{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T01:35:19Z","timestamp":1781228119393,"version":"3.54.1"},"reference-count":18,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The impact of heavier weight of resected thyroid specimen on postoperative morbidity after total thyroidectomy for multinodular benign goiter remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from the prospective StuDoQ|Thyroid registry of the German Society of General and Visceral Surgery were analyzed regarding the weight of the resected thyroid specimen and perioperative morbidity (vocal cord palsy, hemorrhage, surgical site infection, and hypocalcemia). To achieve a homogeneous patient population, only patients with total thyroidectomy for multinodular benign goiter were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 7911 patients from 105 departments underwent total thyroidectomy for benign conditions (January 2017-July 2020). The median resected weight of the thyroid specimen in all patients was 53 g (interquartile range 32-92). In 1732 patients, the specimen weight exceeded 100 g. Intraoperative neuromonitoring was used in 99.5% of patients. Postoperative laryngoscopy revealed vocal cord dysfunction in 480 of 15 822 (3.03%) nerves at risk, with unilateral dysfunction in 454 (2.87%) of patients and bilateral dysfunction in 13 patients (0.08%). In multivariable analysis, a thyroid weight &amp;gt;100 g was an independent predictor of early postoperative vocal cord dysfunction [odds ratio (OR) 1.462, 95% CI 1.108-1.930, P\u2005=\u20050.007). Heavier (&amp;gt;100 g) thyroid weight was an independent predictor of surgical site infection (OR 1.861, 95% CI 1.203-2.880, P\u2005=\u20050.005) and also predicted postoperative hemorrhage in the univariate analysis (OR 1.723, 95% CI 1.027-2.889, P\u2005=\u20050.039). On the contrary, postoperative parathyroid function was not affected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Heavier (&amp;gt;100 g) resected thyroid weight independently predicts higher postoperative morbidity, including early vocal cord palsy and surgical site infection after total thyroidectomy for benign multinodular goiter.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac214","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T17:42:14Z","timestamp":1649353334000},"page":"e2762-e2769","source":"Crossref","is-referenced-by-count":6,"title":["Heavier Weight of Resected Thyroid Specimen Is Associated With Higher Postoperative Morbidity in Benign Goiter"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9091-736X","authenticated-orcid":false,"given":"Ioannis","family":"Mintziras","sequence":"first","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, Section of Endocrine Surgery, Philipps-University Marburg, Marburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Ringelband","sequence":"additional","affiliation":[{"name":"Department of Surgery, St. Joseph-Stift Dresden , Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"J\u00e4hne","sequence":"additional","affiliation":[{"name":"Department of General and Visceral Surgery, DIAKOVERE Friederikenstift , Hannover , Hannover , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Vorl\u00e4nder","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, B\u00fcrgerhospital Frankfurt\/Main , Frankfurt am Main , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Dotzenrath","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Helios University Hospital Wuppertal , Wuppertal , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Zielke","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Diakonie-Klinikum Stuttgart , Stuttgart , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Klinger","sequence":"additional","affiliation":[{"name":"German Society of General and Visceral Surgery (DGAV) , Berlin , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Holzer","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, Section of Endocrine Surgery, Philipps-University Marburg, Marburg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"issue":"5","key":"2022061616000015900_CIT0001","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00423-011-0774-y","article-title":"German Association of Endocrine Surgeons practice guidelines for the surgical treatment of benign thyroid disease","volume":"396","author":"Musholt","year":"2011","journal-title":"Langenbecks Arch Surg."},{"issue":"6","key":"2022061616000015900_CIT0002","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1089\/thy.2016.0500","article-title":"Postoperative outcomes in Graves\u2019 disease patients: results from the nationwide inpatient sample database","volume":"27","author":"Rubio","year":"2017","journal-title":"Thyroid."},{"issue":"11","key":"2022061616000015900_CIT0003","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s002680010221","article-title":"Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: prospective multicenter study in Germany","volume":"24","author":"Thomusch","year":"2000","journal-title":"World J Surg."