{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:16:18Z","timestamp":1788369378739,"version":"build-2803163510"},"reference-count":40,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The role of vitamin D on muscle health is debated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An individual participant metanalysis of 4 randomized placebo-controlled trials, investigating short-term (3-9months) effects of vitamin D3 in moderate (2800 IU) to high (7000 IU) daily oral doses on muscle health and quality of life (QoL). Inclusion criteria were either obesity (n\u2005=\u200552), newly diagnosed primary hyperparathyroidism (n\u2005=\u200541), Graves\u2019 disease (n\u2005=\u200586), or secondary hyperparathyroidism (n\u2005=\u200581).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall (n\u2005=\u2005260) as well as in a subgroup analysis including only vitamin D insufficient [25(OH)D\u2005&amp;lt;\u200550 nmol\/L] individuals (n\u2005=\u2005176), vitamin D supplementation did not affect measures of muscle health (isometric muscle strength, Timed Up and Go test, chair rising test, body composition, and balance) or QoL. However, a beneficial effect was present on QoL (physical component score) in vitamin D deficient [25(OH)D\u2005&amp;lt;\u200525 nmol\/L] individuals (n\u2005=\u200534). Overall, relative changes in 25(OH)D inversely affected maximum muscle strength in a dose-response manner. Stratified into body mass index &amp;lt;\/&amp;gt; 30 kg\/m2, vitamin D supplementation had divergent effects on isometric muscle strength, with beneficial effects in obese individuals (n\u2005=\u200593) at knee flexion 90\u00b0 (P\u2005=\u20050.04), and adverse effects in nonobese individuals (n\u2005=\u2005167) at handgrip (P\u2005=\u20050.02), knee extension 60\u00b0 (P\u2005=\u20050.03) and knee flexion 60\u00b0 (P\u2005&amp;lt;\u20050.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, short-term treatment with moderate to high daily doses of vitamin D did not affect muscle health or QoL. A potential beneficial effect was present on muscle strength in severely obese individuals and on QoL in vitamin D deficient individuals. Subgroup analyses, however, suggested negative effects of large relative increases in p-25(OH)D.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgac004","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T04:28:29Z","timestamp":1641961709000},"page":"1317-1327","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Daily Vitamin D3 Supplementation on Muscle Health: An Individual Participant Meta-analysis"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-9518","authenticated-orcid":false,"given":"Lise Sofie","family":"Bislev","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Institute of Clinical Medicine, Aarhus University, Aarhus, 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