{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:08Z","timestamp":1791895568538,"version":"4.3.4"},"reference-count":54,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T00:00:00Z","timestamp":1647043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Parathyroidectomy (PTx) and cinacalcet are both effective treatments for secondary hyperparathyroidism in hemodialysis patients, but limited data exist comparing the long-term outcomes of these interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to compare the risk of mortality among hemodialysis patients who underwent PTx and those who started treatment with cinacalcet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study, comprising patients from the Japanese Society for Dialysis Therapy Renal Data Registry, patients who had intact parathyroid hormone (PTH) levels\u2005\u2265\u2005300 pg\/mL in late 2007 and underwent PTx or started treatment with cinacalcet in 2008 to 2009 were matched by propensity score at 1:3. PTx and cinacalcet were compared for all-cause mortality within 6 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among eligible patients, 894 patients who underwent PTx were matched with 2682 patients who started treatment with cinacalcet. The median baseline intact PTH levels were 588 pg\/mL and 566 pg\/mL in the PTx and cinacalcet groups, respectively. PTx resulted in greater reductions in intact PTH, calcium, and phosphorus levels compared with cinacalcet. During the 6-year follow-up period, 201 patients (22.5%) in the PTx group and 736 patients (27.4%) in the cinacalcet group died. PTx was associated with a lower risk of mortality compared with cinacalcet (hazard ratio, 0.78 [95% CI, 0.67-0.91]; P\u2005=\u20050.002). This association was more pronounced in patients with intact PTH levels\u2005\u2265\u2005500 pg\/mL and in patients with serum calcium levels\u2005\u2265\u200510.0 mg\/dL (both P for interaction\u2005&amp;lt;\u20050.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PTx compared with cinacalcet is associated with a lower risk of mortality, particularly among patients with severe secondary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac142","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T07:02:24Z","timestamp":1647068544000},"page":"2016-2025","source":"Crossref","is-referenced-by-count":53,"title":["Parathyroidectomy vs Cinacalcet Among Patients Undergoing Hemodialysis"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1704-4507","authenticated-orcid":false,"given":"Hirotaka","family":"Komaba","sequence":"first","affiliation":[{"name":"Committee of Renal Data Registry, Japanese Society for Dialysis Therapy , Tokyo , Japan"},{"name":"Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine , Isehara , Japan"},{"name":"The Institute of Medical Sciences, Tokai University , Isehara , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Hamano","sequence":"additional","affiliation":[{"name":"Committee of Renal Data Registry, Japanese Society for Dialysis Therapy , Tokyo , Japan"},{"name":"Department of Nephrology, Nagoya City University Graduate School of Medical Sciences , Nagoya , Japan"},{"name":"Department of Nephrology, Osaka University Graduate School of Medicine , Suita , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiko","family":"Fujii","sequence":"additional","affiliation":[{"name":"Committee of Renal Data Registry, Japanese Society for Dialysis Therapy , Tokyo , Japan"},{"name":"Department of Nephrology, Hyogo Prefectural Nishinomiya Hospital , Nishinomiya , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Comprehensive Unit for Health Economic Evidence Review and Decision Support (CHEERS), Research Organization of Science and Technology, Ritsumeikan University , Kyoto , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Wada","sequence":"additional","affiliation":[{"name":"Committee of Renal Data Registry, Japanese Society for Dialysis Therapy , Tokyo , Japan"},{"name":"Department of Nephrology, Kitasaito Hospital , Asahikawa , 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