{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:26:36Z","timestamp":1781051196691,"version":"3.54.1"},"reference-count":37,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"AstraZeneca K.K."},{"DOI":"10.13039\/501100013170","name":"Ono Pharmaceutical Co., Ltd","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013170","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>J-DISCOVER is a prospective observational cohort study aiming to understand the current management of patients with early-stage type 2 diabetes mellitus (T2DM) in Japan, enrolling patients initiating second-line treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The current analysis examined the change in treatment satisfaction during the study period and factors affecting this change among patients in J-DISCOVER.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used data from the J-DISCOVER study, in which 1798 patients with T2DM aged\u2005\u2265\u200520 years were enrolled from 142 sites across Japan. Treatment satisfaction was assessed using the Diabetes Treatment Satisfaction Questionnaire (DTSQ).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean DTSQ treatment satisfaction score increased from 25.9 points at baseline to 27.3 points at 6 months, which was maintained through 36 months. Among the baseline characteristics examined, higher baseline DTSQ treatment satisfaction scores (P\u2005&amp;lt;\u20050.0001), older age (\u2265 75 vs\u2005&amp;lt;\u200565 years, P\u2005=\u20050.0096), living alone (P\u2005=\u20050.0356), and type of facility (clinics vs hospitals, P\u2005=\u20050.0044) had a significantly negative impact on the changes in DTSQ treatment satisfaction scores. Improvement in mean glycated hemoglobin (HbA1c) from baseline (7.7%) to 36 months (7.1%) was associated with positive changes in the DTSQ treatment satisfaction score (P\u2005=\u20050.0003).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Changes in DTSQ treatment satisfaction scores were related to HbA1c improvement, suggesting that the management strategy was appropriately planned for each patient. The results also suggest that the availability of social support for patients with T2DM who are elderly or living alone may be an important factor affecting treatment satisfaction, adherence, and clinical outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac420","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T15:08:17Z","timestamp":1658329697000},"page":"2424-2432","source":"Crossref","is-referenced-by-count":5,"title":["Changes in Treatment Satisfaction Over 3 Years in Patients With Type 2 Diabetes After Initiating Second-line Treatment"],"prefix":"10.1210","volume":"107","author":[{"given":"Tomoya","family":"Mita","sequence":"first","affiliation":[{"name":"Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Katakami","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Diabetes Care Medicine, Graduate School of Medicine, Osaka University , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Ono Pharmaceutical Co., Ltd. , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitaka","family":"Wada","sequence":"additional","affiliation":[{"name":"AstraZeneca K.K. , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Akiyama","sequence":"additional","affiliation":[{"name":"AstraZeneca K.K. , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naru","family":"Morita","sequence":"additional","affiliation":[{"name":"AstraZeneca K.K. , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kidani","sequence":"additional","affiliation":[{"name":"AstraZeneca K.K. , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-4937","authenticated-orcid":false,"given":"Toshitaka","family":"Yajima","sequence":"additional","affiliation":[{"name":"AstraZeneca K.K. , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iichiro","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University , Osaka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5961-1816","authenticated-orcid":false,"given":"Hirotaka","family":"Watada","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, Juntendo University Graduate School of Medicine , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"2022081816090938400_CIT0001","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation.","year":"2021","edition":"7"},{"key":"2022081816090938400_CIT0002","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation.","year":"2021","edition":"10"},{"issue":"4","key":"2022081816090938400_CIT0003","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s13340-016-0297-4","article-title":"New glycemic targets for patients with diabetes from the Japan Diabetes Society","volume":"7","author":"Araki","year":"2016","journal-title":"Diabetol Int."},{"key":"2022081816090938400_CIT0004","first-page":"111","article-title":"Diabetes treatment satisfaction questionnaire: DTSQ.","volume-title":"Handbook of Psychology and Diabetes: A Guide to Psychological Measurement in Diabetes Research and Practice","author":"Bradley","year":"1994"},{"issue":"5","key":"2022081816090938400_CIT0005","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1464-5491.1994.tb00316.x","article-title":"Guidelines for encouraging psychological well-being: report of a Working Group of the World Health Organization Regional Office for Europe and International Diabetes Federation European Region St Vincent Declaration Action Programme for Diabetes","volume":"11","author":"Bradley","year":"1994","journal-title":"Diabet Med."