{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:25:14Z","timestamp":1793053514470,"version":"4.5.0"},"reference-count":34,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T00:00:00Z","timestamp":1666224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"National Key Research and Development Program of China","award":["2021YFC2501600"],"award-info":[{"award-number":["2021YFC2501600"]}]},{"name":"National Key Research and Development Program of China","award":["2021YFC2501603"],"award-info":[{"award-number":["2021YFC2501603"]}]},{"name":"National Key Research and Development Program of China","award":["SQ2022YFC2500131"],"award-info":[{"award-number":["SQ2022YFC2500131"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81970689"],"award-info":[{"award-number":["81970689"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Glucocorticoids have potent effects on the central nervous system. However, while patients with Cushing syndrome frequently report impairments in cognitive function, studies investigating cognitive function in patients with autonomous cortisol secretion (ACS) in adrenal incidentalomas (AIs) are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the present study was to evaluate neurocognitive function in patients with ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively recruited 63 patients with AI, 36 patients with nonfunctional adrenal adenoma (NFA) (46.5 \u00b1 10.5 years), and 27 patients with ACS (48.6 \u00b1 9.1 years); these patients underwent a battery of validated neuropsychological tests. ACS was diagnosed when serum cortisol levels after a 1-mg dexamethasone suppression test (cortisol1 mg DST) \u2265 50 nmol\/L.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Patients with ACS had higher frequency of subjective memory complaints (40.7% vs 13.9%, P &amp;lt; 0.05) and higher proportion of mild cognitive impairment (22.2% vs 2.8%, P &amp;lt; 0.05) than patients with NFA. Furthermore, patients with ACS had worse performance on working memory and the visuospatial\/constructional domain than patients with NFA (all P &amp;lt; 0.05). Serum cortisol1 mg DST was negatively correlated with working memory and visuospatial\/constructional domains (r = \u22120.307 and \u22120.306, respectively, all P &amp;lt; 0.05). Performance on working memory and visuospatial\/constructional domains gradually deteriorated with increases in serum cortisol1 mg DST (all P values for trend &amp;lt; 0.05). Multivariate linear regression analysis showed that serum cortisol1 mg DST was a significant risk factor for impairment of working memory and visuospatial\/constructional domains (B = \u22120.006 and \u22120.043, respectively, all P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study is the first to report that ACS is accompanied by impaired cognitive function. Consequently, cognitive function assessment should be incorporated into the clinical evaluation of patients with ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number<\/jats:title>\n                    <jats:p>NCT05357456.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac603","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T05:25:09Z","timestamp":1666243509000},"page":"633-641","source":"Crossref","is-referenced-by-count":20,"title":["Impaired Cognitive Function in Patients With Autonomous Cortisol Secretion in Adrenal Incidentalomas"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6805-799X","authenticated-orcid":false,"given":"Meng-si","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Graduate School of Peking Union Medical College , Nanjing 210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-yang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases , Nanjing 210008 , China"},{"name":"Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital Affiliated to Nanjing University Medical School , Nanjing 210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases , Nanjing 210008 , China"},{"name":"Endocrine and Metabolic Disease Medical Center, Drum Tower Hospital Affiliated to 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210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University , Nanjing 210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-jie","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanjing Drum Tower Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Graduate School of Peking Union Medical College , Nanjing 210008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Branch of National Clinical Research Centre for Metabolic Diseases , Nanjing 210008 , China"},{"name":"Endocrine and Metabolic Disease Medical 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