{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:00Z","timestamp":1787021220069,"version":"build-2736575974"},"reference-count":36,"publisher":"The Endocrine Society","issue":"6","license":[{"start":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T00:00:00Z","timestamp":1671148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Conventional treatment of X-linked hypophosphatemia (XLH) was reported to prevent dental complications, but whether the preventive effect was different among different types of teeth, including anterior teeth and molar teeth, is uncertain. Evidence of the preventive effect of conventional treatment on ectopic ossifications is also limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare dental complications and ectopic ossifications among adults with XLH with early (&amp;lt;5 years old) or late (\u22655 years old) conventional treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included a total of 30 adults with XLH; orthopantomograms, spinal computed tomography scans, and X-rays of hip\/knee joints were studied. Dental complications, including the decayed, missing, filled (DMF) index and devitalized teeth, apical periodontitis, and periodontitis, were evaluated. The ossification of the anterior\/posterior longitudinal ligament and yellow ligament indexes (OA\/OP\/OY indexes) and the sum of the OA\/OP\/OY indexes (OS index) were utilized to evaluate the severity of spinal ligament ossification. The severity of the hip\/knee osteophytes was evaluated using the Kellgren\u2013Lawrence (KL) classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The number of sound teeth was significantly lower and the DMF index was significantly higher in patients with late treatment. The severity of dental complications in the anterior tooth and molar tooth, OA\/OP\/OY\/OS index, and KL grade were not significantly different among patients with early treatment and those with late treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early treatment could prevent dental complications but did not prevent ectopic ossification in adult patients with XLH. The difference in the preventive effect was not observed among different types of teeth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgac732","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T08:05:10Z","timestamp":1671177910000},"page":"1405-1414","source":"Crossref","is-referenced-by-count":19,"title":["Effect of Conventional Treatment on Dental Complications and Ectopic Ossifications Among 30 Adults With XLH"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9178-7846","authenticated-orcid":false,"given":"Hajime","family":"Kato","sequence":"first","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"},{"name":"Osteoporosis Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8634-209X","authenticated-orcid":false,"given":"Rena","family":"Okawa","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry , Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-081X","authenticated-orcid":false,"given":"Toru","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5226-2227","authenticated-orcid":false,"given":"Yoshitomo","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"},{"name":"Osteoporosis Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-2247","authenticated-orcid":false,"given":"Naoko","family":"Hidaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"},{"name":"Osteoporosis Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minae","family":"Koga","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"},{"name":"Osteoporosis Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6583-0879","authenticated-orcid":false,"given":"Yuka","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-123X","authenticated-orcid":false,"given":"Yuki","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3610-3469","authenticated-orcid":false,"given":"Seiji","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University , Tokushima 770-0042 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7401-2934","authenticated-orcid":false,"given":"Masaomi","family":"Nangaku","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-115X","authenticated-orcid":false,"given":"Noriko","family":"Makita","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"},{"name":"Osteoporosis Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Hoshi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-2685","authenticated-orcid":false,"given":"Kazuhiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry , Osaka 565-0871 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-5372","authenticated-orcid":false,"given":"Nobuaki","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Endocrinology, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"},{"name":"Osteoporosis Center, The University of Tokyo Hospital , Tokyo 113-8655 , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2022,12,16]]},"reference":[{"issue":"2","key":"2023051701090375800_dgac732-B1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ng1095-130","article-title":"A gene (PEX) with homologies to endopeptidases is mutated in patients with X\u2013linked hypophosphatemic rickets","volume":"11","author":"Francis","year":"1995","journal-title":"Nat Genet"},{"issue":"7","key":"2023051701090375800_dgac732-B2","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jbmr.340","article-title":"A clinician's guide to X-linked