{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:09:07Z","timestamp":1791410947029,"version":"4.3.3"},"reference-count":36,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYGD18022"],"award-info":[{"award-number":["ZYGD18022"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Primary adrenal lymphoma (PAL) is difficult to distinguish from other adrenal masses. Soluble interleukin-2 receptor (sIL-2R) is a diagnostic biomarker for nodal non-Hodgkin lymphoma, whose association with PAL is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to determine the diagnostic utility of serum sIL-2R for Patients with PAL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Prospective cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Settings and Participants<\/jats:title>\n                  <jats:p>A total of 118 patients with adrenal masses who were willing to be tested for levels of serum sIL-2R from a tertiary hospital between 2019 and 2021 were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcomes and Measures<\/jats:title>\n                  <jats:p>Serum sIL-2R and lactate dehydrogenase (LDH) levels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients with PAL had significantly higher sIL-2R levels than those of patients with other adrenal masses with indetermined and benign computed tomography (CT) features (both Ps\u2005&amp;lt;\u20050.001). The LDH levels of patients with PAL were also significantly higher than those of patients with other adrenal masses with indeterminate and benign CT features (both Ps\u2005&amp;lt;\u20050.001). Good discrimination of patients with PAL from other patients (PAL vs other adrenal masses with indeterminate CT features\/non-PAL) was achieved with an area under the receiver operating characteristic curve (AUC) of 0.984 (95% CI, 0.95-1)\/0.992 (95% CI, 0.975-1.000) using the serum levels of sIL-2R and further improved (AUC\u2005=\u20050.998, 95% CI, 0.994-1.000; AUC\u2005=\u20050.999, 95% CI, 0.996-1.000) after adjusting by LDH category.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>For the first time, we have identified that serum sIL-2R and LDH category-adjusted sIL-2R levels have good diagnostic performances for PAL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac131","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T14:57:21Z","timestamp":1646665041000},"page":"e2284-e2290","source":"Crossref","is-referenced-by-count":3,"title":["sIL-2R: A Novel Diagnostic Biomarker for Primary Adrenal Lymphoma"],"prefix":"10.1210","volume":"107","author":[{"given":"Kai","family":"Yu","sequence":"first","affiliation":[{"name":"Adrenal Center, Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, P. 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