{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:50:39Z","timestamp":1773269439561,"version":"3.50.1"},"reference-count":51,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Thyroid-stimulating hormone (TSH), as the most sensitive and specific marker of thyroid status, is associated with multiple health outcomes, including mortality. However, whether TSH levels are causally associated with the risk of mortality remains unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aims to investigate the causal association between TSH levels and all-cause mortality using Mendelian randomization (MR) analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>MR analyses using single-nucleotide polymorphisms (SNPs) associated with TSH levels (P &amp;lt; 5 \u00d7 10\u22128) as instruments. Mortality data were obtained from the UK Biobank, including 384 344 participants who were recruited from 22 assessment centers across the UK taken between 2006 and 2010. Cox proportional hazards regression was used to estimate the association of the TSH genetic risk score (GRS) with all-cause and cause-specific mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>15 557 individuals died during a median of 9.00 years of follow-up in the UK Biobank. A total of 70 SNPs were included in the MR analysis. The main MR analyses showed that 1 SD increase in TSH was associated with a decreased risk of all-cause mortality (OR 0.972, 95% CI 0.948-0.996), which may be largely attributed to respiratory disease mortality (OR 0.881, 95% CI 0.805-0.963). The multivariable hazard ratios (HRs) (95% CI) of all-cause mortality across 3 TSH GRS categories were 1.00 (reference), 0.976 (0.940-1.014), and 0.947 (0.911-0.985), respectively (P for trend &amp;lt; .01). Moreover, except digestive diseases mortality, genetically predicted TSH levels were negatively associated with mortality from CVD, cancer, noncancer diseases causes, and dementia, although not statistically significant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Higher TSH levels were causally associated with lower risk of all-cause mortality, which may be largely attributed to respiratory disease mortality.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad025","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T03:42:04Z","timestamp":1674186124000},"page":"e396-e403","source":"Crossref","is-referenced-by-count":1,"title":["Association of Thyroid-Stimulating Hormone With All-Cause Mortality: A 2-Sample Mendelian Randomization Study"],"prefix":"10.1210","volume":"108","author":[{"given":"Yeqing","family":"Gu","sequence":"first","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zimin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center , Beijing 100817 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingkui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health of Tianjin University of Traditional Chinese Medicine , Tianjin 301617 , China"},{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqi","family":"Song","sequence":"additional","affiliation":[{"name":"School of Public Health of Tianjin University of Traditional Chinese Medicine , Tianjin 301617 , China"},{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Meng","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health of Tianjin University of Traditional Chinese Medicine , Tianjin 301617 , China"},{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuena","family":"Wang","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinran","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-1368","authenticated-orcid":false,"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center , Beijing 100817 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-2474","authenticated-orcid":false,"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Westlake University , Hangzhou 310024 , China"},{"name":"Westlake Laboratory of Life Sciences and Biomedicine, Westlake University , Hangzhou 310024 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-2481","authenticated-orcid":false,"given":"Kaijun","family":"Niu","sequence":"additional","affiliation":[{"name":"Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Tianjin 300192 , China"},{"name":"School of Public Health of Tianjin University of Traditional Chinese Medicine , Tianjin 301617 , China"},{"name":"Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University , Tianjin 300070 , China"},{"name":"Tianjin Key Laboratory of Environment, Nutrition and Public Health , Tianjin 300070 , China"},{"name":"Center for International Collaborative Research on Environment, Nutrition and Public Health , Tianjin 300070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"2","key":"2023061601041195700_dgad025-B1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1210\/er.2009-0007","article-title":"Molecular aspects of thyroid hormone actions","volume":"31","author":"Cheng","year":"2010","journal-title":"Endocr Rev"},{"issue":"9","key":"2023061601041195700_dgad025-B2","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1172\/JCI60047","article-title":"Mechanisms