{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:42:44Z","timestamp":1793194964329,"version":"4.5.0"},"reference-count":57,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T00:00:00Z","timestamp":1671580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700604"],"award-info":[{"award-number":["2021YFC2700604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"General Program of National Natural Science Foundation of China","award":["82171648"],"award-info":[{"award-number":["82171648"]}]},{"name":"Taishan Scholars Program for Young Experts of Shandong Province","award":["tsqn201812154"],"award-info":[{"award-number":["tsqn201812154"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Some studies have reported the early miscarriage rate is higher in polycystic ovary syndrome (PCOS) women. However, there is a lack of evidence as to whether the risk of embryo abnormalities increases in PCOS women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to evaluate the association between PCOS and embryo ploidy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A secondary analysis of a multicenter, randomized controlled trial was conducted from July 2017 to June 2018. The original intent was to identify whether preimplantation genetic test for aneuploidy (PGT-A) improves the live birth rate as compared with in vitro fertilization (IVF). From 14 reproductive centers, 190 patients diagnosed with PCOS and 1:1 age-matched non-PCOS patients were chosen from a PGT-A group. A total of 380 patients with 1118 embryos were included in our study. Intervention included women diagnosed with PCOS, and the main outcome measures were embryonic aneuploidy and embryonic mosaic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After adjusting for potential confounders, the rate of embryonic aneuploidy and embryonic mosaic in the PCOS group were comparable with the control group (embryonic aneuploid rate PCOS group: 14.0% vs control group: 18.3%, adjusted OR [95% CI]: 0.78 [0.54, 1.12]; P = .19; embryonic mosaic rate 10.9% vs 10.1%, adjusted OR [95% CI]: 0.91 [0.59, 1.40]; P = .66). We further stratified PCOS women into 4 groups according to phenotype. The rate of aneuploid and mosaic embryos was comparable between each PCOS phenotype and control group. There was still no significant difference of embryonic aneuploid and embryo mosaic rates among the 4 phenotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The risk of aneuploid and mosaic embryos did not increase in PCOS women. Thus, we suggest that the miscarriage rate arising from abnormal embryonic chromosomes could be similar between PCOS and non-PCOS women.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac726","type":"journal-article","created":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T10:15:55Z","timestamp":1671704155000},"page":"e249-e257","source":"Crossref","is-referenced-by-count":9,"title":["Does the Risk of Embryo Abnormality Increase in PCOS Women? A Secondary Analysis of a Multicenter, Randomized Controlled Trial"],"prefix":"10.1210","volume":"108","author":[{"given":"Jiahui","family":"Wang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Song","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxiang","family":"Ni","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-6631","authenticated-orcid":false,"given":"Zi-Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai 200135 , China"},{"name":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai 200135 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7110-8698","authenticated-orcid":false,"given":"Junhao","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Shandong University , Jinan 250012, Shandong , China"},{"name":"Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University , Jinan 250012, Shandong , China"},{"name":"Shandong Key Laboratory of Reproductive Medicine , Jinan 250012, Shandong , China"},{"name":"Shandong Provincial Clinical Research Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"Shandong Technology Innovation Center for Reproductive Health , Jinan 250012, Shandong , China"},{"name":"National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University , Jinan 250012, Shandong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,12,21]]},"reference":[{"issue":"12","key":"2023051701090810100_dgac726-B1","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"issue":"6","key":"2023051701090810100_dgac726-B2","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/humrep\/deab069","article-title":"Use 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