{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:15:58Z","timestamp":1791634558156,"version":"4.3.4"},"reference-count":30,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T00:00:00Z","timestamp":1659225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20ek0210105"],"award-info":[{"award-number":["JP20ek0210105"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007664","name":"Manpei Suzuki Diabetes Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007664","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Current guidelines recommend assessing glycemic control using continuous glucose monitoring (CGM) and hemoglobin A1c (HbA1c) measurement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to clarify the characteristics of patients who might benefit from CGM metrics in addition to HbA1c monitoring.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>CGM metrics, specifically time in range (TIR), time below range (TBR), and time above range (TAR), were determined in 999 outpatients with type 2 diabetes and compared between HbA1c categories (HbA1c\u2005&amp;lt;\u200553 mmol\/mol [7.0%, HbA1c\u2005&amp;lt;\u2005\u200a53], HbA1c 53-63 mmol\/mol [7.0-7.9%, HbA1c 53-63], HbA1c 64-74 mmol\/mol [8.0-8.9%, HbA1c 64-74], and HbA1c\u2005\u2265\u200575 mmol\/mol [9.0%, HbA1c\u2005\u2265\u2005\u200a75]) and between patients with identical HbA1c categories who were stratified by age, types of antidiabetic agents, and renal function.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For HbA1c\u2005&amp;lt;\u2005\u200a53 category, patients aged\u2005\u2265\u200565 years had a significantly higher nocturnal TBR than those aged\u2005&amp;lt;\u200565 years. For HbA1c\u2005&amp;lt;\u2005\u200a53 and HbA1c 53-63 categories, patients receiving insulin and\/or sulfonylureas had a significantly higher TAR and TBR, and a lower TIR than those not receiving these drugs, and for HbA1c 64-74 category, they had a significantly higher TBR. For HbA1c\u2005&amp;lt;\u2005\u200a53, HbA1c 53-63, and HbA1c 64-74 categories, patients with an estimated glomerular filtration rate (eGFR)\u2005&amp;lt;\u200560 mL\/min\/1.73 m2 had a significantly higher TBR during some periods than those with an eGFR\u2005\u2265\u200560.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher HbA1c levels do not always protect against hypoglycemic episodes. Our data demonstrate that using CGM metrics to complement HbA1c monitoring is beneficial, especially in older people, users of insulin and\/or sulfonylureas, and patients with chronic kidney disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac459","type":"journal-article","created":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T15:18:46Z","timestamp":1659280726000},"page":"e3990-e4003","source":"Crossref","is-referenced-by-count":11,"title":["The Importance of Continuous Glucose Monitoring-derived Metrics Beyond HbA1c for Optimal Individualized Glycemic Control"],"prefix":"10.1210","volume":"107","author":[{"given":"Hidenori","family":"Yoshii","sequence":"first","affiliation":[{"name":"Department of Medicine, Diabetology & Endocrinology, Juntendo Tokyo Koto Geriatric Medical Center , Koto-ku, Tokyo 136-0075 , 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