of thyroid hormone action","volume":"122","author":"Brent","year":"2012","journal-title":"J Clin Invest"},{"issue":"6","key":"2023061601041195700_dgad025-B3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/cen.12824","article-title":"Management of primary hypothyroidism: statement by the British Thyroid Association Executive Committee","volume":"84","author":"Okosieme","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"10101","key":"2023061601041195700_dgad025-B4","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1016\/S0140-6736(17)30703-1","article-title":"Hypothyroidism","volume":"390","author":"Chaker","year":"2017","journal-title":"Lancet"},{"issue":"10047","key":"2023061601041195700_dgad025-B5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","article-title":"Hyperthyroidism","volume":"388","author":"De Leo","year":"2016","journal-title":"Lancet"},{"issue":"5","key":"2023061601041195700_dgad025-B6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nrendo.2018.18","article-title":"Global epidemiology of hyperthyroidism and hypothyroidism","volume":"14","author":"Taylor","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"2023061601041195700_dgad025-B7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/cen.13472","article-title":"Thyroid-stimulating hormone and risk of sudden cardiac death, total mortality and cardiovascular morbidity","volume":"88","author":"Langen","year":"2018","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"6","key":"2023061601041195700_dgad025-B8","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.5114\/aoms.2016.63264","article-title":"High-normal thyroid-stimulating hormone in euthyroid subjects is associated with risk of mortality and composite disease endpoint only in women","volume":"14","author":"Altay","year":"2018","journal-title":"Arch Med Sci"},{"issue":"3","key":"2023061601041195700_dgad025-B9","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/jgs.14029","article-title":"Relationship between circulating thyroid-stimulating hormone, free thyroxine, and free triiodothyronine concentrations and 9-year mortality in euthyroid elderly adults","volume":"64","author":"Ceresini","year":"2016","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"2023061601041195700_dgad025-B10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s12020-020-02397-z","article-title":"Thyroid function and risk of all-cause and cardiovascular mortality: a prospective population-based cohort study","volume":"71","author":"Groothof","year":"2021","journal-title":"Endocrine"},{"issue":"21","key":"2023061601041195700_dgad025-B11","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1001\/jama.292.21.2591","article-title":"Thyroid status, disability and cognitive function, and survival in old age","volume":"292","author":"Gussekloo","year":"2004","journal-title":"JAMA"},{"issue":"2","key":"2023061601041195700_dgad025-B12","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.20745","article-title":"Association of subclinical hypothyroidism and cardiovascular disease with mortality","volume":"3","author":"Inoue","year":"2020","journal-title":"JAMA Netw Open"},{"issue":"9","key":"2023061601041195700_dgad025-B13","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/thy.2017.0414","article-title":"Subclinical hypothyroidism and the risk of cardiovascular disease and all-cause mortality: a meta-analysis of prospective cohort studies","volume":"28","author":"Moon","year":"2018","journal-title":"Thyroid"},{"issue":"4","key":"2023061601041195700_dgad025-B14","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.amjcard.2018.03.371","article-title":"Relation of subclinical hypothyroidism is associated with cardiovascular events and all-cause mortality in adults with high cardiovascular risk","volume":"122","author":"Moon","year":"2018","journal-title":"Am J Cardiol"},{"issue":"12","key":"2023061601041195700_dgad025-B15","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1001\/jama.2010.1361","article-title":"Subclinical hypothyroidism and the risk of coronary heart disease and mortality","volume":"304","author":"Rodondi","year":"2010","journal-title":"JAMA"},{"issue":"4","key":"2023061601041195700_dgad025-B16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0122955","article-title":"Subclinical hypothyroidism is associated with increased risk for cancer mortality in adult Taiwanese-a 10 years population-based cohort","volume":"10","author":"Tseng","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"2023061601041195700_dgad025-B17","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jacc.2012.03.047","article-title":"Subclinical hypothyroidism is associated with increased risk for all-cause and cardiovascular mortality in adults","volume":"60","author":"Tseng","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"2023061601041195700_dgad025-B18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s12020-020-02216-5","article-title":"The association of thyroid stimulation hormone levels with incident ischemic heart disease, incident