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This study aimed to assess longitudinal susceptibility changes in CD using quantitative susceptibility mapping (QSM) before and after resolution of hypercortisolism.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, 24 CD patients and 24 healthy controls underwent magnetic resonance imaging (MRI) with QSM. All CD patients underwent MRI scans before and after the curative operation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After resolution of hypercortisolism, irreversibly altered susceptibility values were found in the anterior cingulate cortex, frontal lobe, caudate, and red nucleus. These alterations were significantly correlated with the changes in gray matter\/white matter volumes and clinical features. Additionally, decreased susceptibility was found in several regions in CD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Chronic exposure to hypercortisolism may be related to susceptibility alterations and significantly correlated with altered brain volumes and clinical features. in CD patients. The decrease of susceptibility might suggest the involvement of the calcium deregulation in these alterations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad060","type":"journal-article","created":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T18:38:53Z","timestamp":1675276733000},"page":"2007-2015","source":"Crossref","is-referenced-by-count":4,"title":["Irreversible Alterations of Susceptibility in Cushing's Disease: A Longitudinal QSM Study"],"prefix":"10.1210","volume":"108","author":[{"given":"Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China"},{"name":"Department of Neurosurgery, Rui Jin Lu Wan Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghao","family":"Li","sequence":"additional","affiliation":[{"name":"School of Biomedical 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