{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:28:49Z","timestamp":1785270529830,"version":"3.55.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M027252\/1"],"award-info":[{"award-number":["BB\/M027252\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018956","name":"NIHR Cambridge Biomedical Research Centre","doi-asserted-by":"publisher","award":["IS-BRC-1215-20014"],"award-info":[{"award-number":["IS-BRC-1215-20014"]}],"id":[{"id":"10.13039\/501100018956","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["14\/0004849"],"award-info":[{"award-number":["14\/0004849"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"publisher","award":["17\/0005712"],"award-info":[{"award-number":["17\/0005712"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tommy\u2019s Charity"},{"DOI":"10.13039\/501100001648","name":"European Foundation for the Study of Diabetes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF19SA058974"],"award-info":[{"award-number":["NNF19SA058974"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["RP-PG-0407-10452"],"award-info":[{"award-number":["RP-PG-0407-10452"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L002477\/1"],"award-info":[{"award-number":["MR\/L002477\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014589","name":"Chief Scientist Office, Scottish Government Health Directorates","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014589","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015250","name":"NIHR Bristol Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015250","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cambridge University Hospitals NHS Foundation Trust"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Gestational diabetes (GDM) affects 20 million women\/year worldwide and is associated with childhood obesity. Infants of affected mothers have increased adiposity from birth, which leads to obesity in later life. However, it remains unknown whether the effect of GDM upon neonatal body composition is due to hyperglycemia alone or is mediated by other pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate plasma lipid profiles in obese women according to GDM diagnosis, infant birthweight percentiles, and adiposity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective cohort from UPBEAT trial (ISRCTN 89971375).<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Hospital and community.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>867 obese pregnant women recruited in early pregnancy, assessed at 28 weeks for GDM. Offspring anthropometry was assessed at birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome (Prespecified)<\/jats:title><jats:p>Neonatal birth percentile and abdominal circumference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Lipidomic profiling in the fasting plasma oral glucose tolerance test sample using direct infusion mass spectrometry. Analysis included logistic\/linear regression, unadjusted and adjusted for maternal age, body mass index, parity, ethnicity, UPBEAT trial arm, and fetal sex. The limit of significance was P\u2005=\u20050.05 for offspring anthropometry and P\u2005=\u20050.002 for lipidomic data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GDM in obese women was associated with elevated plasma concentrations of specific diglycerides [DG(32:0)] and triglycerides [TG(48:0), (50:1), (50:2)] containing fatty acids (16:0), (16:1), (18:0), and (18:1), consistent with increased de novo lipogenesis. In the whole cohort, these species were associated with birthweight percentile and neonatal abdominal circumference. Effects upon infant abdominal circumference remained significant after adjustment for maternal glycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased de novo lipogenesis-related species in pregnant women with obesity and GDM are associated with measures of offspring adiposity and may be a target for improving lifelong health.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgac206","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:45:48Z","timestamp":1648763148000},"page":"e2825-e2832","source":"Crossref","is-referenced-by-count":39,"title":["Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-2051","authenticated-orcid":false,"given":"Samuel","family":"Furse","sequence":"first","affiliation":[{"name":"Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke\u2019s Treatment Centre, Keith Day Road Cambridge , CB2 0QQ , UK"},{"name":"Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke\u2019s Treatment Centre , Keith Day Road Cambridge, CB2 0QQ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9998-051X","authenticated-orcid":false,"given":"Albert","family":"Koulman","sequence":"additional","affiliation":[{"name":"Core