{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:32:10Z","timestamp":1785537130750,"version":"3.56.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23DK117041"],"award-info":[{"award-number":["K23DK117041"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Ketogenic diets (KDs) and low-fat diets (LFD) result in similar weight loss, but have differential cardiometabolic effects on lipids and insulin. Generally, weight loss decreases renin\u2013angiotensin\u2013aldosterone system (RAAS) activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Investigate the effects of KDs with varying sodium content vs LFD on RAAS in overweight and obese adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Twenty-eight participants were randomized 1:1 to a KD + ketone salt supplement (KD + KS) or a KD + placebo (KD + PL) arm with prepared hypocaloric meals. Twelve participants were enrolled in a post hoc LFD arm. Serum renin, aldosterone, and anthropometric and metabolic biomarkers were assessed at 0, 2, 4, and 6 weeks. Linear mixed models with random intercepts were used to compare between group differences controlling for sex and body mass index.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Participants had a median age of 33 years, 51% female, weighed 91.3 kg, with body mass index 30.6 kg\/m2. At 6 weeks, weight decreased by 6, 8, and 7 kg on average in the KD + KS, KD + PL, and LFD groups, respectively (P &amp;lt; .05). Aldosterone increased by 88% and 144% in the KD + PL and KD + KS groups, respectively, but did not change in the LFD after 6 weeks while renin decreased across groups. Systolic and diastolic blood pressure did not change in the KD + PL and KD + KS groups. Log ketones were positively associated with aldosterone (P &amp;lt; .001). Aldosterone was not associated with cardiovascular measures including blood pressure and ejection fraction (P &amp;gt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>KD reduced weight and increased aldosterone without worsening cardiometabolic risk factors. Future KD studies are needed to elucidate mechanistic connections between ketones and aldosterone.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad009","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T15:28:06Z","timestamp":1673450886000},"page":"1727-1739","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Hypocaloric Low-Fat, Ketogenic, and Ketogenic and Ketone Supplement Diets on Aldosterone and Renin"],"prefix":"10.1210","volume":"108","author":[{"given":"Paul","family":"Belany","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison L","family":"Kackley","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, The Ohio State University , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songzhu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, The Ohio State University , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjorn","family":"Kluwe","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Buga","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics and Center for Biostatistics, The Ohio State University Wexner Medical Center , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D","family":"Crabtree","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, The Ohio State University , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Nedungadi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-3303","authenticated-orcid":false,"given":"David","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics and Center for Biostatistics, The Ohio State University Wexner Medical Center , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Brock","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics and Center for Biostatistics, The Ohio State University Wexner Medical Center , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando P","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Department of Radiology, Davis Heart & Lung Research Institute, The Ohio State University , Columbus, OH 43210 , USA"},{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, The Ohio State University , Columbus, OH 43210 , USA"},{"name":"Department of Radiology, Wexner Medical Center, The Ohio State University , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8702-0351","authenticated-orcid":false,"given":"Jeff S","family":"Volek","sequence":"additional","affiliation":[{"name":"Department of Human Sciences, The Ohio State University , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-8261","authenticated-orcid":false,"given":"Joshua J","family":"Joseph","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine , Columbus, OH 43210 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"issue":"3","key":"2023061601033218700_dgad009-B1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s13668-018-0235-0","article-title":"Nutritional ketosis for weight management and reversal of metabolic syndrome","volume":"7","author":"Gershuni","year":"2018","journal-title":"Curr Nutr Rep"},{"issue":"5","key":"2023061601033218700_dgad009-B2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrneph.2010.30","article-title":"Aldosterone: effects on the kidney and cardiovascular system","volume":"6","author":"Briet","year":"2010","journal-title":"Nat Rev Nephrol"},{"issue":"6","key":"2023061601033218700_dgad009-B3","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1097\/00004872-198900076-00099","article-title":"Regulation of cardiac output during aldosterone-induced hypertension","volume":"7","author":"Montani","year":"1989","journal-title":"J Hypertens Suppl"},{"issue":"8","key":"2023061601033218700_dgad009-B4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nrneph.2013.110","article-title":"Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis","volume":"9","author":"Brown","year":"2013","journal-title":"Nat Rev Nephrol"},{"issue":"19","key":"2023061601033218700_dgad009-B5","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1016\/j.jacc.2017.11.006","article-title":"2017 ACC\/AHA\/AAPA\/ABC\/ACPM\/AGS\/APhA\/ASH\/ASPC\/NMA\/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults","volume":"71","author":"Whelton","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"2023061601033218700_dgad009-B6","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","article-title":"2017 