{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:15:08Z","timestamp":1789578908893,"version":"build-2803163510"},"reference-count":48,"publisher":"The Endocrine Society","issue":"12","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Well-differentiated, low-grade neuroendocrine tumors (NETs) are the most frequent tumor types of the small bowel. Despite their generally indolent growth patterns and grade, these tumors tend to metastasize; indeed, at presentation, approximately 50% show nodal metastases and 30% of patients have distant metastases, even though they potentially show long survival. Little is available in the literature concerning the optimal nodal yield in small-bowel resections, and the clinical significance of nodal metastases and lymph node ratio (LNR) at this site is still debated. The aim of this review, through a systematic literature search, is to explore and analyze data regarding nodal status, adequacy of lymphadenectomy, and LNR on the prognosis of small bowel NETs using defined end points (progression-free survival, recurrence-free survival, and overall survival). Some surgical series have demonstrated that extended regional mesenteric lymphadenectomy, together with primary tumor resection, is associated with improved patient survival, and LNR is proving a prognostically important parameter. The new feature of mesenteric tumor deposits (MTDs; neoplastic deposits found in the mesenteric perivisceral adipose tissue that are not LN associated) seems to be a better prognostic predictor in small-bowel NETs compared to nodal metastases, and this feature is explored and critiqued in this review. In particular, increasing number of tumor deposits is correlated with increased risk of disease-specific death, and MTDs seem to correlate with peritoneal carcinomatosis.<\/jats:p>","DOI":"10.1210\/clinem\/dgac326","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T20:00:54Z","timestamp":1654027254000},"page":"3209-3221","source":"Crossref","is-referenced-by-count":16,"title":["Prognostic Effect of Lymph Node Metastases and Mesenteric Deposits in Neuroendocrine Tumors of the Small Bowel"],"prefix":"10.1210","volume":"107","author":[{"given":"Federica","family":"Grillo","sequence":"first","affiliation":[{"name":"Anatomic Pathology Unit, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genova, 16132 , Italy"},{"name":"IRCCS Ospedale Policlinico San Martino , Genoa 16132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5957-3247","authenticated-orcid":false,"given":"Manuela","family":"Albertelli","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino , Genoa 16132 , Italy"},{"name":"Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DiMI), University of Genova , Genoa, 16132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasqualino","family":"Malandrino","sequence":"additional","affiliation":[{"name":"Endocrinology, Department of Clinical and Experimental Medicine, University of Catania and Garibaldi-Nesima Medical Center , Catania 95122 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dotto","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Internal Medicine and Medical Specialties (DiMI), University of Genova , Genoa, 16132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genoveffa","family":"Pizza","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II , Naples 80138 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cittadini","sequence":"additional","affiliation":[{"name":"Radiology Unit, IRCCS Ospedale Policlinico San Martino , Genoa 16132 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[{"name":"Endocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II , Naples 80138 , Italy"},{"name":"Health Education and Sustainable Development, Federico II University , Naples 80138 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antongiulio","family":"Faggiano","sequence":"additional","affiliation":[{"name":"Department di Clinical and Molecular Medicine, Sapienza University , Rome 00185 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"issue":"3","key":"2022112511300460600_CIT0001","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.ecl.2018.05.003","article-title":"The genesis of the neuroendocrine tumors concept: from Oberndorfer to 2018","volume":"47","author":"\u00d6berg","year":"2018","journal-title":"Endocrinol Metab Clin North Am."},{"key":"2022112511300460600_CIT0002","first-page":"16","volume-title":"Digestive System Tumors. 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