},{"issue":"5","key":"2022081816090938400_CIT0006","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3390\/ijerph15050947","article-title":"Use of diabetes treatment satisfaction questionnaire in diabetes care: importance of patient-reported outcomes","volume":"15","author":"Saisho","year":"2018","journal-title":"Int J Environ Res Public Health."},{"issue":"7","key":"2022081816090938400_CIT0007","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1111\/j.1464-5491.2009.02752.x","article-title":"Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily","volume":"26","author":"Best","year":"2009","journal-title":"Diabet Med."},{"issue":"6","key":"2022081816090938400_CIT0008","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1185\/03007995.2011.570745","article-title":"A systematic review of adherence, treatment satisfaction and costs, in fixed-dose combination regimens in type 2 diabetes","volume":"27","author":"Hutchins","year":"2011","journal-title":"Curr Med Res Opin."},{"issue":"4","key":"2022081816090938400_CIT0009","doi-asserted-by":"crossref","first-page":"807","DOI":"10.2337\/dc10-1926","article-title":"Effect of intensive glycemic lowering on health-related quality of life in type 2 diabetes: ACCORD trial","volume":"34","author":"Anderson","year":"2011","journal-title":"Diabetes Care."},{"issue":"2","key":"2022081816090938400_CIT0010","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/fampra\/cmp007","article-title":"Treatment satisfaction of diabetic patients: what are the contributing factors?","volume":"26","author":"Biderman","year":"2009","journal-title":"Fam Pract."},{"issue":"7","key":"2022081816090938400_CIT0011","first-page":"809","article-title":"The Japanese version of the Diabetes Treatment Satisfaction Questionnaire (DTSQ): translation and clinical evaluation","volume":"192","author":"Ishii","year":"2000","journal-title":"J Clin Exp Med."},{"issue":"7","key":"2022081816090938400_CIT0012","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.jdiacomp.2017.03.011","article-title":"Towards an improved global understanding of treatment and outcomes in people with type 2 diabetes: rationale and methods of the DISCOVER observational study program","volume":"31","author":"Ji","year":"2017","journal-title":"J Diabetes Complications."},{"issue":"1","key":"2022081816090938400_CIT0013","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s13300-017-0351-7","article-title":"Rationale and design for the J-DISCOVER study: DISCOVERing the treatment reality of type 2 diabetes in a real-world setting in Japan\u2014a protocol","volume":"9","author":"Katakami","year":"2018","journal-title":"Diabetes Ther."},{"issue":"2","key":"2022081816090938400_CIT0014","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s13300-021-01192-x","article-title":"Three-year glycaemic control and management in patients with type 2 diabetes initiating second-line treatment in Japan: a prospective observational study, J-DISCOVER","volume":"13","author":"Takahara","year":"2022","journal-title":"Diabetes Ther."},{"issue":"7","key":"2022081816090938400_CIT0015","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s13300-020-00846-6","article-title":"Baseline characteristics of patients with type 2 diabetes initiating second-line treatment in Japan: findings from the J-DISCOVER study","volume":"11","author":"Katakami","year":"2020","journal-title":"Diabetes Ther."},{"issue":"8","key":"2022081816090938400_CIT0016","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"Von Elm","year":"2007","journal-title":"Ann Intern Med."},{"key":"2022081816090938400_CIT0017","article-title":"Changes in DTSQ treatment satisfaction over 3 years in patients with type 2 diabetes after initiating second-line treatment","author":"Mita"},{"issue":"6","key":"2022081816090938400_CIT0018","doi-asserted-by":"crossref","first-page":"e0179546","DOI":"10.1371\/journal.pone.0179546","article-title":"Long-term patterns of adherence to medication therapy among patients with type 2 diabetes mellitus in Denmark: the importance of initiation","volume":"12","author":"Jensen","year":"2017","journal-title":"PloS One."},{"issue":"3","key":"2022081816090938400_CIT0019","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s13300-018-0414-4","article-title":"Reproducibility and validity of a questionnaire measuring treatment burden on patients with type 2 diabetes: Diabetic Treatment Burden Questionnaire (DTBQ)","volume":"9","author":"Ishii","year":"2018","journal-title":"Diabetes Ther"},{"issue":"2","key":"2022081816090938400_CIT0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2337\/dc16-2655","article-title":"Predictors of quality of life and other patient-reported outcomes in the PANORAMA multinational study of people with type 2 diabetes","volume":"41","author":"Bradley","year":"2018","journal-title":"Diabetes Care."},{"issue":"9","key":"2022081816090938400_CIT0021","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.2337\/dc18-su09","article-title":"Updates to the standards of medical care in diabetes\u20142018","volume":"41","author":"Association American Diabetes","year":"2018","journal-title":"Diabetes Care."},{"issue":"10","key":"2022081816090938400_CIT0022","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1507\/endocrj.EJ18-0182","article-title":"Factors associated with treatment satisfaction in patients with type 2 diabetes mellitus using oral glucose-lowering agents: a cross-sectional study in urban districts in Japan","volume":"65","author":"Hayashi","year":"2018","journal-title":"Endocr J."