{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:08:01Z","timestamp":1790611681709,"version":"4.1.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The number of reported cases with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccine\u2013induced subacute thyroiditis (SAT) and Graves\u2019 disease (GD) is growing. However, active debate continues about managing such side effects and the safety of repeat or booster doses of the vaccines in such cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aims to present long-term clinical follow-up of SARS-CoV-2 vaccine\u2013induced SAT or GD cases and provide data regarding the safety of revaccinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients diagnosed with SARS-CoV-2 vaccine\u2013induced SAT or GD were included. Data regarding the long-term clinical follow-up of SARS-CoV-2 vaccine\u2013induced SAT and GD cases and outcomes of repeat or booster SARS-CoV-2 vaccinations were documented. The literature, including cases of SARS-CoV-2 vaccine\u2013induced SAT or GD, was reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifteen patients with SARS-CoV-2 vaccine\u2013induced SAT and 4 with GD were included. Pfizer\/BioNTech COVID-19 vaccine (BNT162b2) was associated with symptoms in a majority of cases with SAT and all with GD. Median time from vaccination to symptom onset was 7 and 11.5 days, respectively, while 7 and 2 patients required medical treatment in SAT and GD groups, respectively. Remission was documented in 10 SAT patients, with a median time to remission of 11.5 weeks. No exacerbation\/recurrence of SAT occurred in 7 of 9 patients who received a repeat vaccination dose, while symptoms of SAT worsened following the second vaccination in 2 cases. None of the patients experienced severe side effects that could be associated with revaccinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Revaccinations appear to be safe in patients with SARS-CoV-2 vaccine\u2013induced SAT cases, while more evidence is needed regarding SARS-CoV-2 vaccine\u2013induced GD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac049","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:24:30Z","timestamp":1643675070000},"page":"e1823-e1834","source":"Crossref","is-referenced-by-count":37,"title":["SARS-CoV-2 Vaccine\u2013induced Thyroiditis: Safety of Revaccinations and Clinical Follow-up"],"prefix":"10.1210","volume":"107","author":[{"given":"Seda Hanife","family":"O\u011fuz","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, 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