{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:11:08Z","timestamp":1781752268096,"version":"3.54.5"},"reference-count":49,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"US Food and Drug Administration","award":["R01 FD003902"],"award-info":[{"award-number":["R01 FD003902"]}]},{"name":"US Food and Drug Administration","award":["R01 FD005114"],"award-info":[{"award-number":["R01 FD005114"]}]},{"name":"National Institutes of Health\/National Institute of Arthritis and Musculoskeletal and Skin Diseases","award":["K24 AR052665"],"award-info":[{"award-number":["K24 AR052665"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Premenopausal women with idiopathic osteoporosis (PreMenIOP) have marked deficits in bone density, microstructure, and strength.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To define effects of treatment with teriparatide followed by denosumab on lumbar spine (LS) volumetric bone mineral density (vBMD) and stiffness by finite element analysis assessed on central quantitative computed tomography (cQCT) scans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design, Settings, and Participants<\/jats:title>\n                  <jats:p>Ancillary analysis of baseline, post-teriparatide, and post-denosumab cQCT scans from a randomized trial of 41 women allocated to teriparatide (20 mcg daily; n\u2005=\u200528) or placebo (n\u2005=\u200511). After 6 months, those on teriparatide continued for 18 months, and those on placebo switched to teriparatide for 24 months. After completing teriparatide, 33 enrolled in a Phase 2B extension with denosumab (60 mg every 6 months) for 12 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Primary outcomes were percentage change from baseline in LS trabecular vBMD and stiffness after teriparatide and between end of teriparatide and completing denosumab. Percentage change from baseline in LS trabecular vBMD and stiffness after sequential teriparatide and denosumab were secondary outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings<\/jats:title>\n                  <jats:p>There were large increases (all Ps\u2005&amp;lt;\u20050.001) in trabecular vBMD (25%), other vBMD parameters, and stiffness (21%) after teriparatide. Statistically significant increases in trabecular vBMD (10%; P\u2005&amp;lt;\u20050.001) and other vBMD parameters (P\u2005=\u20050.03-0.001) were seen after denosumab, while stiffness increased by 7% (P\u2005=\u20050.068). Sequential teriparatide and denosumab led to highly significant (all Ps\u2005&amp;lt;\u20050.001) increases LS trabecular vBMD (43%), other vBMD parameters (15-31%), and stiffness (21%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The large and statistically significant increases in volumetric density and stiffness after sequential treatment with teriparatide followed by denosumab are encouraging and support use of this regimen in PreMenIOP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac232","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T08:41:05Z","timestamp":1650098465000},"page":"e2690-e2701","source":"Crossref","is-referenced-by-count":11,"title":["Spine Volumetric BMD and Strength in Premenopausal Idiopathic Osteoporosis: Effect of Teriparatide Followed by Denosumab"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-0717","authenticated-orcid":false,"given":"Sanchita","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Shane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging, University of California San Francisco , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Shiau","sequence":"additional","affiliation":[{"name":"Department of Biostatistics & Epidemiology, Rutgers School of Public Health , Piscataway, NJ , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafo","family":"Kamanda-Kosseh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Bucovsky","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan M","family":"Lappe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Creighton University Medical Center , Omaha, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Stubby","sequence":"additional","affiliation":[{"name":"Department of Medicine, Creighton University Medical Center , Omaha, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R","family":"Recker","sequence":"additional","affiliation":[{"name":"Department of Medicine, Creighton University Medical Center , Omaha, NE , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexi","family":"Wang","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Edward Guo","sequence":"additional","affiliation":[{"name":"Bone Bioengineering Laboratory, Department of Biomedical Engineering, Columbia University , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adi","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Vagelos College of Physicians & Surgeons , New York, NY , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"issue":"1","key":"2022082005271296300_CIT0001","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00198-011-1560-y","article-title":"Premenopausal women with idiopathic low-trauma fractures and\/or low bone mineral density","volume":"23","author":"Cohen","year":"2012","journal-title":"Osteoporos Int."