{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:19:00Z","timestamp":1783477140170,"version":"3.55.0"},"reference-count":90,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypopituitarism in childhood is a rare, complex disorder that can present with highly variable phenotypes, which may continue into adult life. Pituitary deficits can evolve over time, with unpredictable patterns resulting in significant morbidity and mortality. Hypopituitarism and hypothalamic dysfunction may be associated with challenging comorbidities such as obesity, learning difficulties, behavioral issues, sleep disturbance, and visual impairment. Transition is the purposeful planned movement of adolescents and young adults with chronic conditions from child-centered to adult-oriented health care systems with a shift from parent- to patient-focused care. To achieve effective transition within a health care setting, the inherent challenges involved in the evolution from a dependent child to an independent adult must be recognized. Transition is a critical time medically for patients with hypopituitarism. Complex issues with respect to puberty, attainment of optimal stature, adherence to treatment, and acceptance of the need for life-sustaining medications need to be addressed. For health care professionals, transition is an opportunity for reassessment of the pituitary deficits and the need for lifelong replacement therapies, often against a background of complex psychological issues. We present 4 illustrative cases of hypopituitarism of differing etiologies with diverse clinical presentations. Diagnostic and management processes from clinical presentation to young adulthood are discussed, with a particular focus on needs and outcomes through transition.<\/jats:p>","DOI":"10.1210\/clinem\/dgac129","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T15:44:13Z","timestamp":1646840653000},"page":"2077-2091","source":"Crossref","is-referenced-by-count":7,"title":["Approach to the Patient: Management of Pituitary Hormone Replacement Through Transition"],"prefix":"10.1210","volume":"107","author":[{"given":"Manuela","family":"Cerbone","sequence":"first","affiliation":[{"name":"London Centre for Paediatric Endocrinology and Diabetes at Great Ormond Street Children\u2019s Hospital and University College London Hospitals , London WC1N 1EH , UK"},{"name":"Section of Molecular Basis of Rare Disease, Genetics and Genomic Medicine Programme, University College London Great Ormond Street Institute of Child Health , London WC1N 1EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harshini","family":"Katugampola","sequence":"additional","affiliation":[{"name":"London Centre for Paediatric Endocrinology and Diabetes at Great Ormond Street Children\u2019s Hospital and University College London Hospitals , London WC1N 1EH , UK"},{"name":"Section of Molecular Basis of Rare Disease, Genetics and Genomic Medicine Programme, University College London Great Ormond Street Institute of Child Health , London WC1N 1EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen L","family":"Simpson","sequence":"additional","affiliation":[{"name":"Section of Molecular Basis of Rare Disease, Genetics and Genomic Medicine Programme, University College London Great Ormond Street Institute of Child Health , London WC1N 1EH , UK"},{"name":"Department of Diabetes and Endocrinology, University College London Hospitals NHS Trust , London NW1 2BU , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0365-5809","authenticated-orcid":false,"given":"Mehul T","family":"Dattani","sequence":"additional","affiliation":[{"name":"London Centre for Paediatric Endocrinology and Diabetes at Great Ormond Street Children\u2019s Hospital and University College London Hospitals , London WC1N 1EH , UK"},{"name":"Section of Molecular Basis of Rare Disease, Genetics and Genomic Medicine Programme, University College London Great Ormond Street Institute of Child Health , London WC1N 1EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"2022061616044618600_CIT0001","doi-asserted-by":"crossref","first-page":"100224","DOI":"10.1016\/j.eclinm.2019.11.017","article-title":"Endocrine morbidity in midline brain defects: Differences between septo-optic dysplasia and related disorders","volume":"19","author":"Cerbone","year":"2020","journal-title":"EClinicalMedicine."},{"issue":"9254","key":"2022061616044618600_CIT0002","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0140-6736(00)04006-X","article-title":"Association between premature mortality and hypopituitarism. 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