{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:19:34Z","timestamp":1770419974788,"version":"3.49.0"},"reference-count":76,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Fonds de recherche du Qu\u00e9bec-Sant\u00e9"},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Vertebral fracture (VF) prevalence up to 24% has been reported among young people with type 1 diabetes (T1D). If this high prevalence is confirmed, individuals with T1D could benefit from preventative VF screening.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We compared the prevalence of VFs between adults with T1D and nondiabetic controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study included 127 adults with T1D, and 65 controls with a similar age, sex, and BMI distribution, from outpatient clinics of 2 tertiary care centers. Vertebral fracture assessment (VFA) by dual-energy x-ray absorptiometry (DXA) was used for prevalent VFs. The modified algorithm-based qualitative (mABQ) method was applied. Bone mineral density (BMD) and trabecular bone score (TBS) were assessed by DXA. Serum bone turnover markers and sclerostin were measured in a subgroup of participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants with T1D (70 women, 57 men) had a mean age of 42.8\u2005\u00b1\u200514.8 years, median diabetes duration of 25.8 (15.8-34.4) years, mean BMI of 26.6\u2005\u00b1\u20055.4 kg\/m2 and mean HbA1c over the past 3 years of 7.5\u2005\u00b1\u20050.9%. Controls (35 women, 30 men) had mean age of 42.2\u2005\u00b1\u200515.9 years and mean BMI of 26.1\u2005\u00b1\u20055.1 kg\/m2. VF prevalence was comparable between groups (2.4% vs 3.1%, P\u2005=\u20050.99). TBS, BMD at the total hip and femoral neck, and bone formation and resorption markers were lower while sclerostin levels were similar in participants with T1D vs controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our VFA results using the mABQ method do not confirm increased prevalence of VFs in men and women with relatively well-controlled T1D.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac031","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T23:02:02Z","timestamp":1643410922000},"page":"e1860-e1870","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of Vertebral Fractures in Adults With Type 1 Diabetes: DenSiFy Study (Diabetes Spine Fractures)"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-618X","authenticated-orcid":false,"given":"Julie-Catherine","family":"Coll","sequence":"first","affiliation":[{"name":"Centre de recherche, CHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c9lodie","family":"Garceau","sequence":"additional","affiliation":[{"name":"Centre de recherche, CHU de Qu\u00e9bec-Universit\u00e9 Laval, Quebec City, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-1691","authenticated-orcid":false,"given":"William D","family":"Leslie","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Genest","sequence":"additional","affiliation":[{"name":"Centre de recherche, CHU de 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