{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:37:36Z","timestamp":1793637456228,"version":"4.5.1"},"reference-count":36,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"crossref","award":["2019\/15873-6"],"award-info":[{"award-number":["2019\/15873-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Primary aldosteronism (PA) screening relies on an elevated aldosterone to renin ratio with a minimum aldosterone level, which varies from 10 to 15 ng\/dL (277-415.5 pmol\/L) using immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate intra-individual coefficient of variation (CV) of aldosterone and aldosterone to direct renin concentration ratio (A\/DRC) and its impact on PA screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 671 aldosterone and DRC measurements were performed by the same chemiluminescence assays in a large cohort of 216 patients with confirmed PA and at least 2 screenings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median intra-individual CV of aldosterone and A\/DRC was 26.8% and 26.7%. Almost 40% of the patients had at least one aldosterone level &amp;lt;15 ng\/dL, 19.9% had at least 2 aldosterone levels &amp;lt;15 ng\/dL, and 16.2% had mean aldosterone levels &amp;lt;15 ng\/dL. A lower cutoff of 10 ng\/dL was associated with false negative rates for PA screening of 14.3% for a single aldosterone measurement, 4.6% for 2 aldosterone measurements, and only 2.3% for mean aldosterone levels. Considering the minimum aldosterone, true positive rate of aldosterone thresholds was 85.7% for 10 ng\/dL and 61.6% for 15 ng\/dL. An A\/DRC &amp;gt;2 ng\/dL\/\u00b5IU\/mL had a true positive rate for PA diagnosis of 94.4% and 98.4% when based on 1 or 2 assessments, respectively. CV of aldosterone and A\/DRC were not affected by sex, use of interfering antihypertensive medications, PA lateralization, hypokalemia, age, and number of hormone measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Aldosterone concentrations had a high CV in PA patients, which results in an elevated rate of false negatives in a single screening for PA. Therefore, PA screening should be based on at least 2 screenings with concomitant aldosterone and renin measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac679","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T13:12:53Z","timestamp":1669122773000},"page":"1143-1153","source":"Crossref","is-referenced-by-count":37,"title":["Intra-individual Variability of Serum Aldosterone and Implications for Primary Aldosteronism Screening"],"prefix":"10.1210","volume":"108","author":[{"given":"Ana Alice W","family":"Maciel","sequence":"first","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais C","family":"Freitas","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo F C","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janaina","family":"Petenuci","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia A P","family":"Vilela","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"},{"name":"Disciplina de Endocrinologia, Departamento de Cl\u00ednica M\u00e9dica, Faculdade de Medicina da Universidade Federal de Uberl\u00e2ndia , Uberl\u00e2ndia, Minas Gerais, 38400-902 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana P","family":"Brito","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana S","family":"Goldbaum","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Claudia N","family":"Zerbini","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe L","family":"Ledesma","sequence":"additional","affiliation":[{"name":"Departamento de Patologia, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Y","family":"Tanno","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Srougi","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L","family":"Chambo","sequence":"additional","affiliation":[{"name":"Divis\u00e3o de Urologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adelaide A","family":"Pereira","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando M A","family":"Coelho","sequence":"additional","affiliation":[{"name":"Instituto de Radiologia InRad, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline C B S","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Instituto de Radiologia InRad, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco C","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Instituto de Radiologia InRad, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Pilan","sequence":"additional","affiliation":[{"name":"Instituto de Radiologia InRad, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pio-Abreu","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o V","family":"Silveira","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Nove de Julho , S\u00e3o Paulo, 03155-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda M","family":"Consolim-Colombo","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Nove de Julho , S\u00e3o Paulo, 03155-000 , Brasil"},{"name":"Unidade de Hipertens\u00e3o, Disciplina de Nefrologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A","family":"Bortolotto","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade Nove de Julho , S\u00e3o Paulo, 03155-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Latronico","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-1915","authenticated-orcid":false,"given":"Maria Candida B V","family":"Fragoso","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"},{"name":"Divis\u00e3o de Oncologia End\u00f3crina, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 01246-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano