{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:28:51Z","timestamp":1792290531696,"version":"4.4.0"},"reference-count":29,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Preconception optimization of thyroid function in women with Hashimoto thyroiditis (HT) is highly recommended to prevent\/reduce the risk of thyroid insufficiency at early gestation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work aimed to evaluate the prevalence of first-trimester thyroid insufficiency in HT women with preconception thyrotropin (T0-TSH) values consistently less than or equal to 2.5 mIU\/L with or without levothyroxine (LT4) treatment, and to calculate T0-TSH cutoffs that best preconceptionally identified HT women requiring first-trimester LT4 adjustment\/prescription.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serum TSH was obtained at 4- to 6-week intervals from 260 HT pregnant women (122 on LT4 [Hypo-HT]; 138 euthyroid without LT4 [Eu-HT]), prospectively followed from preconception up to pregnancy term. Receiver operating characteristic (ROC) curves were plotted to identify T0-TSH cutoffs best predicting first-trimester TSH levels greater than 2.5 mIU\/L (diagnostic criterion [DC] 1) and greater than 4.0 mIU\/L (DC 2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At first trimester, TSH was greater than 2.5 mIU\/L in approximately 30% of both Hypo-HT and Eu-HT women, and greater than 4.0 mIU\/L in 19.7% Hypo-HT and 10.1% Eu-HT women (P = .038). The optimal ROC-based T0-TSH cutoffs found were 1.24 mIU\/L\/1.74 mIU\/L in Hypo-HT, and 1.73 mIU\/L\/2.07 mIU\/L in Eu-HT women, for DC 1 and DC 2, respectively. T0-TSH values exceeding these cutoffs resulted in a statistically significantly increased risk of first-trimester thyroid insufficiency (odds ratio [OR] [95% CI)] 15.92 [5.06-50.15] and 16.68 [5.13-54.24] in Hypo-HT; 16.14 [6.47-40.30] and 17.36 [4.30-70.08] in Eu-HT women, for DC 1 and DC 2, respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The preconception TSH cutoffs that guaranteed a first-trimester TSH less than 2.5 mU\/L in hypothyroid- and euthyroid-HT women were, respectively, almost 50% (1.24 mU\/L) and 30% (1.73 mU\/L) lower than this gestational target, and 1.74 mU\/L and 2.07 mU\/L in hypothyroid- and euthyroid-HT women, respectively, for a gestational target of 4.0 mU\/L.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgac748","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T08:49:36Z","timestamp":1673254176000},"page":"e464-e473","source":"Crossref","is-referenced-by-count":6,"title":["Preconception Thyrotropin Levels and Thyroid Function at Early Gestation in Women With Hashimoto Thyroiditis"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8686-1615","authenticated-orcid":false,"given":"Mariacarla","family":"Moleti","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-151X","authenticated-orcid":false,"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Dipartimento di Economia, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Di Mauro","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Paola","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Giovanna","family":"Perdichizzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Granese","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Giacobbe","sequence":"additional","affiliation":[{"name":"Dipartimento Assistenziale Integrato Materno Infantile, Azienda Ospedaliera Universitaria Policlinico G. Martino , Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Scilipoti","sequence":"additional","affiliation":[{"name":"Dipartimento Assistenziale Integrato Materno Infantile, Azienda Ospedaliera Universitaria Policlinico G. Martino , Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ragonese","sequence":"additional","affiliation":[{"name":"Dipartimento di Patologia Umana dell\u2019adulto e dell\u2019et\u00e0 Evolutiva Gaetano Barresi, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ercoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, Universit\u00e0 degli Studi di Messina , 98125 Messina , Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Benvenga","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale, Universit\u00e0 degli Studi di Messina , 98125 Messina , 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