Metabolomics and Lipidomics Laboratory, Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke\u2019s Treatment Centre, Keith Day Road Cambridge , CB2 0QQ , UK"},{"name":"Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke\u2019s Treatment Centre , Keith Day Road Cambridge, CB2 0QQ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-5144","authenticated-orcid":false,"given":"Susan E","family":"Ozanne","sequence":"additional","affiliation":[{"name":"Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke\u2019s Treatment Centre , Keith Day Road Cambridge, CB2 0QQ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucilla","family":"Poston","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Lifecourse and Population Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London SE1 7EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-0508","authenticated-orcid":false,"given":"Sara L","family":"White","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Lifecourse and Population Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London , London SE1 7EH , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4176-8329","authenticated-orcid":false,"given":"Claire L","family":"Meek","sequence":"additional","affiliation":[{"name":"Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke\u2019s Treatment Centre , Keith Day Road Cambridge, CB2 0QQ , UK"},{"name":"Department of Clinical Biochemistry\/Wolfson Diabetes & Endocrine Clinic, Cambridge University Hospitals NHS Foundation Trust , Cambridge CB2 0QQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"2022121620481945300_CIT0001","doi-asserted-by":"crossref","first-page":"e0144027","DOI":"10.1371\/journal.pone.0144027","article-title":"Lipid fingerprinting in mild versus severe forms of gestational diabetes mellitus","volume":"10","author":"Gueuvoghlanian-Silva","year":"2015","journal-title":"PLoS One."},{"issue":"suppl 2","key":"2022121620481945300_CIT0002","first-page":"B161","article-title":"Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee","volume":"21","author":"Metzger","year":"1998","journal-title":"Diabetes Care."},{"key":"2022121620481945300_CIT0003","article-title":"Plasma lipidomics profile in pregnancy and gestational diabetes risk: a prospective study in a multiracial\/ethnic cohort","volume":"9(1)","author":"Rahman","year":"2021","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2022121620481945300_CIT0004","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12916-018-1248-7","article-title":"The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial","volume":"17","author":"Mills","year":"2019","journal-title":"BMC Med."},{"key":"2022121620481945300_CIT0005","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1007\/s00125-017-4380-6","article-title":"Metabolic profiling of gestational diabetes in obese women during pregnancy","volume":"60","author":"White","year":"2017","journal-title":"Diabetologia."},{"key":"2022121620481945300_CIT0006","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1039\/C9MO00117D","article-title":"Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy","volume":"15","author":"Furse","year":"2019","journal-title":"Molecular Omics."},{"key":"2022121620481945300_CIT0007","doi-asserted-by":"crossref","first-page":"e0230658","DOI":"10.1371\/journal.pone.0230658","article-title":"Metabolic phenotyping by treatment modality in obese women with gestational diabetes suggests diverse pathophysiology: An exploratory study","volume":"15","author":"White","year":"2020","journal-title":"PLoS One."},{"key":"2022121620481945300_CIT0008","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2337\/db15-1748","article-title":"Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth","volume":"65","author":"Scholtens","year":"2016","journal-title":"Diabetes."},{"key":"2022121620481945300_CIT0009","doi-asserted-by":"crossref","first-page":"2706","DOI":"10.2337\/dc12-2445","article-title":"Maternal lipids are as important as glucose for fetal growth: findings from the Pune Maternal Nutrition study","volume":"36","author":"Kulkarni","year":"2013","journal-title":"Diabetes Care."},{"key":"2022121620481945300_CIT0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1464-5491.2004.01336.x","article-title":"Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance","volume":"22","author":"Di Cianni","year":"2005","journal-title":"Diabet Med."},{"key":"2022121620481945300_CIT0011","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.placenta.2018.05.011","article-title":"Altered maternal and placental lipid metabolism and fetal fat development in obesity: current knowledge and advances in non-invasive assessment","volume":"69","author":"Delhaes","year":"2018","journal-title":"Placenta."