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In the mineralocorticoid receptor antagonist (MRA)-treated patients, the relationship between the change in PWV after 1 year (\u0394PWV) and posttreatment renin activity was explored using the restricted cubic spline (RCS) method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 445 enrolled PA patients, 255 received adrenalectomy (group 1) and 190 received MRAs. In the RCS model, posttreatment plasma renin activity (PRA) 1.5 ng\/mL\/h was the best cutoff value. Therefore, we divided the MRA-treated patients into 2 groups: those with suppressed PRA (&amp;lt; 1.5 ng\/mL\/h, group 2), and those with unsuppressed PRA (\u2265 1.5 ng\/mL\/h, group 3). Only group 1 and group 3 patients had a statistically significant improvement in PWV after treatment (both P &amp;lt; .001), whereas no significant improvement was noted in group 2 after treatment (P = .151). In analysis of variance and post hoc analysis, group 2 had a significantly lower \u0394PWV than group 1 (P = .007) and group 3 (P = .031). Multivariable regression analysis of the MRA-treated PA patients identified log-transformed posttreatment PRA, age, and baseline PWV as independent factors correlated with \u0394PWV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reversal of arterial stiffness was found in PA patients receiving adrenalectomy and in medically treated PA patients with unsuppressed PRA.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgac649","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T07:29:03Z","timestamp":1667633343000},"page":"624-632","source":"Crossref","is-referenced-by-count":23,"title":["Implication of MR Activity in Posttreatment Arterial Stiffness Reversal in Patients With Primary Aldosteronism"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-6674","authenticated-orcid":false,"given":"Zheng-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin 640 , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University , Taipei 100 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Ting","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin 640 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"},{"name":"Department of Medicine, National Taiwan University Cancer Center , Taipei 106 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Hsuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital Jin-Shan Branch , New Taipei City 208 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Yao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Far Eastern Memorial Hospital , New Taipei City 220 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Ching","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wei","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Far Eastern Memorial Hospital , New Taipei City 220 , Taiwan"},{"name":"Department of Computer Science and Engineering, Yuan Ze University , Taoyuan City 320 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital , Taipei 112 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo-Meng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, National Taiwan University Hospital , Taipei 100 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff S","family":"Chueh","sequence":"additional","affiliation":[{"name":"Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei 100 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin-Cent","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital and National 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