F","family":"Drager","sequence":"additional","affiliation":[{"name":"Unidade de Hipertens\u00e3o, Instituto do Cora\u00e7\u00e3o (InCor), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-900 , Brasil"},{"name":"Faculdade de Medicina, Universidade Nove de Julho , S\u00e3o Paulo, 03155-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice B","family":"Mendonca","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-6148","authenticated-orcid":false,"given":"Madson Q","family":"Almeida","sequence":"additional","affiliation":[{"name":"Unidade de Adrenal, Laborat\u00f3rio de Horm\u00f4nios e Gen\u00e9tica Molecular LIM\/42, Servi\u00e7o de Endocrinologia e Metabologia, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 05403-000 , Brasil"},{"name":"Divis\u00e3o de Oncologia End\u00f3crina, Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo (ICESP), Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo, 01246-000 , Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"issue":"5","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1210\/jc.2015-4061","article-title":"The management of primary aldosteronism: case detection, diagnosis, and treatment: an Endocrine Society clinical practice guideline","volume":"101","author":"Funder","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1210\/jc.2003-031337","article-title":"Increased diagnosis of primary aldosteronism, including surgically correctable forms, in centers from five continents","volume":"89","author":"Mulatero","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"14","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1016\/j.jacc.2017.01.052","article-title":"Prevalence and clinical manifestations of primary aldosteronism encountered in primary care practice","volume":"69","author":"Monticone","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.coemr.2019.07.001","article-title":"The prevalence of primary aldosteronism and evolving approaches for treatment","volume":"8","author":"Yozamp","year":"2019","journal-title":"Curr Opin Endocr Metab Res"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1590\/2359-3997000000274","article-title":"Diagnosis and management of primary aldosteronism","volume":"61","author":"Vilela","year":"2017","journal-title":"Arch Endocrinol Metab"},{"issue":"11","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.jacc.2006.07.059","article-title":"A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients","volume":"48","author":"Rossi","year":"2006","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S2213-8587(17)30367-4","article-title":"Cardiometabolic outcomes and mortality in medically treated primary aldosteronism: a retrospective cohort study","volume":"6","author":"Hundemer","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S2213-8587(17)30319-4","article-title":"Cardiovascular events and target organ damage in primary aldosteronism compared with essential hypertension: a systematic review and meta-analysis","volume":"6","author":"Monticone","year":"2018","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10 Pt 1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0895-7061(02)02969-2","article-title":"High prevalence of primary aldosteronism using postcaptopril plasma aldosterone to renin ratio as a screening test among Italian hypertensives","volume":"15","author":"Rossi","year":"2002","journal-title":"Am J Hypertens"},{"issue":"1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.7326\/M20-1758","article-title":"Primary aldosteronism: at the tipping point","volume":"173","author":"Funder","year":"2020","journal-title":"Ann Intern Med"},{"issue":"12","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11906-020-01106-5","article-title":"What is the most common cause of secondary hypertension? An interdisciplinary discussion","volume":"22","author":"Almeida","year":"2020","journal-title":"Curr Hypertens Rep"},{"issue":"6","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1210\/er.2018-00139","article-title":"The expanding spectrum of primary aldosteronism: implications for diagnosis, pathogenesis, and treatment","volume":"39","author":"Vaidya","year":"2018","journal-title":"Endocr Rev"},{"issue":"6","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1586\/eem.12.65","article-title":"Primary aldosteronism: comparison between guidelines of the Japanese and the US Endocrine Society","volume":"7","author":"Nishikawa","year":"2012","journal-title":"Expert Rev Endocrinol Metab"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ando.2016.05.001","article-title":"SFE\/SFHTA\/AFCE primary aldosteronism consensus: Introduction and handbook","volume":"77","author":"Amar","year":"2016","journal-title":"Ann Endocrinol (Paris)"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"516","DOI":"10.36660\/abc.20201238","article-title":"Brazilian Guidelines of hypertension\u20142020","volume":"116","author":"Barroso","year":"2021","journal-title":"Arq Bras Cardiol"},{"issue":"9","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1515\/cclm-2015-1094","article-title":"Prospective validation of an automated chemiluminescence-based assay of renin and aldosterone for the work-up of arterial hypertension","volume":"54","author":"Rossi","year":"2016","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"10","DOI":"10.7326\/M20-0065","article-title":"Web exclusive. The unrecognized prevalence of primary aldosteronism","volume":"173","author":"Brown","year":"2020","journal-title":"Ann Intern Med"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/HYPERTENSIONAHA.120.16429","article-title":"Intraindividual variability of aldosterone concentrations in primary aldosteronism: implications for case detection","volume":"77","author":"Yozamp","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/EJE-18-0704","article-title":"Management of endocrine disease: the role of confirmatory tests in the diagnosis of primary aldosteronism","volume":"180","author":"Morera","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/HYPERTENSIONAHA.113.02097","article-title":"An expert consensus statement on use of adrenal vein sampling for the subtyping of primary aldosteronism","volume":"63","author":"Rossi","year":"2014","journal-title":"Hypertension"},{"issue":"8","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1210\/jc.2013-4146","article-title":"Accuracy of adrenal imaging and adrenal venous sampling in predicting surgical cure of primary aldosteronism","volume":"99","author":"Lim","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S2213-8587(17)30135-3","article-title":"Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort","volume":"5","author":"Williams","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"10","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1210\/jc.2019-00531","article-title":"KCNJ5 Somatic mutation is a predictor of hypertension remission after adrenalectomy for unilateral primary aldosteronism","volume":"104","author":"Vilela","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"issue":"33","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1093\/eurheartj\/ehy339","article-title":"2018 ESC\/ESH guidelines for the management of arterial hypertension","volume":"39","author":"Williams","year":"2018","journal-title":"Eur Heart J"},{"issue":"3 Suppl 3","key":"2023041309390388200_","first-page":"7","article-title":"7th Brazilian guideline of arterial hypertension: chapter 2\u2014diagnosis and classification","volume":"107","author":"Malachias","year":"2016","journal-title":"Arq Bras Cardiol"},{"issue":"5 Pt 2","key":"2023041309390388200_","first-page":"F871","article-title":"Temporal pattern of renin and aldosterone secretion in men: effects of sodium balance","volume":"262","author":"Vieweg","year":"1992","journal-title":"Am J Physiol"},{"issue":"1","key":"2023041309390388200_","first-page":"28","article-title":"Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism","volume":"80","author":"Siragy","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1210\/jc.2002-021476","article-title":"Variability in the renin\/aldosterone profile under random and standardized sampling conditions in primary aldosteronism","volume":"88","author":"Tanabe","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1097\/HJH.0000000000000748","article-title":"Normoaldosteronemic aldosterone-producing adenoma: immunochemical characterization and diagnostic implications","volume":"33","author":"Rossi","year":"2015","journal-title":"J Hypertens"},{"issue":"1","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/ajh\/hpaa151","article-title":"Variability of aldosterone measurements during adrenal venous sampling for primary aldosteronism","volume":"34","author":"Yozamp","year":"2021","journal-title":"Am J Hypertens"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"dgz150","DOI":"10.1210\/clinem\/dgz150","article-title":"Diagnosis of primary aldosteronism by seated saline suppression test-variability between immunoassay and HPLC-MS\/MS","volume":"105","author":"Thuzar","year":"2020","journal-title":"J Clin Endocrinol Metabol"},{"issue":"11","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1210\/jc.2018-01041","article-title":"Aldosterone LC-MS\/MS assay-specific threshold values in screening and confirmatory testing for primary aldosteronism","volume":"103","author":"Guo","year":"2018","journal-title":"J Clin Endocrinol Metabol"},{"issue":"5","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"e2027","DOI":"10.1210\/clinem\/dgab924","article-title":"The Saline infusion test for primary aldosteronism: implications of immunoassay inaccuracy","volume":"107","author":"Eisenhofer","year":"2022","journal-title":"J Clin Endocrinol Metabol"},{"issue":"3","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-0031-1295460","article-title":"Factors affecting the aldosterone\/renin ratio","volume":"44","author":"Stowasser","year":"2012","journal-title":"Horm Metab Res"},{"issue":"11","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1210\/jc.2016-1963","article-title":"Dietary sodium restriction increases the risk of misinterpreting mild cases of primary aldosteronism","volume":"101","author":"Baudrand","year":"2016","journal-title":"J Clin Endocrinol Metabol"},{"issue":"6","key":"2023041309390388200_","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1210\/jc.2010-2918","article-title":"Effect of contraceptives on aldosterone\/renin ratio may vary according to the components of contraceptive, renin assay method, and possibly route of administration","volume":"96","author":"Ahmed","year":"2011","journal-title":"J Clin Endocrinol Metabol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac679\/48828002\/dgac679.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/5\/1143\/49873811\/dgac679.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/5\/1143\/49873811\/dgac679.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T10:20:21Z","timestamp":1701426021000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/108\/5\/1143\/6840305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,22]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,11,22]]},"published-print":{"date-parts":[[2023,4,13]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac679","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,11,22]]}}}