},{"issue":"11","key":"2022082005271296300_CIT0002","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1210\/jc.2009-0996","article-title":"Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis","volume":"94","author":"Cohen","year":"2009","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2022082005271296300_CIT0003","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1210\/jc.2011-1387","article-title":"Abnormal bone microarchitecture and evidence of osteoblast dysfunction in premenopausal women with idiopathic osteoporosis","volume":"96","author":"Cohen","year":"2011","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2022082005271296300_CIT0004","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1210\/jc.2012-2099","article-title":"Central QCT reveals lower volumetric BMD and stiffness in premenopausal women with idiopathic osteoporosis, regardless of fracture history","volume":"97","author":"Cohen","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"issue":"11","key":"2022082005271296300_CIT0005","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrendo.2011.108","article-title":"Parathyroid hormone analogues in the treatment of osteoporosis","volume":"7","author":"Kraenzlin","year":"2011","journal-title":"Nat Rev Endocrinol."},{"issue":"20","key":"2022082005271296300_CIT0006","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1056\/NEJMoa071408","article-title":"Teriparatide or alendronate in glucocorticoid-induced osteoporosis","volume":"357","author":"Saag","year":"2007","journal-title":"N Engl J Med."},{"issue":"9","key":"2022082005271296300_CIT0007","first-page":"3069","article-title":"Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers","volume":"85","author":"Kurland","year":"2000","journal-title":"J Clin Endocrinol Metab."},{"issue":"1","key":"2022082005271296300_CIT0008","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1359\/jbmr.2003.18.1.9","article-title":"The effect of teriparatide [human parathyroid hormone (1-34)] therapy on bone density in men with osteoporosis","volume":"18","author":"Orwoll","year":"2003","journal-title":"J Bone Miner Res."},{"issue":"5","key":"2022082005271296300_CIT0009","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1210\/jc.2013-1172","article-title":"Teriparatide for idiopathic osteoporosis in premenopausal women: a pilot study","volume":"98","author":"Cohen","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"10","key":"2022082005271296300_CIT0010","doi-asserted-by":"crossref","first-page":"e3540","DOI":"10.1210\/clinem\/dgaa489","article-title":"Effect of teriparatide on bone remodeling and density in premenopausal idiopathic osteoporosis: a Phase II trial","volume":"105","author":"Cohen","year":"2020","journal-title":"J Clin Endocrinol Metab."},{"issue":"9999","key":"2022082005271296300_CIT0011","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0140-6736(15)61120-5","article-title":"Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial","volume":"386","author":"Leder","year":"2015","journal-title":"Lancet."},{"issue":"4","key":"2022082005271296300_CIT0012","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.jocd.2017.05.007","article-title":"Effects of teriparatide, denosumab, or both on spine trabecular microarchitecture in DATA-switch: a randomized controlled trial","volume":"20","author":"Tsai","year":"2017","journal-title":"J Clin Densitom."},{"issue":"10","key":"2022082005271296300_CIT0013","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/jbmr.3198","article-title":"Effects of denosumab and teriparatide transitions on bone microarchitecture and estimated strength: the DATA-switch HR-pQCT study","volume":"32","author":"Tsai","year":"2017","journal-title":"J Bone Miner Res."},{"issue":"5","key":"2022082005271296300_CIT0014","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jbm4.10054","article-title":"Efficacy of switching from teriparatide to bisphosphonate or denosumab: a prospective, randomized, open-label trial","volume":"2","author":"Niimi","year":"2018","journal-title":"JBMR Plus."},{"issue":"11","key":"2022082005271296300_CIT0015","doi-asserted-by":"crossref","first-page":"4208","DOI":"10.1210\/jc.2015-2829","article-title":"Bone density after teriparatide discontinuation in premenopausal idiopathic osteoporosis","volume":"100","author":"Cohen","year":"2015","journal-title":"J Clin Endocrinol Metab."},{"key":"2022082005271296300_CIT0016","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgab850","article-title":"Denosumab after teriparatide in premenopausal women with idiopathic osteoporosis","author":"Shane","year":"2022;107(4):1528-1540","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2022082005271296300_CIT0017","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jbmr.3641","article-title":"Change in bone density and reduction in fracture risk: a meta-regression of published trials","volume":"34","author":"Bouxsein","year":"2019","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2022082005271296300_CIT0018","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0002-9343(01)01124-X","article-title":"Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs","volume":"112","author":"Cummings","year":"2002","journal-title":"Am J Med."