},{"issue":"1","key":"2022061616000015900_CIT0004","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00104-020-01191-x","article-title":"Case volume and complications after thyroid gland surgery in Germany: an analysis of routine data from 48,387 AOK patients","volume":"92","author":"Maneck","year":"2021","journal-title":"Chirurg."},{"issue":"2","key":"2022061616000015900_CIT0005","article-title":"The relation between preoperative ultrasonographic thyroid volume analysis and thyroidectomy complications","volume":"43","author":"Karabeyoglu","year":"2009","journal-title":"Endocr Regul."},{"issue":"4","key":"2022061616000015900_CIT0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm8040477","article-title":"Current practice of surgery for benign goitre\u2014an analysis of the prospective DGAV stuDoQ|thyroid registry","volume":"8","author":"Bartsch","year":"2019","journal-title":"J Clin Med."},{"issue":"12","key":"2022061616000015900_CIT0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9124014","article-title":"Short-term outcomes of surgery for Graves\u2019 disease in Germany","volume":"9","author":"Maurer","year":"2020","journal-title":"J Clin Med."},{"issue":"3","key":"2022061616000015900_CIT0008","article-title":"Risk factors in recurrent nerve paralysis: a statistical analysis of 7566 cases of struma surgery","volume":"62","author":"Hermann","year":"1991","journal-title":"Chirurg."},{"issue":"2","key":"2022061616000015900_CIT0009","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.surg.2014.03.015","article-title":"Risk factors for hematoma after thyroidectomy: results from the nationwide inpatient sample","volume":"156","author":"Weiss","year":"2014","journal-title":"Surg."},{"issue":"4","key":"2022061616000015900_CIT0010","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s00268-019-05322-2","article-title":"Reoperation for bleeding after thyroid and parathyroid surgery: incidence, risk factors, prevention, and management","volume":"44","author":"Edafe","year":"2020","journal-title":"World J Surg."},{"issue":"3","key":"2022061616000015900_CIT0011","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/bjs.7824","article-title":"Risk factors for postoperative bleeding after thyroid surgery","volume":"99","author":"Promberger","year":"2012","journal-title":"Br J Surg."},{"issue":"7","key":"2022061616000015900_CIT0012","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1093\/bjs\/znab015","article-title":"Post-thyroidectomy bleeding: analysis of risk factors from a national registry","volume":"108","author":"Doran","year":"2021","journal-title":"Br J Surg."},{"key":"2022061616000015900_CIT0013","first-page":"1945","article-title":"Post-thyroidectomy hemorrhage: a national study of patients treated at the Danish departments of ENT Head and Neck Surgery","author":"Godballe","year":"2009"},{"issue":"7","key":"2022061616000015900_CIT0014","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s00423-019-01836-4","article-title":"Evaluating risk factors for re-exploration due to postoperative neck hematoma after thyroid surgery: a nested case-control study","volume":"404","author":"Salem","year":"2019","journal-title":"Langenbecks Arch Surg."},{"issue":"3","key":"2022061616000015900_CIT0015","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1177\/0194599820947700","article-title":"Antibiotic prophylaxis for thyroid and parathyroid surgery: a systematic review and meta-analysis","volume":"164","author":"Medas","year":"2021","journal-title":"Otolaryngol Head Neck Surg."},{"issue":"7","key":"2022061616000015900_CIT0016","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00423-012-0976-y","article-title":"Vascular clips versus ligatures in thyroid surgery\u2014results of a multicenter randomized controlled trial (CLIVIT trial)","volume":"397","author":"Diener","year":"2012","journal-title":"Langenbecks Arch Surg."},{"issue":"5","key":"2022061616000015900_CIT0017","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00423-008-0366-7","article-title":"Complications to thyroid surgery: results as reported in a database from a multicenter audit comprising 3,660 patients","volume":"393","author":"Bergenfelz","year":"2008","journal-title":"Langenbecks Arch Surg."},{"key":"2022061616000015900_CIT0018","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.ijsu.2008.12.024","article-title":"Surveillance of surgical site infections after thyroidectomy in a one-day surgery setting","volume":"6","author":"Dionigi","year":"2008","journal-title":"Int J Surg."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac214\/43687650\/dgac214.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/7\/e2762\/44110375\/dgac214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/7\/e2762\/44110375\/dgac214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T16:00:29Z","timestamp":1655395229000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/7\/e2762\/6564843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4,7]]},"published-print":{"date-parts":[[2022,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac214","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,4,7]]}}}