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Patients included all youth with KS in the database (n\u2005=\u20051080) and 4497 youth without KS matched for sex, age (mean 13 years at last encounter), year of birth, race, ethnicity, insurance, site, and duration of care (mean 7 years). The main outcome measures were prevalence of 5 cardiometabolic-related outcomes: overweight\/obesity, dyslipidemia, dysglycemia, hypertension, and liver dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The odds of overweight\/obesity (OR 1.6; 95% CI 1.4-1.8), dyslipidemia (3.0; 2.2-3.9), and liver dysfunction (2.0; 1.6-2.5) were all higher in KS than in controls. Adjusting for covariates (obesity, testosterone treatment, and antipsychotic use) attenuated the effect of KS on these outcomes; however, boys with KS still had 45% greater odds of overweight\/obesity (95% CI 1.2-1.7) and 70% greater odds of liver dysfunction (95% CI 1.3-2.2) than controls, and both dyslipidemia (1.6; 1.1-2.4) and dysglycemia (1.8; 1.1-3.2) were higher in KS but of borderline statistical significance when accounting for multiple comparisons. The odds of hypertension were not different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This large, population-based cohort of youth with KS had a higher odds of most cardiometabolic-related diagnoses than matched controls.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgac056","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T01:12:27Z","timestamp":1643764347000},"page":"e1850-e1859","source":"Crossref","is-referenced-by-count":21,"title":["Population-based Assessment of Cardiometabolic-related Diagnoses in Youth With Klinefelter Syndrome: A PEDSnet Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-9550","authenticated-orcid":false,"given":"Shanlee M","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado School of Medicine , Aurora, CO 80045 , USA"},{"name":"eXtraOrdinarY Kids Clinic, Children\u2019s 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