{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:15:44Z","timestamp":1791281744916,"version":"4.1.0"},"reference-count":53,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"NICHD","doi-asserted-by":"publisher","award":["K23HD092588"],"award-info":[{"award-number":["K23HD092588"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"NICHD","doi-asserted-by":"publisher","award":["R03HD102773"],"award-info":[{"award-number":["R03HD102773"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL151868"],"award-info":[{"award-number":["K23HL151868"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Doris Duke Foundation","award":["T325T32DK063687"],"award-info":[{"award-number":["T325T32DK063687"]}]},{"DOI":"10.13039\/100013845","name":"Pediatric Endocrine Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011013","name":"Society for Adolescent Health and Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Studies on cardiometabolic health in transgender and gender-diverse youth (TGDY) are limited to small cohorts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to determine the odds of cardiometabolic-related diagnoses in TGDY compared to matched controls in a cross-sectional analysis, using a large, multisite database (PEDSnet).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Electronic health record data (2009-2019) were used to determine odds of cardiometabolic-related outcomes based on diagnosis, anthropometric, and laboratory data using logistic regression among TGDY youth vs controls. The association of gender-affirming hormone therapy (GAHT) with these outcomes was examined separately among TGDY. TGDY (n\u2005=\u20054172) were extracted from 6 PEDSnet sites and propensity-score matched on 8 variables to controls (n\u2005=\u200516\u2005648). Main outcomes measures included odds of having cardiometabolic-related diagnoses among TGDY compared to matched controls, and among TGDY prescribed GAHT compared to those not prescribed GAHT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In adjusted analyses, TGDY had higher odds of overweight\/obesity (1.2; 95% CI, 1.1-1.3) than controls. TGDY with a testosterone prescription alone or in combination with a gonadotropin-releasing hormone agonist (GnRHa) had higher odds of dyslipidemia (1.7; 95% CI, 1.3-2.3 and 3.7; 95% CI, 2.1-6.7, respectively) and liver dysfunction (1.5; 95% CI, 1.1-1.9 and 2.5; 95% CI, 1.4-4.3) than TGDY not prescribed GAHT. TGDY with a testosterone prescription alone had higher odds of overweight\/obesity (1.8; 95% CI, 1.5-2.1) and hypertension (1.6 95% CI, 1.2-2.2) than those not prescribed testosterone. Estradiol and GnRHa alone were not associated with greater odds of cardiometabolic-related diagnoses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>TGDY have increased odds of overweight\/obesity compared to matched controls. Screening and tailored weight management, sensitive to the needs of TGDY, are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac469","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T01:59:30Z","timestamp":1660096770000},"page":"e4004-e4014","source":"Crossref","is-referenced-by-count":43,"title":["Multicenter Analysis of Cardiometabolic-related Diagnoses in Transgender and Gender-Diverse Youth: A PEDSnet Study"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-789X","authenticated-orcid":false,"given":"Anna","family":"Valentine","sequence":"first","affiliation":[{"name":"University of Colorado Anschutz Medical Campus, Department of Pediatrics , Aurora, Colorado 80045 , USA"},{"name":"Children\u2019s Hospital Colorado, Division of Endocrinology , Aurora, Colorado 80045 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