{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:29:51Z","timestamp":1793424591652,"version":"4.5.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The National Key Research and Development Program of China is funded by Ministry of Science and Technology of the People's Republic of China","award":["2018YFC1002400"],"award-info":[{"award-number":["2018YFC1002400"]}]},{"name":"The Special Science and Technology Major Project of Hubei Province is funded by Hubei Provincial Science and Technology Department","award":["ZDZX2020000020"],"award-info":[{"award-number":["ZDZX2020000020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the real world, as well as to examine the effects of dose on patient outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A prospective, observational, posttrial study (NCT03290235).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting, participants and intervention<\/jats:title>\n                  <jats:p>Children with GHD were enrolled from 81 centers in China in 4 individual clinical trials and received weekly 0.2 mg\/kg\/wk (high-dose) or 0.1 to &amp;lt;0.2 mg\/kg\/wk (low-dose) PEG-rhGH for 30 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcomes measures<\/jats:title>\n                  <jats:p>Height SD score (Ht SDS) at 12, 24, and 36 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1170 children were enrolled in this posttrial study, with 642 patients in the high-dose subgroup and 528 in the low-dose subgroup. The Ht SDS improved significantly after treatment in the total population (P &amp;lt; 0.0001), with a mean change of 0.53 \u00b1 0.30, 0.89 \u00b1 0.48, 1.35 \u00b1 0.63, 1.63 \u00b1 0.75 at 6 months, 12 months, 24 months, and 36 months, respectively. In addition, the changes in Ht SDS from baseline were significantly improved in the high-dose subgroup compared with the low-dose subgroup at 6, 12, 24, and 36 months after treatment (all P &amp;lt; 0.05). A total of 12 (1.03%) patients developed serious adverse events. There was no serious adverse event related to the treatment, and no AEs leading to treatment discontinuation or death occurred.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PEG-rhGH showed long-term effectiveness and safety in treating children with GHD. Both dose subgroups showed promising outcomes, whereas PEG-rhGH 0.2 mg\/kg\/wk might show additional benefit.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad039","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T01:29:48Z","timestamp":1674264588000},"page":"2078-2086","source":"Crossref","is-referenced-by-count":29,"title":["Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study"],"prefix":"10.1210","volume":"108","author":[{"given":"Ling","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-4615","authenticated-orcid":false,"given":"Ke","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, National Clinical Research Center for Child Health, The Children's Hospital, Zhejiang University School of Medicine , Hangzhou 310052 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health , Beijing 100045 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feihong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Inherited Metabolic Diseases, Children's Hospital of Fudan University , Shanghai 201102 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Genetics, Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University) , Zhengzhou 450018 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University , Guangzhou 510120 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, First Hospital of Jilin University , Changchun 130021 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ningbo Women & Children's Hospital , Ningbo 315012 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Hunan Children's Hospital , Changsha 410007 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Genetics and Metabolism, Fuzhou Children's Hospital of Fujian Medical University , Fuzhou 350005 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrine Genetics and Metabolism, Chengdu Women's and Children's Center Hospital , Chengdu 610074 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Wuhu First People's Hospital , Wuhu 241000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjiang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Genetics and Endocrinology, The Second Affiliated Hospital &Yuying Children's Hospital of Wenzhou Medical University , Wenzhou 325000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Liuzhou Maternilty and Child Heulthcare Hospital , Liuzhou, Guangxi 545001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, First Affiliated Hospital of Army Medical University (Thrid Military Medical University) , Chongqing 400038 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Second Affiliated Hospital of Anhui Medical University , Hefei 230601 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, the First 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefan","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology and Genetic Metabolism, Xinhua Hospital, Shanghai Institute for Pediatric Research, School of Medicine, Shanghai Jiao Tong University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runming","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430022 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Genetic Metabolism, Maternal and Child Health-Care Hospital in Guiyang , Guiyang 550003 , 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