{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:12:22Z","timestamp":1793304742318,"version":"4.5.0"},"reference-count":30,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Swedish government","award":["ALFGBG-873321"],"award-info":[{"award-number":["ALFGBG-873321"]}]},{"name":"Pfizer AB"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Diabetes is a major risk factor for cardiovascular disease and death but its effect on outcomes in acromegaly is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This work aimed to study whether diabetes affects morbidity and mortality in patients with acromegaly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide (Sweden), observational, matched-cohort study was conducted. Patients diagnosed with acromegaly between 1987 and 2020 were identified in the Swedish National Patient Registry and those with concomitant type 2 diabetes in the National Diabetes Registry and Drug Registry. The risk of overall mortality, and cardiovascular mortality and morbidity were estimated using Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study included 254 patients with acromegaly and concomitant type 2 diabetes (ACRO-DM group) and 532 without diabetes (ACRO group). Mean (SD) age at baseline was 62.6 (11.4) and 60.0 (12.1) years (P\u2005=\u2005.004) and the mean (SD) duration of acromegaly was 6.8 (8.1) and 6.0 (6.2) years (P\u2005=\u2005.098) in the ACRO-DM and ACRO groups, respectively. Overall mean follow-up was 9.2 years. The unadjusted overall mortality rate per 1000 person-years was 35.1 (95% CI, 27.2-44.7) and 20.1 (95% CI, 16.5-24.3) in the respective groups. The hazard ratio (HR) for overall mortality adjusted for multiple confounders was 1.58 (95% CI, 1.12-2.23) in the ACRO-DM group compared with the ACRO group. Cardiovascular mortality (HR 2.11; 95% CI, 1.09-4.10) and morbidity (HR 1.49; 95% CI, 1.21-1.82) were also increased in the ACRO-DM group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presence of diabetes in patients with acromegaly was associated with increased overall mortality as well as increased cardiovascular mortality and morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac400","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T09:36:41Z","timestamp":1656754601000},"page":"2483-2492","source":"Crossref","is-referenced-by-count":48,"title":["Effect of Diabetes on Morbidity and Mortality in Patients With Acromegaly"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8993-2071","authenticated-orcid":false,"given":"Daniela","family":"Esposito","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , 41345 Gothenburg , Sweden"},{"name":"Department of Endocrinology, Sahlgrenska University Hospital , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S","family":"Olsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , 41345 Gothenburg , Sweden"},{"name":"Department of Endocrinology, Sahlgrenska University Hospital , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Franz\u00e9n","sequence":"additional","affiliation":[{"name":"Health Metrics Group, Sahlgrenska Academy, University of Gothenburg , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervete","family":"Miftaraj","sequence":"additional","affiliation":[{"name":"National Diabetes Register, Centre of Registers , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan","family":"N\u00e5tman","sequence":"additional","affiliation":[{"name":"National Diabetes Register, Centre of Registers , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soffia","family":"Gudbj\u00f6rnsdottir","sequence":"additional","affiliation":[{"name":"National Diabetes Register, Centre of Registers , 41345 Gothenburg , Sweden"},{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-8440","authenticated-orcid":false,"given":"Gudmundur","family":"Johannsson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , 41345 Gothenburg , Sweden"},{"name":"Department of Endocrinology, Sahlgrenska University Hospital , 41345 Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"issue":"24","key":"2022081816105913400_CIT0001","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMra062453","article-title":"Medical progress: acromegaly","volume":"355","author":"Melmed","year":"2006","journal-title":"N Engl J 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