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Finland","doi-asserted-by":"crossref","award":["128576"],"award-info":[{"award-number":["128576"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005744","name":"Foundation for Pediatric Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005744","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely missing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to compare pubertal hormone levels between boys with a history of congenital cryptorchidism who experienced spontaneous testicular descent or underwent orchiopexy and boys without a history of cryptorchidism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a nested case-control study within a population-based birth cohort, with a prospective, longitudinal pubertal follow-up every 6 months (2005 to 2019). Participants were 109 Finnish boys, including boys with a history of unilateral cryptorchidism who underwent orchiopexy (n = 15), unilateral cryptorchidism who had spontaneous testicular descent (n = 15), bilateral cryptorchidism who underwent orchiopexy (n = 9), bilateral cryptorchidism who had spontaneous testicular descent (n = 7), and controls (n = 63). Serum reproductive hormone levels and testicular volumes were measured.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>From around onset of puberty, boys with bilateral cryptorchidism who underwent orchiopexy had significantly higher follicle-stimulating hormone (FSH) and lower inhibin B levels than controls. Boys with unilateral cryptorchidism who underwent orchiopexy had significantly higher FSH than controls, whereas inhibin B levels were similar. Testosterone, luteinizing hormone, insulin-like factor 3, and IGF-I were generally similar between groups. Testicular volume of boys with unilateral or bilateral cryptorchidism who underwent orchiopexy was smaller than that of the controls from 1 year after pubertal onset (P &amp;lt; 0.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Cryptorchid boys, particularly those with bilateral cryptorchidism who underwent orchiopexy, had altered levels of serum biomarkers of Sertoli cells and germ cells and smaller testicular volumes compared with controls.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac520","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T07:50:21Z","timestamp":1662623421000},"page":"3353-3361","source":"Crossref","is-referenced-by-count":10,"title":["Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism"],"prefix":"10.1210","volume":"107","author":[{"given":"Wiwat","family":"Rodprasert","sequence":"first","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, University of Turku , Turku 20520 , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko J","family":"Koskenniemi","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, University of Turku , Turku 20520 , Finland"},{"name":"Department of Pediatrics, Turku University Hospital , Turku 20520 , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena E","family":"Virtanen","sequence":"additional","affiliation":[{"name":"Research Centre for Integrative Physiology and Pharmacology and Centre for Population Health Research, Institute of Biomedicine, 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Research Centre, Turku University Hospital , Turku 20520 , Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2842-1128","authenticated-orcid":false,"given":"Jakob","family":"Albrethsen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Centre for Research and research training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Centre for Research and research training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0534-4350","authenticated-orcid":false,"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Centre for Research and research training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen DK-2100 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E","family":"Skakkebaek","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Centre for Research and research training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen DK-2100 , Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7259-1039","authenticated-orcid":false,"given":"Katharina M","family":"Main","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction, Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Centre for Research and research training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Copenhagen University Hospital\u2014Rigshospitalet , Copenhagen DK-2100 , Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen DK-2100 , 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