{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:58:46Z","timestamp":1775311126375,"version":"3.50.1"},"reference-count":53,"publisher":"The Endocrine Society","issue":"5","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Guangzhou Municipal Science and Technology Project of China","award":["2012J4100035"],"award-info":[{"award-number":["2012J4100035"]}]},{"name":"Guangzhou Municipal Science and Technology Project of China","award":["201804010214"],"award-info":[{"award-number":["201804010214"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81100235"],"award-info":[{"award-number":["81100235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["S2011040004458"],"award-info":[{"award-number":["S2011040004458"]}]},{"name":"Science and Technology Planning Project of Guangdong Province, China","award":["2014A020212372"],"award-info":[{"award-number":["2014A020212372"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Refractory angina pectoris (RAP) is a specific subtype of coronary artery disease (CAD). Lipoprotein(a) [Lp(a)] and its induced coronary microvascular dysfunction (CMD) play an important role in pathogenesis of RAP, but its metabolism was mostly genetically determined. The adenosine triphosphate (ATP)-sensitive potassium channel (KATP) is involved in lipid metabolism and microvascular homeostasis and becomes a promising target for the management of Lp(a) and its related RAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate associations of KATP variants with hyperlipoprotein(a)emia, CMD, and RAP in patients with CAD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients, Settings<\/jats:title><jats:p>A total of 1148 newly diagnosed patients with CAD were prospectively selected and divided into control (Lp(a) &amp;lt; 180 mg\/dL) and case (Lp(a) \u2265 180 mg\/dL, hyperlipoprotein(a)emia) group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>9 KATP variants were genotyped by MassARRAY system. The expression profile of exosome-derived microRNAs (exo-miRs) was identified by next-generation sequencing, and the expression levels of differentially expressed exo-miRs were evaluated by quantitative RT-PCR in verification cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three KATP variants were associated with increased risk of hyperlipoprotein(a)emia in patients with CAD as follows: rs2285676 (AA + GA genotype, adjusted odds ratio [OR] = 1.44; 95% CI, 1.10-1.88; P = 0.008), rs1799858 (CC genotype, adjusted OR = 1.33; 95% CI, 1.03-1.73; P = 0.030), and rs141294036 (CC genotype, adjusted OR = 1.43; 95% CI, 1.10-1.87; P = 0.008). Only rs141294036 was associated with increased risk of CMD (CC genotype, adjusted OR = 1.62; 95% CI, 1.23-2.13; P = 0.001), and further with increased RAP risk (CC genotype, adjusted hazard ratio = 2.05; 95% CI, 1.22-3.43; P = 0.007) after median follow-up of 50.6 months. Between the 2 genotypes of rs141294036, 152 exo-miRs were significantly differentially expressed, but only 10 exo-miRs (miR-7110-3p, miR-548az-5p, miR-214-3p, let-7i-5p, miR-218-5p, miR-128-3p, miR-378i, miR-625-3p, miR-128-1-5p, and miR-3187-3p) were further confirmed in patients with RAP with hyperlipoprotein(a)emia and CMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>KATP rs141294036 may serve a potential genetic marker for hyperlipoprotein(a)emia, CMD, and RAP in patients with CAD.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgac709","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T20:30:14Z","timestamp":1670272214000},"page":"1061-1074","source":"Crossref","is-referenced-by-count":7,"title":["Association of KATP Variants With CMD and RAP in CAD Patients With Increased Serum Lipoprotein(a) Levels"],"prefix":"10.1210","volume":"108","author":[{"given":"Jingxian","family":"Pei","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Guangzhou Medical University , Guangzhou 510260 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0508-0129","authenticated-orcid":false,"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology , Guangzhou 510180 , China"},{"name":"Department of Cardiology, Guangzhou First People's Hospital, Guangzhou Medical University , Guangzhou 510180 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Electronic Business, School of Economics and Finance, South China University of Technology , Guangzhou 510006 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxian","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology , Guangzhou 510180 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology , Guangzhou 510180 , China"},{"name":"Department of Cardiology, The Second Affiliated Hospital, School of Medicine, South China University of Technology , Guangzhou 510180 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianwang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology , Guangzhou 510180 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Guangzhou First People's Hospital, South China University of Technology , Guangzhou 510180 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"issue":"14","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1161\/CIRCULATIONAHA.118.031373","article-title":"Reappraisal of ischemic heart