{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:31:37Z","timestamp":1792801897995,"version":"4.5.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Torsten and Ragnar S\u00f6derberg\u2019s Foundations"},{"DOI":"10.13039\/100007793","name":"Kristian Gerhard Jebsen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical Scientist Training Program"},{"name":"Region Stockholm","id":[{"id":"https:\/\/ror.org\/02zrae794","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Kidney complications may be considerably higher in patients with chronic hypoparathyroidism (hypoPT) treated with activated vitamin D and calcium supplementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to investigate the risk of chronic kidney disease (CKD), urolithiasis, and hospitalization in patients with chronic hypoPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this population-based cohort study in Sweden, national registries (Swedish National Patient Register, Swedish Prescribed Drug Register, and Total Population Register, 1997\u20132018) were used to identify patients with chronic hypoPT and controls matched by sex, age, and county of residence. We determined time to CKD and urolithiasis diagnosis, and incidence rates of hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1562 patients with chronic hypoPT without preexisting CKD and 15\u2005620 controls were included. The risk of developing CKD was higher in patients with chronic hypoPT compared with controls (hazard ratio [HR] 4.45; 95% CI, 3.66-5.41). In people without prior urolithiasis (n\u2005=\u20051810 chronic hypoPT and n\u2005=\u200518\u2005100 controls), the risk of developing urolithiasis was higher in patients with chronic hypoPT (HR 3.55; 95% CI, 2.84-4.44) compared with controls. Patients with chronic hypoPT had higher incidence rates for all-cause hospitalization (49.59; 95% CI, 48.50-50.70, per 100 person-years vs 28.43; 95% CI, 28.15-28.71, respectively) and for CKD (3.46; 95% CI, 3.18-3.76, per 100 person-years vs 0.72; 95% CI, 0.68\u20130.77, respectively), compared with controls. Men with hypoPT appear to have a higher risk of CKD than women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with chronic hypoPT had an increased risk of CKD, urolithiasis, and hospitalization compared with controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac456","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T17:49:18Z","timestamp":1659203358000},"page":"e4098-e4105","source":"Crossref","is-referenced-by-count":16,"title":["Kidney Complications and Hospitalization in Patients With Chronic Hypoparathyroidism: A Cohort Study in Sweden"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-1567","authenticated-orcid":false,"given":"Oskar","family":"Swartling","sequence":"first","affiliation":[{"name":"Department of Medicine, Clinical Epidemiology Division, Karolinska Institutet , Stockholm 171 77 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-5795","authenticated-orcid":false,"given":"Marie","family":"Evans","sequence":"additional","affiliation":[{"name":"Renal unit, Department of Clinical Sciences, Interventions and Technology (CLINTEC), Karolinska Institutet and Karolinska University Hospital , Stockholm 141 52 , Sweden"},{"name":"Swedish Renal Registry, Department of Internal Medicine, Ryhov Regional Hospital , J\u00f6nk\u00f6ping 551 11 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Spelman","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Karolinska Institutet , Stockholm 171 77 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"Kamal","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm 171 76 , Sweden"},{"name":"Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital , Stockholm 171 76 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6091-9914","authenticated-orcid":false,"given":"Olle","family":"K\u00e4mpe","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital , Stockholm 171 76 , Sweden"},{"name":"Department of Medicine, Solna, Karolinska Institutet , Stockholm 171 76 , Sweden"},{"name":"K.G. Jebsen Center for Autoimmune Diseases, University of Bergen , Bergen 5021 , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mannstadt","sequence":"additional","affiliation":[{"name":"Endocrine Unit, Massachusetts General Hospital and Harvard Medical School , Boston, MA 02114 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6816-7577","authenticated-orcid":false,"given":"Ylva","family":"Trolle Lagerros","sequence":"additional","affiliation":[{"name":"Department of Medicine, Clinical Epidemiology Division, Karolinska Institutet , Stockholm 171 77 , Sweden"},{"name":"Center for Obesity, Academic Specialist Center, Stockholm Health Services , Stockholm 113 65 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigridur","family":"Bj\u00f6rnsdottir","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery, Karolinska Institutet , Stockholm 171 76 , Sweden"},{"name":"Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital , Stockholm 171 76 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,7,30]]},"reference":[{"issue":"4","key":"2022092808395040000_CIT0001","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1056\/NEJMcp0803050","article-title":"Clinical practice. 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