ACC\/AHA\/HFSA focused update of the 2013 ACCF\/AHA guideline for the management of heart failure","volume":"70","author":"Yancy","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"2023061601033218700_dgad009-B7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.steroids.2014.08.016","article-title":"Effects of aldosterone on insulin sensitivity and secretion","volume":"91","author":"Luther","year":"2014","journal-title":"Steroids"},{"issue":"16","key":"2023061601033218700_dgad009-B8","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1056\/NEJM198104163041602","article-title":"The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients","volume":"304","author":"Tuck","year":"1981","journal-title":"N Engl J Med"},{"issue":"3","key":"2023061601033218700_dgad009-B9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.HYP.0000154361.47683.d3","article-title":"Weight loss and the renin-angiotensin-aldosterone system","volume":"45","author":"Engeli","year":"2005","journal-title":"Hypertension"},{"issue":"9","key":"2023061601033218700_dgad009-B10","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1055\/s-2007-985354","article-title":"Moderate weight loss reduces renin and aldosterone but does not influence basal or stimulated pituitary-adrenal axis function","volume":"39","author":"Ho","year":"2007","journal-title":"Horm Metab Res"},{"issue":"10","key":"2023061601033218700_dgad009-B11","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/hr.2013.45","article-title":"Changes in serum aldosterone are associated with changes in obesity-related factors in normotensive overweight and obese young adults","volume":"36","author":"Cooper","year":"2013","journal-title":"Hypertens Res"},{"issue":"2","key":"2023061601033218700_dgad009-B12","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.numecd.2008.06.001","article-title":"Effect of weight loss through laparoscopic gastric banding on blood pressure, plasma renin activity and aldosterone levels in morbid obesity","volume":"19","author":"Dall\u2019Asta","year":"2009","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"2023061601033218700_dgad009-B13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/j.1550-8528.1999.tb00418.x","article-title":"Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women","volume":"7","author":"Goodfriend","year":"1999","journal-title":"Obes Res"},{"issue":"10","key":"2023061601033218700_dgad009-B14","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/oby.2002.134","article-title":"Dietary weight loss decreases serum angiotensin-converting enzyme activity in obese adults","volume":"10","author":"Harp","year":"2002","journal-title":"Obes Res"},{"key":"2023061601033218700_dgad009-B15","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/472396","article-title":"Blood pressure-lowering mechanisms of the DASH dietary pattern","volume":"2012","author":"Lin","year":"2012","journal-title":"J Nutr Metab"},{"issue":"8","key":"2023061601033218700_dgad009-B16","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0002-9149(86)90845-3","article-title":"Role for aldosterone in blood pressure regulation of obese adolescents","volume":"57","author":"Rocchini","year":"1986","journal-title":"Am J Cardiol"},{"issue":"2","key":"2023061601033218700_dgad009-B17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/07315724.1985.10720078","article-title":"Effect of weight reduction on the renin-aldosterone axis","volume":"4","author":"Vaswani","year":"1985","journal-title":"J Am Coll Nutr"},{"issue":"3","key":"2023061601033218700_dgad009-B18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ajcn\/44.3.341","article-title":"High-carbohydrate diet: antinatriuretic and blood pressure response in normal men","volume":"44","author":"Affarah","year":"1986","journal-title":"Am J Clin Nutr"},{"key":"2023061601033218700_dgad009-B19","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.618520","article-title":"The effects of a 6-week controlled, hypocaloric ketogenic diet, with and without exogenous ketone salts, on body composition responses","volume":"8","author":"Buga","year":"2021","journal-title":"Front Nutr"},{"issue":"3","key":"2023061601033218700_dgad009-B20","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3390\/nu13030966","article-title":"Comparison of ketogenic diets with and without ketone salts versus a low-fat diet: liver fat responses in overweight adults","volume":"13","author":"Crabtree","year":"2021","journal-title":"Nutrients"},{"issue":"8","key":"2023061601033218700_dgad009-B21","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/ejcn.2013.116","article-title":"Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets","volume":"67","author":"Paoli","year":"2013","journal-title":"Eur J Clin Nutr"},{"issue":"12","key":"2023061601033218700_dgad009-B22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128308","article-title":"Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss","volume":"4","author":"Hyde","year":"2019","journal-title":"JCI Insight"},{"issue":"11","key":"2023061601033218700_dgad009-B23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113605","article-title":"Effects of step-wise increases in dietary carbohydrate on circulating saturated fatty acids and palmitoleic acid in adults with metabolic syndrome","volume":"9","author":"Volk","year":"2014","journal-title":"PLoS One"},{"key":"2023061601033218700_dgad009-B24","doi-asserted-by":"publisher","author":"Belany","DOI":"10.6084\/M9.FIGSHARE.21569226.V1"},{"issue":"5","key":"2023061601033218700_dgad009-B25","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1055\/s-0034-1398575","article-title":"Congruent validity and reliability of two metabolic systems to measure resting metabolic rate","volume":"36","author":"Welch","year":"2015","journal-title":"Int J Sports Med"},{"issue":"7","key":"2023061601033218700_dgad009-B26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"6","key":"2023061601033218700_dgad009-B27","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvac049","article-title":"Recalibrating interpretations of aldosterone assays across the physiologic range: immunoassay and liquid chromatography-tandem mass spectrometry measurements under multiple controlled