{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:27:57Z","timestamp":1787239677854,"version":"build-2736575974"},"reference-count":41,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T00:00:00Z","timestamp":1669939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["MCT-154710"],"award-info":[{"award-number":["MCT-154710"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Resistance exercise training (strength training) and aerobic exercise training are both recommended for people with type 1 diabetes, but it is unknown whether adding resistance exercise provides incremental benefits in people with this condition who already perform aerobic exercise regularly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This work aimed to evaluate the incremental effect of resistance training on glycated hemoglobin A1c (HbA1c), fitness, body composition, and cardiometabolic risk factors in aerobically active people with type 1 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Resistance Exercise in Already-active Diabetic Individuals (READI) trial (NCT00410436) was a 4-center, randomized, parallel-group trial. After a 5-week run-in period with diabetes management optimization, 131 aerobically active individuals with type 1 diabetes were randomly assigned to resistance exercise (n = 71, intervention\u2014INT) or control (n = 60, CON) for 22 additional weeks. Both groups maintained their aerobic activities and were provided dietary counseling throughout. Exercise training was 3 times per week at community-based facilities. The primary outcome was HbA1c, and secondary outcomes included fitness (peak oxygen consumption, muscle strength), body composition (anthropometrics, dual-energy x-ray absorptiometry, computed tomography), and cardiometabolic risk markers (lipids, apolipoproteins). Assessors were blinded to group allocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in HbA1c change between INT and CON. Declines in HbA1c (INT: 7.75 \u00b1 0.10% [61.2 \u00b1 1.1 mmol\/mol] to 7.55 \u00b1 0.10% [59 \u00b1 1.1 mmol\/mol]; CON: 7.70 \u00b1 0.11% [60.7 \u00b1 1.2 mmol\/mol] to 7.57 \u00b1 0.11% [59.6 \u00b1 1.3 mmol\/mol]; intergroup difference in change \u22120.07 [95% CI, \u22120.31 to 0.18]). Waist circumference decreased more in INT than CON after 6 months (P = .02). Muscular strength increased more in INT than in CON (P &amp;lt; .001). There were no intergroup differences in hypoglycemia or any other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adding resistance training did not affect glycemia, but it increased strength and reduced waist circumference, in aerobically active individuals with type 1 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgac682","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T17:32:38Z","timestamp":1670002358000},"page":"e63-e75","source":"Crossref","is-referenced-by-count":5,"title":["The Resistance Exercise in Already Active Diabetic Individuals (READI) Randomized Clinical Trial"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-717X","authenticated-orcid":false,"given":"Ronald J","family":"Sigal","sequence":"first","affiliation":[{"name":"Departments of Medicine, Cardiac Sciences and Community Health Sciences, Cumming School of Medicine, University of Calgary , 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