence was higher for SS (46.2%) than NSS (17.4%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found a high incidence of early-onset endocrine disorders. An endocrine consultation and nutritional evaluation should be mandatory for all patients with a brain tumor, especially when the tumor is suprasellar or after hypothalamus\/pituitary irradiation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgab893","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T20:27:35Z","timestamp":1639686455000},"page":"e2156-e2166","source":"Crossref","is-referenced-by-count":27,"title":["High Prevalence of Early Endocrine Disorders After Childhood Brain Tumors in a Large Cohort"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0323-5270","authenticated-orcid":false,"given":"Laura Gabriela","family":"Gonz\u00e1lez Brice\u00f1o","sequence":"first","affiliation":[{"name":"H\u00f4pital Universitaire Necker-Enfants Malades - Assistance Publique H\u00f4pitaux de Paris (APHP), Service d\u2019Endocrinologie, gyn\u00e9cologie et diab\u00e9tologie p\u00e9diatrique, Institut IMAGINE (affiliate), 75015 Paris, France"},{"name":"ESPE Fellowship \u2013 European Society for Paediatric Endocrinology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3870-202X","authenticated-orcid":false,"given":"Dulanjalee","family":"Kariyawasam","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire Necker-Enfants Malades - Assistance Publique H\u00f4pitaux de Paris (APHP), Service d\u2019Endocrinologie, gyn\u00e9cologie et diab\u00e9tologie p\u00e9diatrique, Institut IMAGINE (affiliate), 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1135-933X","authenticated-orcid":false,"given":"Dinane","family":"Samara-Boustani","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire Necker-Enfants Malades - Assistance Publique H\u00f4pitaux de Paris (APHP), Service d\u2019Endocrinologie, gyn\u00e9cologie et diab\u00e9tologie p\u00e9diatrique, Institut IMAGINE (affiliate), 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7806-9241","authenticated-orcid":false,"given":"Elisa","family":"Giani","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire Necker-Enfants Malades - Assistance Publique H\u00f4pitaux de Paris (APHP), Service d\u2019Endocrinologie, gyn\u00e9cologie et diab\u00e9tologie p\u00e9diatrique, Institut IMAGINE (affiliate), 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3759-3490","authenticated-orcid":false,"given":"Jacques","family":"Beltrand","sequence":"additional","affiliation":[{"name":"H\u00f4pital Universitaire Necker-Enfants Malades - Assistance Publique H\u00f4pitaux de Paris (APHP), Service d\u2019Endocrinologie, gyn\u00e9cologie et diab\u00e9tologie p\u00e9diatrique, Institut IMAGINE (affiliate), 75015 Paris, France"},{"name":"Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Bolle","sequence":"additional","affiliation":[{"name":"Institut Gustave Roussy, D\u00e9partement de radioth\u00e9rapie-oncologie, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-7828","authenticated-orcid":false,"given":"Brice","family":"Fresneau","sequence":"additional","affiliation":[{"name":"Gustave Roussy, Universit\u00e9 Paris-Saclay, Department of Pediatric and Adolescent Oncology, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Puget","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, 75006 Paris, France"},{"name":"H\u00f4pital Universitaire Necker-Enfants Malades - APHP, Service Neurochirurgie, 75015 Paris, 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