{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:05:20Z","timestamp":1789153520729,"version":"build-2803163510"},"reference-count":71,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01 DK068001"],"award-info":[{"award-number":["R01 DK068001"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM121081-08"],"award-info":[{"award-number":["R01GM121081-08"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["NIH-R01DK128416"],"award-info":[{"award-number":["NIH-R01DK128416"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Clinical and Translational Sciences Institute","award":["KL2-TR002534"],"award-info":[{"award-number":["KL2-TR002534"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Metabolic endotoxemia may be a shared mechanism underlying childhood obesity and early-onset metabolic diseases (eg, type 2 diabetes, nonalcoholic fatty liver disease).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Examine prospective associations of serum endotoxin biomarkers lipopolysaccharide (LPS) and its binding protein, LPS binding protein (LBP), and anti-endotoxin core immunoglobulin G (EndoCab IgG) with adiposity and cardiometabolic risk in youth.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design\/setting<\/jats:title>\n                  <jats:p>This prospective study included 393 youth in the Exploring Perinatal Outcomes Among Children cohort in Colorado. Participants were recruited from 2006 to 2009 at age 10 years (baseline) and followed for 6 years (follow-up). We examined associations of endotoxin biomarkers at baseline with adiposity [body mass index (BMI) z-score, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), skinfolds, waist circumference] and cardiometabolic risk (insulin, glucose, adipokines, lipid profile, blood pressure) across both visits using mixed-effects regression, and with hepatic fat fraction (HFF) at follow-up using linear regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Higher LPS and LBP predicted greater adiposity across follow-up. Each 1-unit log-transformed LPS corresponded with 0.23 (95% CI 0.03, 0.43) units BMI z-score, 5.66 (95% CI 1.99, 9.33) mm3 VAT, 30.7 (95% CI 8.0, 53.3) mm3 SAT, and 8.26 (95% CI 4.13, 12.40) mm skinfold sum. EndoCab IgG was associated with VAT only [3.03 (95% CI 0.34, 5.71) mm3]. LPS was associated with higher insulin [1.93 (95% CI 0.08, 3.70) \u00b5U\/mL] and leptin [2.28 (95% CI 0.66, 3.90) ng\/mL] and an adverse lipid profile. No association was observed with HFF. Accounting for pubertal status and lifestyle behaviors did not change findings. However, adjustment for prepregnancy BMI and gestational diabetes attenuated most associations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Serum endotoxin may be a marker of pathophysiological processes underlying development of childhood obesity and cardiometabolic conditions associated with exposure to fetal overnutrition.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac149","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T18:30:35Z","timestamp":1647023435000},"page":"e3018-e3028","source":"Crossref","is-referenced-by-count":10,"title":["Endotoxin Biomarkers Are Associated With Adiposity and Cardiometabolic Risk Across 6 Years of Follow-up in Youth"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8552-6850","authenticated-orcid":false,"given":"Wei","family":"Perng","sequence":"first","affiliation":[{"name":"Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus , Aurora CO , USA"},{"name":"Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus , CO , USA"},{"name":"Department of Nutritional Sciences, University of Michigan School of Public Health , Ann Arbor, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob E","family":"Friedman","sequence":"additional","affiliation":[{"name":"Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, School of Medicine , Oklahoma City, OK , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel C","family":"Janssen","sequence":"additional","affiliation":[{"name":"Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, School of Medicine , Oklahoma City, OK , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah H","family":"Glueck","sequence":"additional","affiliation":[{"name":"Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus , Aurora CO , USA"},{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9514-8929","authenticated-orcid":false,"given":"Dana","family":"Dabelea","sequence":"additional","affiliation":[{"name":"Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus , Aurora CO , USA"},{"name":"Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus , CO , USA"},{"name":"Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"issue":"10","key":"2022061616004291700_CIT0001","doi-asserted-by":"crossref","first-page":"e0140908","DOI":"10.1371\/journal.pone.0140908","article-title":"The prevalence of non-alcoholic fatty liver disease in children and adolescents: a systematic review and meta-analysis","volume":"10","author":"Anderson","year":"2015","journal-title":"PLoS One."},{"issue":"15","key":"2022061616004291700_CIT0002","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJMoa1610187","article-title":"Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012","volume":"376","author":"Mayer-Davis","year":"2017","journal-title":"N Engl J 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