disease","volume":"138","author":"Kaski","year":"2018","journal-title":"Circulation"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5339\/gcsp.2015.28","article-title":"High prevalence of raised lipoprotein(a) in patients with refractory angina","volume":"2015","author":"Khan","year":"2015","journal-title":"Glob Cardiol Sci Pract"},{"issue":"20","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/eurheartj\/ehx178","article-title":"Apheresis as novel treatment for refractory angina with raised lipoprotein(a): a randomized controlled cross-over trial","volume":"38","author":"Khan","year":"2017","journal-title":"Eur Heart J"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jcin.2019.12.001","article-title":"Treating coronary microvascular dysfunction as the \u201cculprit\u201d lesion in patients with refractory angina: lessons from CorMicA at 1 year","volume":"13","author":"Taqueti","year":"2020","journal-title":"JACC Cardiovasc Interv"},{"issue":"5","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/dme.12862","article-title":"Lipoprotein(a) predicts a new onset of chronic kidney disease in people with type 2 diabetes mellitus","volume":"33","author":"Yun","year":"2016","journal-title":"Diabet Med"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jacl.2015.12.030","article-title":"Lipoprotein(a) predicts the development of diabetic retinopathy in people with type 2 diabetes mellitus","volume":"10","author":"Yun","year":"2016","journal-title":"J Clin Lipidol"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1744-9987.2009.00667.x","article-title":"Single lipoprotein apheresis session improves cardiac microvascular function in patients with elevated lipoprotein(a): detection by stress\/rest perfusion magnetic resonance imaging","volume":"13","author":"Bohl","year":"2009","journal-title":"Ther Apher Dial"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5339\/gcsp.2014.3","article-title":"The expanding role of lipoprotein apheresis in the treatment of raised lipoprotein(a) in ischaemic heart disease and refractory angina","volume":"2014","author":"Khan","year":"2014","journal-title":"Glob Cardiol Sci Pract"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1161\/ATV.0000000000000147","article-title":"Lipoprotein(a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart Association","volume":"42","author":"Reyes-Soffer","year":"2022","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"816847","DOI":"10.3389\/fcvm.2022.816847","article-title":"Associations of ATP-sensitive potassium channel's Gene polymorphisms with type 2 diabetes and related cardiovascular phenotypes","volume":"9","author":"Liu","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"8","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1089\/gtmb.2011.0337","article-title":"ABCC8 polymorphisms are associated with triglyceride concentration in type 2 diabetics on sulfonylurea therapy","volume":"16","author":"Nikolac","year":"2012","journal-title":"Genet Test Mol Biomarkers"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12881-018-0601-1","article-title":"Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population","volume":"19","author":"Engwa","year":"2018","journal-title":"BMC Med Genet"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/1753-0407.12565","article-title":"Prediabetes is associated with genetic variations in the gene encoding the Kir6.2 subunit of the pancreatic ATP-sensitive potassium channel (KCNJ11): a case-control study in a Han Chinese youth population","volume":"10","author":"Xu","year":"2018","journal-title":"J Diabetes"},{"issue":"4","key":"2023041309390406900_","first-page":"589","article-title":"Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina","volume":"18","author":"Tomita","year":"2006","journal-title":"Int J Mol Med"},{"issue":"4","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1016\/j.ijcard.2013.04.210","article-title":"Coronary spasm and acute myocardial infarction due to a mutation (V734I) in the nucleotide binding domain 1 of ABCC9","volume":"168","author":"Smith","year":"2013","journal-title":"Int J Cardiol"},{"issue":"5","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2007-967086","article-title":"The common C49620T polymorphism in the sulfonylurea receptor gene (ABCC8), pancreatic beta cell function and long-term diabetic complications in obese patients with long-lasting type 2 diabetes mellitus","volume":"115","author":"Stefanski","year":"2007","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"13","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1177\/2047487320926780","article-title":"Susceptibility to ischaemic heart disease: focusing on genetic variants for ATP-sensitive potassium channel beyond traditional risk factors","volume":"28","author":"Severino","year":"2020","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur Heart J"},{"key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"e00218","DOI":"10.1016\/j.plabm.2021.e00218","article-title":"Performance evaluation of five lipoprotein(a) immunoassays on the Roche Cobas c501 chemistry analyzer","volume":"25","author":"Wyness","year":"2021","journal-title":"Pract Lab Med"},{"key":"2023041309390406900_","author":"Pei","year":"2022"},{"issue":"9","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1177\/00033197211004390","article-title":"Slow