},{"key":"2022121620481945300_CIT0012","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.3390\/nu12103031","article-title":"The impact of maternal body composition and dietary fat consumption upon placental lipid processing and offspring metabolic health","volume":"12","author":"Easton","year":"2020","journal-title":"Nutrients."},{"key":"2022121620481945300_CIT0013","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.placenta.2014.03.010","article-title":"Oxidative stress and maternal obesity: feto-placental unit interaction","volume":"35","author":"Malti","year":"2014","journal-title":"Placenta."},{"key":"2022121620481945300_CIT0014","doi-asserted-by":"crossref","first-page":"902","DOI":"10.2337\/dc16-2452","article-title":"Maternal BMI and glycemia impact the fetal metabolome","volume":"40","author":"Lowe","year":"2017","journal-title":"Diabetes Care."},{"key":"2022121620481945300_CIT0015","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00404-017-4573-8","article-title":"Maternal pre-pregnancy obesity and the risk of macrosomia: a meta-analysis","volume":"297","author":"Dai","year":"2018","journal-title":"Arch Gynecol Obstet."},{"key":"2022121620481945300_CIT0016","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1021\/acs.jproteome.8b00786","article-title":"An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors","volume":"18","author":"Harshfield","year":"2019","journal-title":"J Proteome Res."},{"key":"2022121620481945300_CIT0017","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/(SICI)1096-9888(199701)32:1<81::AID-JMS454>3.0.CO;2-2","article-title":"Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic\/mass spectrometric techniques","volume":"32","author":"Diraison","year":"1997","journal-title":"J Mass Spectrom."},{"key":"2022121620481945300_CIT0018","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S2213-8587(15)00227-2","article-title":"Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial","volume":"3","author":"Poston","year":"2015","journal-title":"Lancet Diabetes Endocrinol."},{"key":"2022121620481945300_CIT0019","doi-asserted-by":"crossref","first-page":"e6261","DOI":"10.1371\/journal.pone.0006261","article-title":"Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients","volume":"4","author":"Graessler","year":"2009","journal-title":"PLoS One."},{"key":"2022121620481945300_CIT0020","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","article-title":"Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics","volume":"49","author":"Matyash","year":"2008","journal-title":"J Lipid Res."},{"key":"2022121620481945300_CIT0021","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"2022121620481945300_CIT0022","article-title":"Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption","volume":"19(1):79","author":"Sanders","year":"2018","journal-title":"Genome Biol."},{"key":"2022121620481945300_CIT0023","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/oby.22246","article-title":"Postprandial triglycerides predict newborn fat more strongly than glucose in women with obesity in early pregnancy","volume":"26","author":"Barbour","year":"2018","journal-title":"Obesity (Silver Spring)."},{"key":"2022121620481945300_CIT0024","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11892-018-1008-2","article-title":"Maternal non-glycemic contributors to fetal growth in obesity and gestational diabetes: spotlight on lipids","volume":"18","author":"Barbour","year":"2018","journal-title":"Curr Diab Rep."},{"key":"2022121620481945300_CIT0025","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1194\/jlr.P082628","article-title":"Racial differences in in vivo adipose lipid kinetics in humans","volume":"59","author":"White","year":"2018","journal-title":"J Lipid Res."},{"key":"2022121620481945300_CIT0026","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/ajcn\/nqaa055","article-title":"Maternal glycemia during pregnancy and offspring abdominal adiposity measured by MRI in the neonatal period and preschool years: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective mother-offspring birth cohort study","volume":"112","author":"Tint","year":"2020","journal-title":"Am J Clin Nutr."},{"key":"2022121620481945300_CIT0027","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/pr.2013.193","article-title":"Developmental origins of nonalcoholic fatty liver disease","volume":"75","author":"Brumbaugh","year":"2014","journal-title":"Pediatr Res."},{"key":"2022121620481945300_CIT0028","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/MCO.0000000000000469","article-title":"Dietary carbohydrates and fatty liver disease: de novo lipogenesis","volume":"21","author":"Chiu","year":"2018","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"2022121620481945300_CIT0029","doi-asserted-by":"crossref","first-page":"e1003102","DOI":"10.1371\/journal.pmed.1003102","article-title":"Fatty acids in the de novo lipogenesis pathway and incidence of type 2 diabetes: a pooled analysis of prospective cohort studies","volume":"17","author":"Imamura","year":"2020","journal-title":"PLoS Med."