{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:05:21Z","timestamp":1792598721658,"version":"4.5.0"},"reference-count":18,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK121888"],"award-info":[{"award-number":["K23DK121888"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["#KL2 TR001879"],"award-info":[{"award-number":["#KL2 TR001879"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Urinary bladder paraganglioma (UBPGL) is rare.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to characterize the presentation and outcomes of patients diagnosed with UBPGL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a multicenter study of consecutive patients with pathologically confirmed UBPGL evaluated between 1971 and 2021. Outcomes included repeat bladder surgery, metastases, and disease-specific mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients (n=110 total; n=56 [51%] women) were diagnosed with UBPGL at a median age of 50 years (interquartile range [IQR], 36-61 years). Median tumor size was 2 cm (IQR, 1-4 cm). UBPGL was diagnosed prior to biopsy in only 37 (34%), and only 69 (63%) patients had evaluation for catecholamine excess. In addition to the initial bladder surgery, 26 (25%) required multiple therapies, including repeat surgery in 10 (9%). Synchronous metastases were present in 9 (8%) patients, and 24 (22%) other patients with UBPGL developed metachronous metastases at a median of 4 years (IQR, 2-10 years) after the initial diagnosis. Development of metachronous metastases was associated with younger age (hazard ratio [HR] 0.97; 95% CI, 0.94-0.99), UBPGL size (HR 1.69; 95% CI, 1.31-2.17), and a higher degree of catecholamine excess (HR 5.48; 95% CI, 1.40-21.39). Disease-specific mortality was higher in patients with synchronous metastases (HR 20.80; 95% CI, 1.30-332.91). Choice of initial surgery, genetic association, sex, or presence of muscular involvement on pathology were not associated with development of metastases or mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Only a minority of patients were diagnosed before biopsy\/surgery, reflecting need for better diagnostic strategies. All patients with UBPGL should have lifelong monitoring for development of recurrence and metastases.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac427","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T22:28:53Z","timestamp":1658874533000},"page":"2811-2821","source":"Crossref","is-referenced-by-count":30,"title":["Presentation, Management, and Outcomes of Urinary Bladder Paraganglioma: Results From a Multicenter Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8794-0318","authenticated-orcid":false,"given":"Kai","family":"Yu","sequence":"first","affiliation":[{"name":"Adrenal Center, Division of Endocrinology and Metabolism, West China Hospital, Sichuan University , Chengdu, Sichuan, 610041 , China"},{"name":"Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic , Rochester, MN, 55905 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-7824","authenticated-orcid":false,"given":"Andreas Ladefoged","family":"Ebbeh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , Aarhus, 8200 , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University , Aarhus, 8200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Obeid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan , Ann Arbor, MI, 48105 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Center for Adrenal Disorders, Brigham and Women\u2019s Hospital, Harvard Medical School , MA, 02115 , 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University , Copenhagen, 2100 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben","family":"S\u00f8ndergaard","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Aarhus University Hospital , Aarhus, 8200 , Denmark"},{"name":"Department of Clinical Medicine, Aarhus University , Aarhus, 8200 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Lehmann Christensen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Odense University Hospital , Odense, 5000 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christofer","family":"Juhlin","sequence":"additional","affiliation":[{"name":"Department of Oncology-Pathology, Karolinska Institute , Solna, 17164 , Sweden"},{"name":"Department of Pathology and Cancer Diagnostics, Karolinska University Hospital , Solna, 17176 , 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