},{"issue":"1","key":"2022082005271296300_CIT0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1359\/jbmr.2002.17.1.1","article-title":"Relationships between bone mineral density and incident vertebral fracture risk with raloxifene therapy","volume":"17","author":"Sarkar","year":"2002","journal-title":"J Bone Miner Res."},{"key":"2022082005271296300_CIT0020","first-page":"2651","volume-title":"The Use of Finite Element Analysis to Estimate the Changing Strength of Bone Following Treatment for Osteoporosis","author":"Burr","year":"2016"},{"issue":"6","key":"2022082005271296300_CIT0021","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1359\/JBMR.040307","article-title":"Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight","volume":"19","author":"Lang","year":"2004","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2022082005271296300_CIT0022","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.bone.2006.10.025","article-title":"Comparison of quantitative computed tomography-based measures in predicting vertebral compressive strength","volume":"40","author":"Buckley","year":"2007","journal-title":"Bone."},{"issue":"2","key":"2022082005271296300_CIT0023","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bone.2005.08.014","article-title":"Automated registration of hip and spine for longitudinal QCT studies: integration with 3D densitometric and structural analysis","volume":"38","author":"Li","year":"2006","journal-title":"Bone."},{"issue":"10","key":"2022082005271296300_CIT0024","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1002\/jbmr.111","article-title":"Bone density, geometry, microstructure, and stiffness: relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women","volume":"25","author":"Liu","year":"2010","journal-title":"J Bone Miner Res."},{"issue":"4","key":"2022082005271296300_CIT0025","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/S8756-3282(03)00210-2","article-title":"Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography","volume":"33","author":"Crawford","year":"2003","journal-title":"Bone."},{"issue":"437","key":"2022082005271296300_CIT0026","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/01.blo.0000164400.37905.22","article-title":"Predicting proximal femoral strength using structural engineering models","author":"Keyak","year":"2005","journal-title":"Clin Orthop Relat Res."},{"issue":"4","key":"2022082005271296300_CIT0027","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0736-0266(01)00185-1","article-title":"Quantitative computed tomography estimates of the mechanical properties of human vertebral trabecular bone","volume":"20","author":"Kopperdahl","year":"2002","journal-title":"J Orthop Res."},{"issue":"5","key":"2022082005271296300_CIT0028","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/jbmr.2734","article-title":"A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX","volume":"31","author":"McCloskey","year":"2016","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2022082005271296300_CIT0029","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jocd.2007.12.010","article-title":"Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions","volume":"11","author":"Engelke","year":"2008","journal-title":"J Clin Densitom."},{"issue":"2","key":"2022082005271296300_CIT0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00198-018-4716-1","article-title":"Prediction of incident vertebral fracture using CT-based finite element analysis","volume":"30","author":"Allaire","year":"2019","journal-title":"Osteoporos Int."},{"key":"2022082005271296300_CIT0031","article-title":"PTH treatment directly stimulates bone formation in cancellous and cortical bone in humans","author":"Dempster","year":"2001"},{"issue":"6","key":"2022082005271296300_CIT0032","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1359\/jbmr.060314","article-title":"Teriparatide increases bone formation in modeling and remodeling osteons and enhances IGF-II immunoreactivity in postmenopausal women with osteoporosis","volume":"21","author":"Ma","year":"2006","journal-title":"J Bone Miner Res."},{"issue":"7","key":"2022082005271296300_CIT0033","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1359\/JBMR.050309","article-title":"Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters","volume":"20","author":"Arlot","year":"2005","journal-title":"J Bone Miner Res."