{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:42:57Z","timestamp":1778154177975,"version":"3.51.4"},"reference-count":40,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Data is needed regarding the effect of SARS-CoV-19 infection on young people with established type 1 diabetes. Identifying the disease outcomes, short and long-term sequelae may help to establish an evidence-based prevention and education policy for sick days management and DKA prevention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aims to describe clinical manifestations of SARS-CoV-2 infection in children, adolescents, and young adults with established type 1 diabetes (T1D) and explore the effects of COVID-19 on glycemic control and disease course.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>An observational study was conducted at 3 pediatric diabetes clinics in Israel between mid-March 2020 and mid-March 2021. Included were young people with established T1D, age younger than 30 years, who tested positive for SARS-CoV-2 (quantitative real-time polymerase chain reaction). Data were collected from medical files, diabetes devices, and COVID-19 questionnaire. Outcome measures were analyzed by the presence\/absence of clinical symptoms (symptomatic\/asymptomatic) and by age group (pediatric, &amp;lt;\u200519 years\/young adults, 19-30 years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 132 patients, mean age 16.9\u2005\u00b1\u20055.3years, with COVID-19\u2013confirmed infection, 103 (78%) had related symptoms; the most common were headaches, fatigue, fever, and loss of sense of smell. All had a mild disease course, but 4 required hospitalization and 2 cases were directly related to COVID-19 infection (pleuropneumonia in a patient with immunodeficiency syndrome, 1 case of diabetic ketoacidosis). Logistic regression analysis showed that age (odds ratio [OR]\u2005=\u20051.11; 95% CI, 1.01-1.23; P\u2005=\u2005.033), elevated glucose levels (OR\u2005=\u20055.23; 95% CI, 1.12-24.41; P\u2005=\u2005.035), and comorbidities (OR\u2005=\u20058.21; 95% CI, 1.00-67.51; P\u2005=\u2005.050) were positively associated with symptomatic infection. Persistent symptoms occurred in 16.5% of the cohort over a median of 6.7 months; age (OR\u2005=\u20051.14; 95% CI, 1.01-1.29; P\u2005=\u2005.030) and elevated glucose levels (OR\u2005=\u20053.42; 95% CI, 1.12-10.40; P\u2005=\u2005.031) were positively associated with persistent symptoms. Usually, no change was reported in glucose levels (64%) except for a temporary deterioration in glycemic control during the short infection period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Young people with established T1D experience mild COVID-19 infection. Elevated glucose levels during COVID-19 infection and older age were associated with prolonged disease course.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac288","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T12:25:24Z","timestamp":1651926324000},"page":"e3264-e3272","source":"Crossref","is-referenced-by-count":12,"title":["Symptoms and Glycemic Control in Young People With Type 1 Diabetes Following SARS-CoV-2 Infection: An Observational Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3571-4938","authenticated-orcid":false,"given":"Revital","family":"Nimri","sequence":"first","affiliation":[{"name":"The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children\u2019s Medical Center of Israel , Petah Tikva 49202 , Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv, 69978 , 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