stroke, and all-cause mortality","volume":"68","author":"Mollehave","year":"2020","journal-title":"Endocrine"},{"issue":"8","key":"2023061601041195700_dgad025-B19","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/sim.3034","article-title":"Mendelian randomization: using genes as instruments for making causal inferences in epidemiology","volume":"27","author":"Lawlor","year":"2008","journal-title":"Stat Med"},{"issue":"2","key":"2023061601041195700_dgad025-B20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003266","article-title":"A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function","volume":"9","author":"Porcu","year":"2013","journal-title":"PLoS Genet"},{"issue":"1","key":"2023061601041195700_dgad025-B21","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.1038\/ncomms6681","article-title":"Whole-genome sequence-based analysis of thyroid function","volume":"6","author":"Taylor","year":"2015","journal-title":"Nat Commun"},{"issue":"1","key":"2023061601041195700_dgad025-B22","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1038\/s41467-018-06356-1","article-title":"Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation","volume":"9","author":"Teumer","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"2023061601041195700_dgad025-B23","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1038\/s41467-020-17718-z","article-title":"GWAS Of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"2023061601041195700_dgad025-B24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"issue":"7726","key":"2023061601041195700_dgad025-B25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"2023061601041195700_dgad025-B26","author":"Gu"},{"issue":"12","key":"2023061601041195700_dgad025-B27","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1093\/aje\/kwr026","article-title":"Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses","volume":"173","author":"Palmer","year":"2011","journal-title":"Am J Epidemiol"},{"issue":"11","key":"2023061601041195700_dgad025-B28","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1002\/sim.7221","article-title":"A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization","volume":"36","author":"Bowden","year":"2017","journal-title":"Stat Med"},{"key":"2023061601041195700_dgad025-B29","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.920510","article-title":"Genetically predicted adiponectin causally reduces the risk of chronic kidney disease, a bilateral and multivariable Mendelian randomization study","volume":"13","author":"Wu","year":"2022","journal-title":"Front Genet"},{"issue":"3","key":"2023061601041195700_dgad025-B30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s10654-021-00721-z","article-title":"Thyroid function, sex hormones and sexual function: a Mendelian randomization study","volume":"36","author":"Kjaergaard","year":"2021","journal-title":"Eur J Epidemiol"},{"issue":"7","key":"2023061601041195700_dgad025-B31","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1002\/ijc.32988","article-title":"Causal associations of thyroid function and dysfunction with overall, breast and thyroid cancer: A two-sample Mendelian randomization study","volume":"147","author":"Yuan","year":"2020","journal-title":"Int J Cancer"},{"issue":"6","key":"2023061601041195700_dgad025-B32","first-page":"1961","article-title":"Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic","volume":"45","author":"Bowden","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"4","key":"2023061601041195700_dgad025-B33","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/gepi.22295","article-title":"A comparison of robust Mendelian randomization methods using summary data","volume":"44","author":"Slob","year":"2020","journal-title":"Genet Epidemiol"},{"issue":"1","key":"2023061601041195700_dgad025-B34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41467-019-14156-4","article-title":"A robust and efficient method for Mendelian randomization with hundreds of genetic variants","volume":"11","author":"Burgess","year":"2020","journal-title":"Nat Commun"},{"issue":"9285","key":"2023061601041195700_dgad025-B35","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(01)06067-6","article-title":"Prediction of all-cause and cardiovascular mortality in elderly people from one low serum thyrotropin result: a 10-year cohort study","volume":"358","author":"Parle","year":"2001","journal-title":"Lancet"},{"issue":"2","key":"2023061601041195700_dgad025-B36","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1001\/jamacardio.2018.4635","article-title":"Assessment of the relationship between genetic determinants of thyroid function and atrial fibrillation: a Mendelian randomization study","volume":"4","author":"Ellervik","year":"2019","journal-title":"JAMA Cardiol"},{"issue":"12","key":"2023061601041195700_dgad025-B37","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.3390\/jpm11121306","article-title":"Association of thyroid function with blood pressure and cardiovascular disease: a Mendelian randomization","volume":"11","author":"Giontella","year":"2021","journal-title":"J