hypophosphatemia","volume":"26","author":"Carpenter","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"3","key":"2023051701090375800_dgac732-B3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1210\/er.2017-00220","article-title":"X-linked hypophosphatemia and FGF23-related hypophosphatemic diseases: prospect for new treatment","volume":"39","author":"Kinoshita","year":"2018","journal-title":"Endocr Rev"},{"issue":"7","key":"2023051701090375800_dgac732-B4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41581-019-0152-5","article-title":"Clinical practice recommendations for the diagnosis and management of X-linked hypophosphataemia","volume":"15","author":"Haffner","year":"2019","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"2023051701090375800_dgac732-B5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/s41574-022-00662-x","article-title":"Interdisciplinary management of FGF23-related phosphate wasting syndromes: a consensus statement on the evaluation, diagnosis and care of patients with X-linked hypophosphataemia","volume":"18","author":"Trombetti","year":"2022","journal-title":"Nat Rev Endocrinol"},{"issue":"2","key":"2023051701090375800_dgac732-B6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00223-010-9373-0","article-title":"Phenotype presentation of hypophosphatemic rickets in adults","volume":"87","author":"Beck-Nielsen","year":"2010","journal-title":"Calcif Tissue Int"},{"issue":"9","key":"2023051701090375800_dgac732-B7","doi-asserted-by":"crossref","first-page":"E3682","DOI":"10.1210\/clinem\/dgab282","article-title":"Incidence of complications in 25 adult patients with X-linked hypophosphatemia","volume":"106","author":"Kato","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2023051701090375800_dgac732-B8","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1067\/mpd.2003.119","article-title":"Dental abnormalities in patients with familial hypophosphatemic vitamin D-resistant rickets: prevention by early treatment with 1-hydroxyvitamin D","volume":"142","author":"Chaussain-Miller","year":"2003","journal-title":"J Pediatr"},{"issue":"4","key":"2023051701090375800_dgac732-B9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1177\/0022034516677528","article-title":"Phosphate and vitamin D prevent periodontitis in X-linked hypophosphatemia","volume":"96","author":"Biosse Duplan","year":"2017","journal-title":"J Dent Res"},{"issue":"10","key":"2023051701090375800_dgac732-B10","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1210\/JC.2015-2199","article-title":"Conventional therapy in adults with x-linked hypophosphatemia: effects on enthesopathy and dental disease","volume":"100","author":"Connor","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2023051701090375800_dgac732-B11","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1210\/clinem\/dgac296","article-title":"Effect of burosumab compared with conventional therapy on younger vs older children with X-linked hypophosphatemia","volume":"107","author":"Ward","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2023051701090375800_dgac732-B12","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1210\/clinem\/dgab580","article-title":"Prevalence of enthesopathies in adults with X-linked hypophosphatemia: analysis of risk factors","volume":"107","author":"Herrou","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2023051701090375800_dgac732-B13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1507\/endocrj.EJ15-0275","article-title":"Nationwide survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases in Japan: prevalence, biochemical data and treatment","volume":"62","author":"Endo","year":"2015","journal-title":"Endocr J"},{"issue":"6","key":"2023051701090375800_dgac732-B14","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1007\/s00774-021-01250-1","article-title":"Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF23","volume":"39","author":"Ito","year":"2021","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"2023051701090375800_dgac732-B15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00774-021-01258-7","article-title":"Performance evaluation of the new chemiluminescent intact FGF23 assay relative to the existing assay system","volume":"40","author":"Kato","year":"2022","journal-title":"J Bone Miner Metab"},{"issue":"2","key":"2023051701090375800_dgac732-B16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1530\/EJE-12-0071","article-title":"Mutational analysis of patients with FGF23-related hypophosphatemic rickets","volume":"167","author":"Kinoshita","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"2023051701090375800_dgac732-B17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.jmoldx.2018.04.004","article-title":"Assessing the accuracy of variant detection in cost-effective gene panel testing by next-generation sequencing","volume":"20","author":"Fujiki","year":"2018","journal-title":"J Mol Diagn"},{"key":"2023051701090375800_dgac732-B18","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1034\/j.1600-051x.2000.027012960.x","article-title":"Diagnosis of periodontitis","volume":"27","author":"van der Velden","year":"2000","journal-title":"J Clin Periodontol"},{"key":"2023051701090375800_dgac732-B19","author":"Ministry of Health, Labour and Welfare (Japan)"},{"issue":"4","key":"2023051701090375800_dgac732-B20","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jos.2016.04.009","article-title":"Characteristics of ossification of the spinal ligament; incidence of ossification of the ligamentum flavum in