},{"issue":"1","key":"2022081816090938400_CIT0023","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.numecd.2007.12.005","article-title":"Clinical and socio-economic correlates of quality of life and treatment satisfaction in patients with type 2 diabetes","volume":"19","author":"Nicolucci","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis."},{"issue":"9","key":"2022081816090938400_CIT0024","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1007\/s13300-021-01100-3","article-title":"Factors associated with treatment adherence and satisfaction in type 2 diabetes management in Japan: results from a web-based questionnaire survey","volume":"12","author":"Suzuki","year":"2021","journal-title":"Diabetes Ther."},{"issue":"7","key":"2022081816090938400_CIT0025","doi-asserted-by":"crossref","first-page":"e016180","DOI":"10.1136\/bmjopen-2017-016180","article-title":"What determines treatment satisfaction of patients with type 2 diabetes on insulin therapy? An observational study in eight European countries","volume":"7","author":"Boels","year":"2017","journal-title":"BMJ Open."},{"issue":"Suppl 1","key":"2022081816090938400_CIT0026","doi-asserted-by":"crossref","first-page":"S315","DOI":"10.1016\/j.dsx.2017.03.008","article-title":"Essential parameters and risk factors of the patients for diabetes care and treatment","volume":"11","author":"Bener","year":"2017","journal-title":"Diabetes Metab Syndr."},{"issue":"1","key":"2022081816090938400_CIT0027","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4093\/kdj.2010.34.1.55","article-title":"Factors that affect medication adherence in elderly patients with diabetes mellitus","volume":"34","author":"Park","year":"2010","journal-title":"Korean Diabetes J."},{"key":"2022081816090938400_CIT0028","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2147\/PPA.S24752","article-title":"A literature review to explore the link between treatment satisfaction and adherence, compliance, and persistence","volume":"6","author":"Barbosa","year":"2012","journal-title":"Patient Prefer Adherence."},{"key":"2022081816090938400_CIT0029","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2147\/PPA.S107543","article-title":"Associations between adherence and outcomes among older, type 2 diabetes patients: evidence from a Medicare supplemental database","volume":"10","author":"Boye","year":"2016","journal-title":"Patient Prefer Adherence."},{"issue":"5","key":"2022081816090938400_CIT0030","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1365-2702.2001.00520.x","article-title":"Adherence to self-care and social support","volume":"10","author":"Toljamo","year":"2001","journal-title":"J Clin Nurs."},{"issue":"5","key":"2022081816090938400_CIT0031","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/jdi.12333","article-title":"Impact of population aging on trends in diabetes prevalence: a meta-regression analysis of 160,000 Japanese adults","volume":"6","author":"Charvat","year":"2015","journal-title":"J Diabetes Investig."},{"key":"2022081816090938400_CIT0032","first-page":"1","article-title":"Population projections for Japan 2001-2050, with long-range population projections: 2051-2100","volume":"1","author":"Takahashi","year":"2003","journal-title":"J Popul Social Security (Popul)."},{"issue":"1","key":"2022081816090938400_CIT0033","first-page":"76","article-title":"Projection of the number of households in Japan (national estimate) for 2015-2040: estimates as of 2018","volume":"74","author":"Suzuki","year":"2018","journal-title":"Jinko Mondai Kenkyu [Journal of Population Problems]"},{"issue":"8","key":"2022081816090938400_CIT0034","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2337\/dc10-2424","article-title":"Correlates of quality of life in older adults with diabetes: the diabetes & aging study","volume":"34","author":"Laiteerapong","year":"2011","journal-title":"Diabetes Care."},{"issue":"5","key":"2022081816090938400_CIT0035","doi-asserted-by":"crossref","first-page":"819","DOI":"10.4103\/2230-8210.117219","article-title":"Hypoglycemia: the neglected complication","volume":"17","author":"Kalra","year":"2013","journal-title":"Indian J Endocrinol Metab."},{"issue":"3","key":"2022081816090938400_CIT0036","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/jdi.12790","article-title":"The current status of treatment-related severe hypoglycemia in Japanese patients with diabetes mellitus: a report from the committee on a survey of severe hypoglycemia in the Japan Diabetes Society","volume":"9","author":"Namba","year":"2018","journal-title":"J Diabetes Investig."},{"issue":"Suppl 3","key":"2022081816090938400_CIT0037","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1002\/dmrr.279","article-title":"Patient perceptions of diabetes and diabetes therapy: assessing quality of life","volume":"18","author":"Bradley","year":"2002","journal-title":"Diabetes Metab Res Rev."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac420\/45050864\/dgac420.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/9\/2424\/45476773\/dgac420.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/107\/9\/2424\/45476773\/dgac420.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T16:16:27Z","timestamp":1660839387000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/107\/9\/2424\/6647028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":37,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,7,20]]},"published-print":{"date-parts":[[2022,8,18]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac420","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,7,20]]}}}