{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:57:39Z","timestamp":1784836659111,"version":"3.55.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Department of Neuroscience"},{"name":"Rehabilitation"},{"name":"Ophthalmology"},{"name":"Genetics"},{"name":"Maternal and Child Health"},{"name":"University of Genova"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The etiology of central precocious puberty (CPP) includes a spectrum of conditions. Girls younger than age 6 years with CPP should undergo cranial magnetic resonance imaging (MRI), but it remains controversial whether all girls who develop CPP between the ages of 6 and 8 years require neuroimaging examination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the frequency of brain MRI abnormalities in girls diagnosed with CPP and the relationship between maternal factors, their age at presentation, clinical signs and symptoms, hormonal profiles, and neuroimaging findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were collected between January 2005 and September 2019 from 112 girls who showed clinical pubertal progression before 8 years of age who underwent brain MRI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MRI was normal in 47 (42%) idiopathic (I) scans, 54 (48%) patients had hypothalamic-pituitary anomalies (HPA) and\/or extra-HP anomalies (EHPA), and 11 (10%) had brain tumors or tumor-like conditions (BT\/TL), including 3 with neurological signs. Associated preexisting disorders were documented in 16. Girls with BT\/TL had a higher LH peak after GnRH test (P\u2005=\u20050.01) than I, and those older than age 6 years had a higher craniocaudal diameter of the pituitary gland (P\u2005=\u20050.01); their baseline FSH and LH (P\u2005=\u20050.004) and peak FSH (P\u2005=\u20050.01) and LH (P\u2005=\u20050.05) values were higher than I. Logistic regression showed maternal age at menarche (P\u2005=\u20050.02) and peak FSH (P\u2005=\u20050.02) as BT\/TL risk factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MRI provides valuable information in girls with CPP by demonstrating that fewer than half have a normal brain MRI and that few can have significant intracranial lesions after the age of 6, despite the absence of suggestive neurological signs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac422","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T20:28:56Z","timestamp":1658867336000},"page":"e4132-e4143","source":"Crossref","is-referenced-by-count":13,"title":["Clinical, Endocrine and Neuroimaging Findings in Girls With Central Precocious Puberty"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7243-2342","authenticated-orcid":false,"given":"Daniela","family":"Fava","sequence":"first","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2710-1798","authenticated-orcid":false,"given":"Andrea","family":"Calandrino","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-9299","authenticated-orcid":false,"given":"Maria Grazia","family":"Calevo","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Unit, Scientific Direction, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-049X","authenticated-orcid":false,"given":"Anna Elsa Maria","family":"Allegri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-6118","authenticated-orcid":false,"given":"Flavia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-1158","authenticated-orcid":false,"given":"Roberto","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6217-1919","authenticated-orcid":false,"given":"Giuseppa","family":"Patti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0754-4548","authenticated-orcid":false,"given":"Emilio","family":"Casalini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9166-1079","authenticated-orcid":false,"given":"Marta","family":"Bassi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8724-6721","authenticated-orcid":false,"given":"Andrea","family":"Accogli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , Italy"},{"name":"Department of Specialized Medicine, Division of Medical Genetics, McGill University Health Centre , Montreal H4A 3J1 , Canada"},{"name":"Department of Human Genetics, Faculty of Medicine, McGill University , Montreal H3A 1G1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6969-3250","authenticated-orcid":false,"given":"Abdel Razaq Ahmad A","family":"Alyasin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IRCCS Istituto Giannina Gaslini , Genoa 16147 , Italy"},{"name":"Department of Neuroscience, Rehabilitation, Ophtalmology, Genetics, Maternal and Child Health, University of Genoa , Genoa 16142 , 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