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Sanidad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016145","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Servicios Sociales e Igualdad"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Adrenocorticotropin (ACTH)-secreting pituitary tumors (ACTHomas) are associated with severe comorbidities and increased mortality. Current treatments mainly focus on remission and prevention of persistent disease and recurrence. However, there are still no useful biomarkers to accurately predict the clinical outcome after surgery, long-term remission, or disease relapse.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This work aimed to identify clinical, biochemical, and molecular markers for predicting long-term clinical outcome and remission in ACTHomas.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective multicenter study was performed with 60 ACTHomas patients diagnosed between 2004 and 2018 with at least 2 years\u2019 follow-up. Clinical\/biochemical variables were evaluated yearly. Molecular expression profile of the somatostatin\/ghrelin\/dopamine regulatory systems components and of key pituitary factors and proliferation markers were evaluated in tumor samples after the first surgery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Clinical variables including tumor size, time until diagnosis\/first surgery, serum prolactin, and postsurgery cortisol levels were associated with tumor remission and relapsed disease. The molecular markers analyzed were distinctly expressed in ACTHomas, with some components (ie, SSTR1, CRHR1, and MKI67) showing instructive associations with recurrence and\/or remission. Notably, an integrative model including selected clinical variables (tumor size\/postsurgery serum cortisol), and molecular markers (SSTR1\/CRHR1) can accurately predict the clinical evolution and remission of patients with ACTHomas, generating a receiver operating characteristic curve with an area under the curve of 1 (P\u2005&amp;lt;\u2005.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study demonstrates that the combination of a set of clinical and molecular biomarkers in ACTHomas is able to accurately predict the clinical evolution and remission of patients. Consequently, the postsurgery molecular profile represents a valuable tool for clinical evaluation and follow-up of patients with ACTHomas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac172","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T14:22:09Z","timestamp":1647872529000},"page":"e2938-e2951","source":"Crossref","is-referenced-by-count":8,"title":["Integrative Clinical, Radiological, and Molecular Analysis for Predicting Remission and Recurrence of Cushing Disease"],"prefix":"10.1210","volume":"107","author":[{"given":"Paloma","family":"Moreno-Moreno","sequence":"first","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) , 14004 Cordoba , Spain"},{"name":"Reina Sofia University Hospital (HURS) , 14004 Cordoba , Spain"},{"name":"Service of Endocrinology and Nutrition, IMIBIC, HURS , 14004 Cordoba , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Ib\u00e1\u00f1ez-Costa","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) , 14004 Cordoba , Spain"},{"name":"Reina Sofia University Hospital (HURS) , 14004 Cordoba , Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, University of Cordoba , 14004 Cordoba , Spain"},{"name":"CIBER Physiopathology of Obesity and Nutrition (CIBERobn) , 14004 Cordoba , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Venegas-Moreno","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n de Endocrinolog\u00eda y Nutrici\u00f3n. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Roc\u00edo\/CSIC\/Universidad de Sevilla, 41013 Sevilla , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio C","family":"Fuentes-Fayos","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) , 14004 Cordoba , Spain"},{"name":"Reina Sofia University Hospital (HURS) , 14004 Cordoba , Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, University of Cordoba , 14004 Cordoba , Spain"},{"name":"CIBER Physiopathology of Obesity and Nutrition (CIBERobn) , 14004 Cordoba , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda R","family":"Alhambra-Exp\u00f3sito","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) , 14004 Cordoba , Spain"},{"name":"Reina Sofia University Hospital (HURS) , 14004 Cordoba , Spain"},{"name":"Service of Endocrinology and Nutrition, IMIBIC, HURS , 14004 Cordoba , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Fajardo-Monta\u00f1ana","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital Universitario de La Ribera, Alzira , 46600, Valencia , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Araceli","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Maimonides Biomedical Research Institute of Cordoba (IMIBIC) , 14004 Cordoba , Spain"},{"name":"Reina Sofia University Hospital (HURS) , 14004 Cordoba , Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, University of Cordoba , 14004 Cordoba , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Dios","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n de Endocrinolog\u00eda y Nutrici\u00f3n. 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Institute for Health and Biomedical Research (ISABIAL). University Miguel Hernandez , CIBER Rare Diseases, 03010, Alicante , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Soto-Moreno","sequence":"additional","affiliation":[{"name":"Unidad de Gesti\u00f3n de Endocrinolog\u00eda y Nutrici\u00f3n. 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