Pers Med"},{"issue":"8","key":"2023061601041195700_dgad025-B38","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/clinem\/dgaa239","article-title":"Thyroid function affects the risk of stroke via atrial fibrillation: a Mendelian randomization study","volume":"105","author":"Marouli","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"2023061601041195700_dgad025-B39","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1089\/thy.2021.0321","article-title":"Thyroid function and the risk of Alzheimer's disease: a Mendelian randomization study","volume":"31","author":"Marouli","year":"2021","journal-title":"Thyroid"},{"issue":"11","key":"2023061601041195700_dgad025-B40","doi-asserted-by":"crossref","first-page":"e4400","DOI":"10.1210\/clinem\/dgab478","article-title":"Comparative effectiveness of levothyroxine, desiccated thyroid extract, and levothyroxine + liothyronine in hypothyroidism","volume":"106","author":"Shakir","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"2023061601041195700_dgad025-B41","doi-asserted-by":"crossref","first-page":"1583S","DOI":"10.1093\/jn\/132.6.1583S","article-title":"Living fast, dying when? The link between aging and energetics","volume":"132","author":"Speakman","year":"2002","journal-title":"J Nutr"},{"issue":"11","key":"2023061601041195700_dgad025-B42","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1001\/jamainternmed.2017.4836","article-title":"Association of thyroid function with life expectancy with and without cardiovascular disease: the Rotterdam study","volume":"177","author":"Bano","year":"2017","journal-title":"JAMA Intern Med"},{"issue":"15","key":"2023061601041195700_dgad025-B43","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1161\/CIRCULATIONAHA.106.678326","article-title":"Thyroid disease and the heart","volume":"116","author":"Klein","year":"2007","journal-title":"Circulation"},{"issue":"12","key":"2023061601041195700_dgad025-B44","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1160\/TH12-07-0496","article-title":"The effect of hyperthyroidism on procoagulant, anticoagulant and fibrinolytic factors: a systematic review and meta-analysis","volume":"108","author":"Stuijver","year":"2012","journal-title":"Thromb Haemost"},{"issue":"1-2","key":"2023061601041195700_dgad025-B45","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0303-7207(00)00302-6","article-title":"Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart","volume":"168","author":"Lopez-Torres","year":"2000","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"2023061601041195700_dgad025-B46","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1365-2826.2008.01774.x","article-title":"The thyroid-brain interaction in thyroid disorders and mood disorders","volume":"20","author":"Bauer","year":"2008","journal-title":"J Neuroendocrinol"},{"issue":"16","key":"2023061601041195700_dgad025-B47","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1212\/WNL.0000000000003227","article-title":"Thyroid function and the risk of dementia: the Rotterdam study","volume":"87","author":"Chaker","year":"2016","journal-title":"Neurology"},{"issue":"20","key":"2023061601041195700_dgad025-B48","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1001\/jama.2015.5161","article-title":"Subclinical thyroid dysfunction and fracture risk: a meta-analysis","volume":"313","author":"Blum","year":"2015","journal-title":"JAMA"},{"issue":"10","key":"2023061601041195700_dgad025-B49","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/CIRCULATIONAHA.115.020789","article-title":"Thyroid function and sudden cardiac death: a prospective population-based cohort study","volume":"134","author":"Chaker","year":"2016","journal-title":"Circulation"},{"key":"2023061601041195700_dgad025-B50","doi-asserted-by":"publisher","first-page":"333","DOI":"10.2147\/COPD.S291807","article-title":"Association between thyroid function and acute exacerbation of chronic obstructive pulmonary disease","volume":"16","author":"Huang","year":"2021","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"4","key":"2023061601041195700_dgad025-B51","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1164\/ajrccm\/146.4.1025","article-title":"Respiratory muscle strength in hyperthyroidism before and after treatment","volume":"146","author":"Siafakas","year":"1992","journal-title":"Am Rev Respir Dis"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgad025\/49228753\/dgad025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/7\/e396\/50604932\/dgad025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/108\/7\/e396\/50604932\/dgad025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T02:06:44Z","timestamp":1686881204000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/108\/7\/e396\/6993130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023,1,20]]},"published-print":{"date-parts":[[2023,6,16]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgad025","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,7]]},"published":{"date-parts":[[2023,1,20]]}}}