{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:46:19Z","timestamp":1776743179718,"version":"3.51.2"},"reference-count":42,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["#31003A_166625"],"award-info":[{"award-number":["#31003A_166625"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_184708\/1"],"award-info":[{"award-number":["310030_184708\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["CRSII3_160741"],"award-info":[{"award-number":["CRSII3_160741"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bo & Kerstin Hjelt Diabetes Foundation and Fundaci\u00f3n Alfonso Mart\u00edn Escudero"},{"name":"Young Independent Investigator Grant"},{"name":"Novo Nordisk Programme for Diabetes Research in Europe 2020"},{"DOI":"10.13039\/501100006387","name":"Leenaards Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008494","name":"Vontobel Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005743","name":"Universit\u00e0 Cattolica del Sacro Cuore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005743","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Italian Ministry of Education"},{"name":"University and Research","award":["GR-2018-12365577"],"award-info":[{"award-number":["GR-2018-12365577"]}]},{"name":"University and Research","award":["RF-2019-12369293"],"award-info":[{"award-number":["RF-2019-12369293"]}]},{"name":"Italian Ministry of University and Research","award":["2020SH2ZZA"],"award-info":[{"award-number":["2020SH2ZZA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>During an asymptomatic prediabetic state, the functional \u00df-cell mass decreases to a critical threshold, triggering diabetes and related symptoms. To date, there are no reliable readouts able to capture in vivo a potential drop of the \u00df-cell mass.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Beside its use as a short-term marker of glycemic control, the deoxyhexose 1,5-anhydroglucitol was identified in rodents as a circulating biomarker of the functional \u00df-cell mass already in the asymptomatic prediabetic stage. The present study investigated the putative corresponding relevance of circulating 1,5-anhydroglucitol in different human cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analyzed clinical and blood parameters in patients with established type 2 diabetes and subjects considered at high risk of developing diabetes, as well as patients with no history of diabetes scheduled for pancreaticoduodenectomy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Circulating 1,5-anhydroglucitol was reduced in type 2 diabetic patients, negatively correlating with fasting plasma glucose (P\u2005&amp;lt;\u20050.0001) and hemoglobin A1c (P\u2005&amp;lt;\u20050.0001). In healthy subjects, 1,5-AG levels positively correlated with body mass index (P\u2005=\u20050.004) and Homeostatic Model Assessment of Insulin Resistance %S (P\u2005&amp;lt;\u20050.03) and was particularly high in nondiabetic obese individuals, potentially accounting for compensatory \u00df-cell expansion. Patients with no history of diabetes undergoing pancreaticoduodenectomy exhibited a 50% reduction of circulating 1,5-anhydroglucitol levels following surgery leading to an acute loss of their \u00df-cell mass (P\u2005=\u20050.002), regardless their glucose tolerance status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In summary, plasma concentration of 1,5-anhydroglucitol follows the \u00df-cell mass and its noninvasive monitoring may alert about the loss of \u00df cells in subjects at risk for diabetes, an event that cannot be captured by other clinical parameters of glycemic control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac444","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T15:48:38Z","timestamp":1658504918000},"page":"2833-2843","source":"Crossref","is-referenced-by-count":18,"title":["Circulating 1,5-Anhydroglucitol as a Biomarker of \u00df-cell Mass Independent of a Diabetes Phenotype in Human Subjects"],"prefix":"10.1210","volume":"107","author":[{"given":"Cecilia","family":"Jim\u00e9nez-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Faculty Diabetes Center, University of Geneva Medical Center , 1206 Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Mezza","sequence":"additional","affiliation":[{"name":"Pancreas Unit, CEMAD, Department of Internal medicine & Gastroenterology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS , Roma , Italy"},{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , 00168 Roma , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flore","family":"Sinturel","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Faculty Diabetes Center, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Department of Surgery, Geneva University Hospitals , 1211 Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Faculty Diabetes Center, University of Geneva Medical Center , 1206 Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Di Giuseppe","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , 00168 Roma , Italy"},{"name":"Endocrine and Metabolic Diseases Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS , 00168 Roma , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Quero","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , 00168 Roma , Italy"},{"name":"Pancreatic Surgery Unit, Department of Surgery, Gemelli Pancreatic Center, CRMPG (Advanced Pancreatic Research Center), Fondazione Policlinico Universitario A. Gemelli IRCCS , 00168 Roma , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois R","family":"Jornayvaz","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Faculty Diabetes Center, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Department of Medicine, Geneva University Hospitals , 1211 Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0491-6089","authenticated-orcid":false,"given":"Idris","family":"Guessous","sequence":"additional","affiliation":[{"name":"Department of Primary Care Medicine, Geneva University Hospitals , 1211 Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charna","family":"Dibner","sequence":"additional","affiliation":[{"name":"Department of Cell Physiology and Metabolism, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Faculty Diabetes Center, University of Geneva Medical Center , 1206 Geneva , Switzerland"},{"name":"Department of Surgery, Geneva University Hospitals , 1211 Geneva , Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-847X","authenticated-orcid":false,"given":"Patrick","family":"Schrauwen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences, Maastricht University Medical Center , 6200MD Maastricht , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Alfieri","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica del Sacro Cuore , 00168 Roma , Italy"},{"name":"Pancreatic Surgery Unit, Department of Surgery, Gemelli Pancreatic Center, CRMPG (Advanced Pancreatic Research Center), Fondazione Policlinico Universitario A. 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