conditions","volume":"6","author":"Brown","year":"2022","journal-title":"J Endocr Soc"},{"issue":"4","key":"2023061601033218700_dgad009-B28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.18383\/j.tom.2019.00018","article-title":"Quantification of human central adipose tissue depots: an anatomically matched comparison between DXA and MRI","volume":"5","author":"Crabtree","year":"2019","journal-title":"Tomography"},{"issue":"7","key":"2023061601033218700_dgad009-B29","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1210\/jc.2008-0251","article-title":"Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients","volume":"93","author":"Rossi","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"2023061601033218700_dgad009-B30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/sj.ijo.0801483","article-title":"Insulin, renin-aldosterone system and blood pressure in obese people","volume":"25","author":"Andronico","year":"2001","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"5","key":"2023061601033218700_dgad009-B31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/HYPERTENSIONAHA.111.190223","article-title":"Adipocytes produce aldosterone through calcineurin-dependent signaling pathways","volume":"59","author":"Briones","year":"2012","journal-title":"Hypertension"},{"issue":"5","key":"2023061601033218700_dgad009-B32","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/01.HYP.4.5.686","article-title":"Blood pressure and hormone changes associated with weight reduction in the obese","volume":"4","author":"Sowers","year":"1982","journal-title":"Hypertension"},{"issue":"1","key":"2023061601033218700_dgad009-B33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa033263","article-title":"Serum aldosterone and the incidence of hypertension in nonhypertensive persons","volume":"351","author":"Vasan","year":"2004","journal-title":"N Engl J Med"},{"issue":"17","key":"2023061601033218700_dgad009-B34","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009890","article-title":"Renin-angiotensin-aldosterone system, glucose metabolism and incident type 2 diabetes mellitus: MESA","volume":"7","author":"Joseph","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"2023061601033218700_dgad009-B35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10741-005-2346-0","article-title":"Effect of aldosterone and mineralocorticoid receptor blockade on vascular inflammation","volume":"10","author":"Joffe","year":"2005","journal-title":"Heart Fail Rev"},{"issue":"9","key":"2023061601033218700_dgad009-B36","first-page":"963","article-title":"Mineralocorticoid receptor antagonists and endothelial function","volume":"9","author":"Maron","year":"2008","journal-title":"Curr Opin Investig Drugs"},{"issue":"2","key":"2023061601033218700_dgad009-B37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1161\/HYPERTENSIONAHA.107.095489","article-title":"Aldosterone and vascular inflammation","volume":"51","author":"Brown","year":"2008","journal-title":"Hypertension"},{"issue":"23","key":"2023061601033218700_dgad009-B38","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1161\/CIRCULATIONAHA.116.024369","article-title":"NLRP3 inflammasome mediates aldosterone-induced vascular damage","volume":"134","author":"Bruder-Nascimento","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"2023061601033218700_dgad009-B39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"Ketone body \u03b2-hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat Med"},{"issue":"4","key":"2023061601033218700_dgad009-B40","first-page":"437","article-title":"Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-a, IL-1b, IL-6 in spontaneously hypertensive rats (SHR)","volume":"59","author":"Andrzejczak","year":"2007","journal-title":"Pharmacol Rep"},{"issue":"3","key":"2023061601033218700_dgad009-B41","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1189\/jlb.0404221","article-title":"Differing caspase-1 activation states in monocyte versus macrophage models of IL-1\u03b2 processing and release","volume":"76","author":"Kahlenberg","year":"2004","journal-title":"J Leukoc Biol"},{"issue":"1","key":"2023061601033218700_dgad009-B42","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/s41467-020-15983-6","article-title":"SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease","volume":"11","author":"Kim","year":"2020","journal-title":"Nat Commun"},{"issue":"12","key":"2023061601033218700_dgad009-B43","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"issue":"7","key":"2023061601033218700_dgad009-B44","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N Engl J Med"},{"issue":"22","key":"2023061601033218700_dgad009-B45","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes","volume":"373","author":"Zinman","year":"2015","journal-title":"N Engl J Med"},{"issue":"1","key":"2023061601033218700_dgad009-B46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11745-007-3132-7","article-title":"Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation","volume":"43","author":"Forsythe","year":"2008","journal-title":"Lipids"},{"issue":"4","key":"2023061601033218700_dgad009-B47","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S0008-6363(01)00503-X","article-title":"Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective","volume":"53","author":"Bradham","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"5","key":"2023061601033218700_dgad009-B48","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/ni.3153","article-title":"IL-6 as a keystone cytokine in health and disease","volume":"16","author":"Hunter","year":"2015","journal-title":"Nat Immunol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgad009\/49086953\/dgad009.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/7\/1727\/50604599\/dgad009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/7\/1727\/50604599\/dgad009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:05:12Z","timestamp":1686881112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/108\/7\/1727\/6983966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":48,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,1,11]]},"published-print":{"date-parts":[[2023,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgad009","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,1,11]]}}}