patients with cervical ossification of the posterior longitudinal ligament \u2013 analysis of the whole spine using multidetector CT","volume":"21","author":"Kawaguchi","year":"2016","journal-title":"J Orthop Sci"},{"issue":"8","key":"2023051701090375800_dgac732-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0160117","article-title":"Prevalence and distribution of ossified lesions in the whole spine of patients with cervical ossification of the posterior longitudinal ligament a multicenter study (JOSL CT study)","volume":"11","author":"Hirai","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"2023051701090375800_dgac732-B22","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"2023051701090375800_dgac732-B23","author":"Kato"},{"issue":"1","key":"2023051701090375800_dgac732-B24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1365-263X.1998.00059.x","article-title":"Dental problems associated with hypophosphataemic vitamin D resistant rickets","volume":"8","author":"Goodman","year":"1998","journal-title":"Int J Paediatr Dent"},{"issue":"3","key":"2023051701090375800_dgac732-B25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1067\/moe.2000.107522","article-title":"Familial hypophosphatemic vitamin D-resistant rickets: dental findings and histologic study of teeth","volume":"90","author":"Murayama","year":"2000","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"issue":"4","key":"2023051701090375800_dgac732-B26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00004770-200404000-00015","article-title":"Dental alterations associated with X-linked hypophosphatemic rickets","volume":"30","author":"Pereira","year":"2004","journal-title":"J Endod"},{"issue":"2","key":"2023051701090375800_dgac732-B27","first-page":"61","article-title":"Prevalence and pathogenesis of dental and periodontal lesions in children with X-linked hypophosphatemic rickets","volume":"7","author":"Baroncelli","year":"2006","journal-title":"Eur J Paediatr Dent"},{"issue":"11","key":"2023051701090375800_dgac732-B28","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1902\/jop.2011.100736","article-title":"Periodontal Status of patients with hypophosphatemic rickets: a case series","volume":"82","author":"Ye","year":"2011","journal-title":"J Periodontol"},{"issue":"4","key":"2023051701090375800_dgac732-B29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/sca.21141","article-title":"X-linked hypophosphatemic rickets: enamel abnormalities and oral clinical findings","volume":"36","author":"Cremonesi","year":"2014","journal-title":"Scanning"},{"issue":"2","key":"2023051701090375800_dgac732-B30","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1365-2842.2011.02250.x","article-title":"Periapical and endodontic status of permanent teeth in patients with hypophosphatemic rickets","volume":"39","author":"Andersen","year":"2012","journal-title":"J Oral Rehabil"},{"issue":"4","key":"2023051701090375800_dgac732-B31","doi-asserted-by":"crossref","first-page":"e10463","DOI":"10.1002\/jbm4.10463","article-title":"Mineralization defects in the primary dentition associated with X-linked hypophosphatemic rickets","volume":"5","author":"Clayton","year":"2021","journal-title":"JBMR Plus"},{"issue":"2","key":"2023051701090375800_dgac732-B32","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s00774-020-01136-8","article-title":"Pulp chamber features, prevalence of abscesses, disease severity, and PHEX mutation in X-linked hypophosphatemic rickets","volume":"39","author":"Baroncelli","year":"2021","journal-title":"J Bone Miner Metab"},{"issue":"2","key":"2023051701090375800_dgac732-B33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.joen.2011.10.025","article-title":"Endodontic management in a patient with vitamin D-resistant rickets","volume":"38","author":"Beltes","year":"2012","journal-title":"J Endod"},{"issue":"2","key":"2023051701090375800_dgac732-B34","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1148\/radiology.171.2.2539609","article-title":"X-linked hypophosphatemia in adults: prevalence of skeletal radiographic and scintigraphic features","volume":"171","author":"Hardy","year":"1989","journal-title":"Radiology"},{"issue":"3","key":"2023051701090375800_dgac732-B35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00223-009-9270-6","article-title":"Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice","volume":"85","author":"Liang","year":"2009","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"2023051701090375800_dgac732-B36","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1530\/EJE-15-0661","article-title":"Impaired quality of life in adults with X-linked hypophosphatemia and skeletal symptoms","volume":"174","author":"Che","year":"2016","journal-title":"Eur J Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgac732\/48515464\/dgac732.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/6\/1405\/50355190\/dgac732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/6\/1405\/50355190\/dgac732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T21:11:04Z","timestamp":1684271464000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/108\/6\/1405\/6916834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":36,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,12,16]]},"published-print":{"date-parts":[[2023,5,17]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgac732","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,6]]},"published":{"date-parts":[[2022,12,16]]}}}