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                <jats:p>Assess whether oral glucose tolerance test (OGTT) measures could serve as FPIR alternatives in their ability to predict T1D in autoantibody positive (Aab+) subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>OGTT and IVGTT were performed within 30 days of each other. Eleven OGTT variables were evaluated for (1) correlation with FPIR and (2) T1D prediction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Type 1 Diabetes TrialNet \u201cOral Insulin for Prevention of Diabetes in Relatives at Risk for T1D\u201d (TN-07) and Diabetes Prevention Trial-Type 1 Diabetes (DPT-1) studies clinical sites.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>TN-07 (n\u2005=\u2005292; age 9.4\u2005\u00b1\u20056.1 years) and DPT-1 (n\u2005=\u2005194; age 15.1\u2005\u00b1\u200510.0 years) Aab\u2005+\u2005relatives of T1D individuals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>(1) Correlation coefficients of OGTT measures with FPIR and (2) T1D prediction at 2 years using area under receiver operating characteristic (ROCAUC) curves.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Index60 showed the strongest correlation in DPT-1 (r\u2005=\u2005-0.562) but was weaker in TN-07 (r\u2005=\u2005-0.378). C-peptide index consistently showed good correlation with FPIR across studies (TN-07, r\u2005=\u20050.583; DPT-1, r\u2005=\u20050.544; P\u2005&amp;lt;\u20050.0001). Index60 and C-peptide index had the highest ROCAUCs for T1D prediction (0.778 vs 0.717 in TN-07 and 0.763 vs 0.721 in DPT-1, respectively; P\u2005=\u2005NS), followed by FPIR (0.707 in TN-07; 0.628 in DPT-1).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>C-peptide index was the strongest measure to correlate with FPIR in both studies. Index60 and C-peptide index had the highest predictive accuracy for T1D and were comparable. OGTTs could be considered instead of IVGTTs for subject stratification in T1D prevention trials.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac285","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T13:25:26Z","timestamp":1651929926000},"page":"e3273-e3280","source":"Crossref","is-referenced-by-count":10,"title":["Oral Glucose Tolerance Test Measures of First-phase Insulin Response and Their Predictive Ability for Type 1 Diabetes"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7694-3265","authenticated-orcid":false,"given":"David A","family":"Baidal","sequence":"first","affiliation":[{"name":"Department of Medicine and the Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami , Miami, FL 33136 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Warnock","sequence":"additional","affiliation":[{"name":"Data Analysis & Research, Office of Data Management & Information Systems, West Virginia Department of Education , Charleston, WV 25305 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Late Development Statistics, Biostatistics and Research Decision Sciences, Merck Research Laboratories , Rahway, NJ 07065-4607 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Geyer","sequence":"additional","affiliation":[{"name":"Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic , Rochester, MN 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer B","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami , Miami, FL 33136 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Moran","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Minnesota , Minneapolis, MN 55454 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Sosenko","sequence":"additional","affiliation":[{"name":"Department of Medicine and the Diabetes Research Institute, Leonard Miller School of Medicine, University of Miami , Miami, FL 33136 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmella","family":"Evans-Molina","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Pediatrics and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine , Indianapolis, IN 46202 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"2022071417234654800_CIT0001","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/dmrr.198","article-title":"The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus","volume":"17","author":"Del Prato","year":"2001","journal-title":"Diabetes Metab Res Rev."},{"key":"2022071417234654800_CIT0002","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120877","article-title":"\u03b2 Cell dysfunction exists more than 5 years before type 1 diabetes diagnosis","volume":"3","author":"Evans-Molina","year":"2018","journal-title":"JCI Insight."},{"key":"2022071417234654800_CIT0003","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.2337\/db13-1314","article-title":"Following the fate of the failing \u03b2-cell: new insights from first-phase insulin responses","volume":"62","author":"Williams","year":"2013","journal-title":"Diabetes."},{"key":"2022071417234654800_CIT0004","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.2337\/db13-0656","article-title":"Acceleration of the loss of the first-phase insulin response during the progression to type 1 diabetes in diabetes prevention trial-type 1 participants","volume":"62","author":"Sosenko","year":"2013","journal-title":"Diabetes."},{"key":"2022071417234654800_CIT0005","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF00500379","article-title":"Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients","volume":"34","author":"Vardi","year":"1991","journal-title":"Diabetologia."},{"key":"2022071417234654800_CIT0006","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM198508223130801","article-title":"First-degree relatives of patients with type I diabetes mellitus. 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