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Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The plasma concentrations of angiotensin-converting enzyme 2 (pACE2) has been independently associated with cardiovascular diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Higher pACE2 concentrations may be found in patients with primary aldosteronism (PA) and might lead to increased cardiovascular events.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Using an inception observational cohort, we examined pACE2 among 168 incident patients with PA. The expression of ACE2, serine protease 2 (TMPRSS2), and metalloprotease 17 (ADAM17) were assessed in peripheral blood mononuclear cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Incident PA and essential hypertension (EH) patients had similarly elevated pACE2 (47.04 \u00b1 22.06 vs 46.73 \u00b1 21.06 ng\/mL; P = .937). Age was negatively (\u03b2\u2005=\u2005\u22122.15; P = .033) and higher serum potassium level (\u03b2\u2005=\u20052.29; P = .024) was positively correlated with higher pACE2 in PA patients. Clinical complete hypertension remission after adrenalectomy (Primary Aldosteronism Surgery Outcome criteria) was achieved in 36 (50%) of 72 surgically treated unilateral PA (uPA) patients. At follow-up, pACE2 decreased in surgically treated patients who had (P &amp;lt; .001) or had no (P = .006) hypertension remission, but the pACE2 attenuation was not statistically significant in uPA (P = .085) and bilateral PA (P = .409) administered with mineralocorticoid receptor antagonist (MRA). Persistently elevated pACE2 (&amp;gt;\u200523\u2005ng\/mL) after targeted treatments was related to all-cause mortality and cardiovascular events among PA patients (hazard ratio\u2005=\u20058.8; P = .04); with a mean follow-up of 3.29 years. TMPRSS2 messenger RNA (mRNA) expression was higher in uPA (P = .018) and EH (P = .038) patients than in normotensive controls; it was also decreased after adrenalectomy (P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PA and EH patients had elevated pACE2 and higher expression of TMPRSS2 mRNA compared to those of normotensive population. Persistently elevated pACE2 (&amp;gt;\u200523 ng\/mL) after targeted treatments was associated risk of mortality and incident cardiovascular events.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac539","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T11:57:17Z","timestamp":1663675037000},"page":"3242-3251","source":"Crossref","is-referenced-by-count":7,"title":["Circulating Plasma Concentrations of ACE2 in Primary Aldosteronism and Cardiovascular Outcomes"],"prefix":"10.1210","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7935-0991","authenticated-orcid":false,"given":"Vin-Cent","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University , Taipei 100 , 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Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, National Taiwan University Hospital and College of Medicine, National Taiwan University , Taipei 100 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Chu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Taiwan University Hospital and College of Medicine, National Taiwan University , Taipei 100 , Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Far Eastern Polyclinic of Far Eastern Medical Foundation , Taipei City , 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