},{"key":"2022121620481945300_CIT0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1515\/hmbci-2015-0025","article-title":"Maternal and fetal lipid metabolism under normal and gestational diabetic conditions","volume":"26","author":"Herrera","year":"2016","journal-title":"Horm Mol Biol Clin Investig."},{"key":"2022121620481945300_CIT0031","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1471-0528.1975.tb00672.x","article-title":"Carbohydrate-induced lipogenesis in the human placenta of normal and diabetic pregnancies","volume":"82","author":"Coltart","year":"1975","journal-title":"Br J Obstet Gynaecol."},{"key":"2022121620481945300_CIT0032","doi-asserted-by":"crossref","first-page":"209e201","DOI":"10.1016\/j.ajog.2009.04.019","article-title":"Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus","volume":"201","author":"Radaelli","year":"2009","journal-title":"Am J Obstet Gynecol."},{"key":"2022121620481945300_CIT0033","doi-asserted-by":"crossref","first-page":"E463","DOI":"10.1152\/ajpendo.00449.2016","article-title":"Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis","volume":"313","author":"Nikolova","year":"2017","journal-title":"Am J Physiol Endocrinol Metab."},{"key":"2022121620481945300_CIT0034","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/oby.2003.150","article-title":"Effect of carbohydrate overfeeding on whole body and adipose tissue metabolism in humans","volume":"11","author":"Minehira","year":"2003","journal-title":"Obes Res."},{"key":"2022121620481945300_CIT0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/humupd\/dmt013","article-title":"Genetic variants and the risk of gestational diabetes mellitus: a systematic review","volume":"19","author":"Zhang","year":"2013","journal-title":"Hum Reprod Update."},{"key":"2022121620481945300_CIT0036","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2337\/db20-0772","article-title":"Genetic loci and physiologic pathways involved in gestational diabetes mellitus implicated through clustering","volume":"70","author":"Powe","year":"2021","journal-title":"Diabetes."},{"key":"2022121620481945300_CIT0037","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0378-3782(78)90004-X","article-title":"Lipogenesis in developing human adipose tissue","volume":"2","author":"Dunlop","year":"1978","journal-title":"Early Hum Dev."},{"key":"2022121620481945300_CIT0038","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1194\/jlr.P072355","article-title":"The influence of placental metabolism on fatty acid transfer to the fetus","volume":"58","author":"Perazzolo","year":"2017","journal-title":"J Lipid Res."},{"key":"2022121620481945300_CIT0039","doi-asserted-by":"crossref","first-page":"E1098","DOI":"10.1152\/ajpendo.00481.2002","article-title":"Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases","volume":"284","author":"Shekhawat","year":"2003","journal-title":"Am J Physiol Endocrinol."},{"key":"2022121620481945300_CIT0040","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1002\/mrd.20842","article-title":"Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta","volume":"75","author":"Marseille-Tremblay","year":"2008","journal-title":"Mol Reprod Dev."},{"key":"2022121620481945300_CIT0041","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jhep.2009.12.042","article-title":"Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice","volume":"52","author":"Oben","year":"2010","journal-title":"J Hepatol."},{"key":"2022121620481945300_CIT0042","doi-asserted-by":"crossref","first-page":"e12725","DOI":"10.1111\/ijpo.12725","article-title":"Adiposity and cardiovascular outcomes in three-year-old children of participants in UPBEAT, an RCT of a complex intervention in pregnant women with obesity","volume":"16","author":"Dalrymple","year":"2021","journal-title":"Pediatr Obes."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac206\/43518364\/dgac206.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/7\/e2825\/48030509\/dgac206.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/7\/e2825\/48030509\/dgac206.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:53:47Z","timestamp":1700402027000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/7\/e2825\/6561850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,31]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,3,31]]},"published-print":{"date-parts":[[2022,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac206","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,3,31]]}}}