{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:00:16Z","timestamp":1793246416866,"version":"4.5.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"International Research and Research Training Centre for Male Reproduction and Child Health","award":["1500321\/1604357"],"award-info":[{"award-number":["1500321\/1604357"]}]},{"name":"Candy Foundation","award":["2017-224"],"award-info":[{"award-number":["2017-224"]}]},{"name":"Candy Foundation","award":["2020-344"],"award-info":[{"award-number":["2020-344"]}]},{"name":"Absalon Foundation","award":["F-23653-01"],"award-info":[{"award-number":["F-23653-01"]}]},{"name":"European Union\u2019s Horizon 2020","award":["733032"],"award-info":[{"award-number":["733032"]}]},{"DOI":"10.13039\/501100007036","name":"Danish Environmental Protection Agency","doi-asserted-by":"crossref","award":["MST-621-00012"],"award-info":[{"award-number":["MST-621-00012"]}],"id":[{"id":"10.13039\/501100007036","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research council of Capital Region of Denmark","award":["E-22717-11"],"award-info":[{"award-number":["E-22717-11"]}]},{"name":"Research council of Rigshospitalet","award":["E-22717-12"],"award-info":[{"award-number":["E-22717-12"]}]},{"name":"Research council of Rigshospitalet","award":["E-22717-07"],"award-info":[{"award-number":["E-22717-07"]}]},{"name":"Research council of Rigshospitalet","award":["E-22717-08"],"award-info":[{"award-number":["E-22717-08"]}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","award":["10-001874"],"award-info":[{"award-number":["10-001874"]}],"id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The male hypothalamic-pituitary-gonadal (HPG) axis is transiently active during the first months of life with surging serum concentrations of reproductive hormones. This period, termed minipuberty, appears to be essential for priming testicular function. Despite the central role for male reproductive function, longitudinal data on HPG axis activation in infancy is sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the dynamics of HPG hormone activity in healthy male infants, to assess the association of HPG axis activity and testicular volume, and to establish reference curves for serum levels of reproductive hormones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, longitudinal birth cohort (the COPENHAGEN Minipuberty Study, 2016-2018, 1-year follow-up).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Population-based.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients or Other Participants<\/jats:title>\n                    <jats:p>Healthy, male, term, singleton newborns were followed from birth on with repeated clinical examinations including blood sampling during a 1-year follow-up. A total of 128 boys contributed to this study, while 119 participated in the postnatal follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Outcome Measures<\/jats:title>\n                    <jats:p>Serum reproductive hormone concentrations and testicular volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reproductive hormone concentrations showed marked dynamics during the first 6 months of age. Gonadotropins, total testosterone, and insulin-like factor 3 peaked at around 1 month of age. Inhibin B, anti-M\u00fcllerian hormone, and testicular volume peaked at around 4 to 5 months. Correlations largely recapitulated typical HPG axis pathways but also differed significantly from adult men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate a temporal dissociation of Leydig and Sertoli cell activity during male minipuberty and provide reference curves for reproductive hormones.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac115","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T06:32:22Z","timestamp":1646029942000},"page":"1560-1568","source":"Crossref","is-referenced-by-count":60,"title":["Dynamic Changes of Reproductive Hormones in Male Minipuberty: Temporal Dissociation of Leydig and Sertoli Cell Activity"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-569X","authenticated-orcid":false,"given":"Alexander Siegfried","family":"Busch","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen, Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7418-6878","authenticated-orcid":false,"given":"Marie Lindhardt","family":"Ljubicic","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen, Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-7590","authenticated-orcid":false,"given":"Emmie N","family":"Upners","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen, Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit Bistrup","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen, Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Lau","family":"Raket","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-9879","authenticated-orcid":false,"given":"Hanne","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet, Copenhagen, Denmark"},{"name":"International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2842-1128","authenticated-orcid":false,"given":"Jakob","family":"Albrethsen","sequence":"additional","affiliation":[{"name":"Department of Growth and 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