},{"issue":"7","key":"2022082005271296300_CIT0034","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1210\/jc.2014-1041","article-title":"Teriparatide increases strength of the peripheral skeleton in premenopausal women with idiopathic osteoporosis: a pilot HR-pQCT study","volume":"99","author":"Nishiyama","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"8","key":"2022082005271296300_CIT0035","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJMoa044459","article-title":"Denosumab in postmenopausal women with low bone mineral density","volume":"354","author":"McClung","year":"2006","journal-title":"N Engl J Med."},{"issue":"7","key":"2022082005271296300_CIT0036","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1359\/JBMR.040305","article-title":"A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women","volume":"19","author":"Bekker","year":"2004","journal-title":"J Bone Miner Res."},{"issue":"8","key":"2022082005271296300_CIT0037","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med."},{"issue":"4","key":"2022082005271296300_CIT0038","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jbmr.3631","article-title":"Reduction of cortical bone turnover and erosion depth after 2 and 3 years of denosumab: iliac bone histomorphometry in the FREEDOM trial","volume":"34","author":"Chavassieux","year":"2019","journal-title":"J Bone Miner Res."},{"issue":"3","key":"2022082005271296300_CIT0040","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jbmr.1482","article-title":"QCT measures of bone strength at the thoracic and lumbar spine: the Framingham study","volume":"27","author":"Samelson","year":"2012","journal-title":"J Bone Miner Res."},{"issue":"10","key":"2022082005271296300_CIT0041","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0021-9290(99)00099-8","article-title":"Femoral strength is better predicted by finite element models than QCT and DXA","volume":"32","author":"Cody","year":"1999","journal-title":"J Biomech."},{"issue":"1","key":"2022082005271296300_CIT0042","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1749-6632.2009.05348.x","article-title":"Biomechanical computed tomography\u2014noninvasive bone strength analysis using clinical computed tomography scans","volume":"1192","author":"Keaveny","year":"2010","journal-title":"Ann N Y Acad Sci."},{"issue":"10","key":"2022082005271296300_CIT0043","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1359\/jbmr.090416","article-title":"Improvements in vertebral body strength under teriparatide treatment assessed in vivo by finite element analysis: results from the EUROFORS study","volume":"24","author":"Graeff","year":"2009","journal-title":"J Bone Miner Res."},{"issue":"1","key":"2022082005271296300_CIT0044","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1359\/jbmr.061011","article-title":"Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of QCT scans in women with osteoporosis","volume":"22","author":"Keaveny","year":"2007","journal-title":"J Bone Miner Res."},{"issue":"6","key":"2022082005271296300_CIT0045","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1002\/jbmr.1870","article-title":"Comparative effects of teriparatide and risedronate in glucocorticoid-induced osteoporosis in men: 18-month results of the EuroGIOPs trial","volume":"28","author":"Gl\u00fcer","year":"2013","journal-title":"J Bone Miner Res."},{"key":"2022082005271296300_CIT0046","article-title":"An essential warning: editorial on vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial, its extension","author":"Leder","year":"2017","journal-title":"J Bone Miner Res."},{"key":"2022082005271296300_CIT0047","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bone.2017.03.006","article-title":"Importance of prompt antiresorptive therapy in postmenopausal women discontinuing teriparatide or denosumab: the Denosumab and Teriparatide Follow-up study (DATA-Follow-up)","volume":"98","author":"Leder","year":"2017","journal-title":"Bone."},{"issue":"5","key":"2022082005271296300_CIT0048","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00198-017-3919-1","article-title":"Observations following discontinuation of long-term denosumab therapy","volume":"28","author":"McClung","year":"2017","journal-title":"Osteoporos Int."},{"key":"2022082005271296300_CIT0049","doi-asserted-by":"crossref","DOI":"10.1007\/s00223-017-0288-x","article-title":"Bone loss after denosumab: only partial protection with zoledronate","author":"Reid","year":"2017","journal-title":"Calcif Tissue Int."},{"key":"2022082005271296300_CIT0050","article-title":"In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1","volume":"33(3):659-672","author":"Goetz","year":"2021","journal-title":"Osteoporos Int."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac232\/43589463\/dgac232.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/7\/e2690\/45485405\/dgac232.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/7\/e2690\/45485405\/dgac232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T05:27:51Z","timestamp":1660973271000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/7\/e2690\/6569192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,4,16]]},"published-print":{"date-parts":[[2022,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac232","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,4,16]]}}}