coronary flow: pathophysiology, clinical implications, and therapeutic management","volume":"72","author":"Chalikias","year":"2021","journal-title":"Angiology"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1186\/s12967-020-02639-8","article-title":"Plasma exosome-derived microRNAs expression profiling and bioinformatics analysis under cross-talk between increased low-density lipoprotein cholesterol level and ATP-sensitive potassium channels variant rs1799858","volume":"18","author":"Liu","year":"2020","journal-title":"J Transl Med"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12944-020-01315-6","article-title":"ATP-sensitive potassium channels gene polymorphism rs1799858 affects the risk of macro-\/micro-vascular arteriosclerotic event in patients with increased low-density lipoprotein cholesterol levels","volume":"19","author":"Liu","year":"2020","journal-title":"Lipids Health Dis"},{"issue":"10","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1007\/s12031-020-01761-y","article-title":"Association of KATP gene polymorphisms with dyslipidemia and ischemic stroke risks among hypertensive patients in South China","volume":"71","author":"Liu","year":"2021","journal-title":"J Mol Neurosci"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00439-003-0943-3","article-title":"ABCA1 Gene polymorphisms and their associations with coronary artery disease and plasma lipids in males from three ethnic populations in Singapore","volume":"113","author":"Tan","year":"2003","journal-title":"Hum Genet"},{"key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"3491764","DOI":"10.1155\/2020\/3491764","article-title":"Lipoprotein(a) the insurgent: a new insight into the structure, function, metabolism, pathogenicity, and medications affecting lipoprotein(a) molecule","volume":"2020","author":"Jawi","year":"2020","journal-title":"J Lipids"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s12276-021-00560-8","article-title":"The aftermath of the interplay between the endoplasmic reticulum stress response and redox signaling","volume":"53","author":"Bhattarai","year":"2021","journal-title":"Exp Mol Med"},{"key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.expneurol.2018.10.005","article-title":"Astrocyte-specific deletion of Kir6.1\/K-ATP channel aggravates cerebral ischemia\/reperfusion injury through endoplasmic reticulum stress in mice","volume":"311","author":"Zhong","year":"2019","journal-title":"Exp Neurol"},{"key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"110547","DOI":"10.1016\/j.mce.2019.110547","article-title":"Endoplasmic reticulum quality control in lipoprotein metabolism","volume":"498","author":"Koerner","year":"2019","journal-title":"Mol Cell Endocrinol"},{"issue":"8","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1093\/hmg\/10.8.815","article-title":"Single nucleotide polymorphisms in exons of the apo(a) kringles IV types 6 to 10 domain affect lp(a) plasma concentrations and have different patterns in Africans and Caucasians","volume":"10","author":"Ogorelkova","year":"2001","journal-title":"Hum Mol Genet"},{"issue":"11","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1002\/2211-5463.12740","article-title":"Endoplasmic reticulum quality control of LDLR variants associated with familial hypercholesterolemia","volume":"9","author":"Kizhakkedath","year":"2019","journal-title":"FEBS open bio"},{"issue":"7","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1056\/NEJMcibr1913825","article-title":"Unfolding discoveries in heart failure","volume":"382","author":"Paulus","year":"2020","journal-title":"N Engl J Med"},{"issue":"6","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00395-013-0387-4","article-title":"Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease","volume":"108","author":"Fedele","year":"2013","journal-title":"Basic Res Cardiol"},{"issue":"11","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1161\/STROKEAHA.120.030063","article-title":"Microvascular brain disease progression and risk of stroke: the ARIC study","volume":"51","author":"Koton","year":"2020","journal-title":"Stroke"},{"issue":"10","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1001\/jamacardio.2021.1832","article-title":"Coronary microvascular dysfunction in heart failure with preserved ejection fraction-common, unrecognized, and prevalent in patients with or without epicardial CAD","volume":"6","author":"Taqueti","year":"2021","journal-title":"JAMA Cardiol"},{"issue":"2","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/08860220802595948","article-title":"Microalbuminuria\u2013a biomarker of renal microvascular disease","volume":"31","author":"Futrakul","year":"2009","journal-title":"Ren Fail"},{"issue":"1","key":"2023041309390406900_","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-014-0075-3","article-title":"An analysis of the association between a polymorphism of KCNJ11 and diabetic retinopathy in a Chinese Han population","volume":"20","author":"Liu","year":"2015","journal-title":"Eur J Med Res"},{"issue":"4","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"355","DOI":"10.5603\/CJ.2012.0065","article-title":"Increased