{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:25:30Z","timestamp":1788809130997,"version":"build-2803163510"},"reference-count":8,"publisher":"The Endocrine Society","issue":"4","license":[{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,10]]},"DOI":"10.1210\/clinem\/dgac727","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T23:20:21Z","timestamp":1671146421000},"page":"e50-e51","source":"Crossref","is-referenced-by-count":2,"title":["Isolated Hypogonadotropic Hypogonadism: New Insights into Relationships Between Genotype and Reproductive Phenotype"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8767-7588","authenticated-orcid":false,"given":"Luca","family":"Giovanelli","sequence":"first","affiliation":[{"name":"Department of Medical Biotechnology & Translational Medicine, University of Milan , 20095 Milan , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-8095","authenticated-orcid":false,"given":"Richard","family":"Quinton","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals NHS Foundation Trust , Newcastle upon Tyne NE1 4LP , UK"},{"name":"Translational & Clinical Research Institute, University of Newcastle-upon-Tyne , Newcastle upon Tyne NE1 4LP , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"issue":"(4)","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1210\/clinem\/dgac615","article-title":"Reproductive phenotypes and genotypes in men with IHH","volume":"108","author":"Dwyer","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00439-020-02147-1","article-title":"Genetics of congenital hypogonadotropic hypogonadism: peculiarities and phenotype of an oligogenic disease","volume":"140","author":"Cangiano","year":"2021","journal-title":"Hum Genet"},{"issue":"2","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1210\/er.2018-00116","article-title":"Clinical management of congenital hypogonadotropic hypogonadism","volume":"40","author":"Young","year":"2019","journal-title":"Endocr Rev"},{"issue":"4","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1530\/EJE-17-0568","article-title":"Congenital hypogonadotropic hypogonadism and constitutional delay of growth and puberty have distinct genetic architectures","volume":"178","author":"Cassatella","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1210\/jc.2009-2582","article-title":"Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus, pituitary, and testes","volume":"95","author":"Sykiotis","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jc.2013-2809","article-title":"Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system","volume":"99","author":"Sidhoum","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"e1441","DOI":"10.1210\/clinem\/dgaa609","article-title":"Increased burden of rare sequence variants in GnRH-associated genes in women with hypothalamic amenorrhea","volume":"106","author":"Delaney","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2023031010321342200_","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.1210\/jc.2018-02697","article-title":"Functional hypogonadotropic hypogonadism in men: underlying neuroendocrine mechanisms and natural history","volume":"104","author":"Dwyer","year":"2019","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac727\/48421232\/dgac727.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/4\/e50\/49499561\/dgac727.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/4\/e50\/49499561\/dgac727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T04:19:05Z","timestamp":1679113145000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/108\/4\/e50\/6911425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,15]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12,15]]},"published-print":{"date-parts":[[2023,3,10]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac727","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,4,1]]},"published":{"date-parts":[[2022,12,15]]}}}