{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:00:58Z","timestamp":1793163658053,"version":"4.5.0"},"reference-count":27,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001922","name":"NIHR Efficacy and Mechanism Evaluation Programme","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001922","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,17]]},"abstract":"Abstract<\/jats:title>\n \n Context<\/jats:title>\n Thyroid peroxidase antibody (TPOAb) positivity is prevalent in women of reproductive age and predisposes to thyroid dysfunction, particularly hypothyroidism, which has adverse effects on pregnancy.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This study aimed to report the rate of development of abnormal thyroid function among initially euthyroid TPOAb-positive women recruited into the TABLET trial, to identify factors associated with the development of hypothyroidism, and to compare outcomes between euthyroid and treated hypothyroid individuals.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This observational cohort study, conducted at 49 UK hospitals between 2011 and 2016, included euthyroid TPOAb-positive women 16 to 40 years of age with a history of miscarriage or subfertility, planning pregnancy, randomized to levothyroxine 50\u2005mcg daily or placebo. Abnormal thyroid function, conception rate, and live birth rate (LBR) \u226534 weeks were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Among the women, 70\/940 (7.4%) developed subclinical (SCH) or overt (OH) hypothyroidism: 27\/470 taking levothyroxine and 43\/470 placebo (relative risk [RR] 0.63; 95% CI, 0.39-1.00; P = 0.05); 83% of cases emerged prepregnancy. Baseline median serum TSH concentrations and TPOAb titers were significantly higher in those who developed hypothyroidism vs those who did not (P &lt; 0.001). Treated SCH\/OH demonstrated a higher failure-to-conceive rate compared with euthyroid women (adjusted RR 2.02 [1.56-2.62]; P &lt; 0.001). The LBR \u2265 34 weeks was similar in the treated SCH\/OH and euthyroid groups (adjusted RR 1.09 [0.77-1.55]; P = 0.6).<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Approximately 7% of euthyroid TPOAb-positive women will develop hypothyroidism within 1 year preconception or in pregnancy. Conception rates are lower in women with treated SCH\/OH compared with euthyroid women, but LBR are comparable. Thyroid function in TPOAb-positive women should be monitored regularly, when trying to conceive, to ensure prompt diagnosis and appropriate treatment initiation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1210\/clinem\/dgac525","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T12:19:57Z","timestamp":1663157997000},"page":"124-134","source":"Crossref","is-referenced-by-count":29,"title":["Evaluating the Progression to Hypothyroidism in Preconception Euthyroid Thyroid Peroxidase Antibody\u2013Positive Women"],"prefix":"10.1210","volume":"108","author":[{"given":"Sofia","family":"Gill","sequence":"first","affiliation":[{"name":"College of Medical and Dental Sciences, University of Birmingham , Birmingham B15 2TT , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Versha","family":"Cheed","sequence":"additional","affiliation":[{"name":"Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham , Birmingham 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