mean platelet volume associated with extent of slow coronary flow","volume":"19","author":"Isik","year":"2012","journal-title":"Cardiol J"},{"issue":"11","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.3980","article-title":"Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis","volume":"21","author":"Wagschal","year":"2015","journal-title":"Nat Med"},{"issue":"6","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"8177","DOI":"10.18632\/aging.202628","article-title":"Genetic predisposition and bioinformatics analysis of ATP-sensitive potassium channels polymorphisms with the risks of elevated apolipoprotein B serum levels and its related arteriosclerosis cardiovascular disease","volume":"13","author":"Liu","year":"2021","journal-title":"Aging"},{"issue":"3","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cbin.10896","article-title":"miR-23b-3p and miR-125b-5p downregulate apo(a) expression by targeting Ets1 in HepG2 cells","volume":"42","author":"Zeng","year":"2018","journal-title":"Cell Biol Int"},{"issue":"3","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/db20-0181","article-title":"Activation of dsRNA-dependent protein kinase R by miR-378 sustains metabolic inflammation in hepatic insulin resistance","volume":"70","author":"Wang","year":"2021","journal-title":"Diabetes"},{"issue":"4","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/WNR.0000000000001751","article-title":"Circular noncoding RNA circ_0007865, serves as a competing endogenous RNA, targeting the miR-214-3p\/FKBP5 axis to regulate oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells","volume":"33","author":"Liu","year":"2022","journal-title":"Neuroreport"},{"issue":"3","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s12265-022-10266-5","article-title":"The peripheral circulating exosomal microRNAs related to central inflammation in chronic heart failure","volume":"15","author":"Xiao","year":"2022","journal-title":"J Cardiovasc Transl Res"},{"issue":"B","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"108299","DOI":"10.1016\/j.intimp.2021.108299","article-title":"Inhibition of miR-218-5p reduces myocardial ischemia-reperfusion injury in a Sprague-Dawley rat model by reducing oxidative stress and inflammation through MEF2C\/NF-kappaB pathway","volume":"101","author":"Yang","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"9919729","DOI":"10.1155\/2021\/9919729","article-title":"Inhibition of miR-214-3p protects endothelial cells from ox-LDL-induced damage by targeting GPX4","volume":"2021","author":"Xie","year":"2021","journal-title":"Biomed Res Int"},{"issue":"12","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1161\/CIRCRESAHA.120.316489","article-title":"miR-128-3p is a novel regulator of vascular smooth muscle cell phenotypic switch and vascular diseases","volume":"126","author":"Farina","year":"2020","journal-title":"Circ Res"},{"issue":"5","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.3390\/ijms19051467","article-title":"Circulating microRNAs in young patients with acute coronary syndrome","volume":"19","author":"Tong","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2023041309390406900_","first-page":"4657","article-title":"Expression of miRNA-214 in the sera of elderly patients with acute myocardial infarction and its effect on cardiomyocyte apoptosis","volume":"17","author":"Yin","year":"2019","journal-title":"Exp Ther Med"},{"issue":"11","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s10072-017-3071-x","article-title":"Circulating pro-angiogenic and anti-angiogenic microRNA expressions in patients with acute ischemic stroke and their association with disease severity","volume":"38","author":"Jin","year":"2017","journal-title":"Neurol Sci"},{"issue":"5","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.yjmcc.2011.07.011","article-title":"Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome","volume":"51","author":"Widera","year":"2011","journal-title":"J Mol Cell Cardiol"},{"issue":"31","key":"2023041309390406900_","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/eurheartj\/ehu151","article-title":"Assessment of microRNAs in patients with unstable angina pectoris","volume":"35","author":"Zeller","year":"2014","journal-title":"Eur Heart J"},{"issue":"5","key":"2023041309390406900_","first-page":"3530","article-title":"miRNA-214 suppresses oxidative stress in diabetic nephropathy via the ROS\/Akt\/mTOR signaling pathway and uncoupling protein 2","volume":"17","author":"Yang","year":"2019","journal-title":"Exp Ther Med"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac709\/48582470\/dgac709.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/5\/1061\/49873807\/dgac709.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/5\/1061\/49873807\/dgac709.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,2]],"date-time":"2023-12-02T14:33:08Z","timestamp":1701527588000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/108\/5\/1061\/6873933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,12,5]]},"published-print":{"date-parts":[[2023,4,13]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac709","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,12,5]]}}}