{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T15:49:08Z","timestamp":1783784948998,"version":"3.55.0"},"reference-count":22,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100020323","name":"Aegerion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020323","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Amryt Pharmaceuticals"},{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Third Rock Ventures"},{"DOI":"10.13039\/100018293","name":"Amryt","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004312","name":"Lilly","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007054","name":"MSD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boehringer-Ingelheim"},{"DOI":"10.13039\/501100011725","name":"Servier","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi-Aventis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013669","name":"Ionis Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Akcea Therapeutics"},{"name":"Gemphire Therapeutics"},{"name":"GI Dynamics"},{"name":"Thera Therapeutics"},{"DOI":"10.13039\/100002491","name":"BMS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Akcea Therapeutics"},{"name":"Rhythm Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The diagnosis of familial partial lipodystrophy (FPLD) is currently made based on clinical judgment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>There is a need for objective diagnostic tools that can diagnose FPLD accurately.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We have developed a new method that uses measurements from pelvic magnetic resonance imaging (MRI) at the pubis level. We evaluated measurements from a lipodystrophy cohort (n = 59; median age [25th-75th percentiles]: 32 [24-44]; 48 females and 11 males) and age- and sex-matched controls (n = 29). Another dataset included MRIs from 289 consecutive patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Receiver operating characteristic curve analysis revealed a potential cut-point of \u226413 mm gluteal fat thickness for the diagnosis of FPLD. A combination of gluteal fat thickness \u226413 mm and pubic\/gluteal fat ratio \u22652.5 (based on a receiver operating characteristic curve) provided 96.67% (95% CI, 82.78-99.92) sensitivity and 91.38% (95% CI, 81.02-97.14) specificity in the overall cohort and 100.00% (95% CI, 87.23-100.00) sensitivity and 90.00% (95% CI, 76.34-97.21) specificity in females for the diagnosis of FPLD. When this approach was tested in a larger dataset of random patients, FPLD was differentiated from subjects without lipodystrophy with 96.67% (95% CI, 82.78-99.92) sensitivity and 100.00% (95% CI, 98.73-100.00) specificity. When only women were analyzed, the sensitivity and the specificity was 100.00% (95% CI, 87.23-100.00 and 97.95-100.00, respectively). The performance of gluteal fat thickness and pubic\/gluteal fat thickness ratio was comparable to readouts performed by radiologists with expertise in lipodystrophy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The combined use of gluteal fat thickness and pubic\/gluteal fat ratio from pelvic MRI is a promising method to diagnose FPLD that can reliably identify FPLD in women. Our findings need to be tested in larger populations and prospectively.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgad063","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T19:26:35Z","timestamp":1677007595000},"page":"e512-e520","source":"Crossref","is-referenced-by-count":8,"title":["Pelvis Magnetic Resonance Imaging to Diagnose Familial Partial Lipodystrophy"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-9270","authenticated-orcid":false,"given":"Suleyman Cem","family":"Adiyaman","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University School of Medicine , Izmir 35330 , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-7770","authenticated-orcid":false,"given":"Canan","family":"Altay","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dokuz Eylul University School of Medicine , Izmir 35330 , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9815-9188","authenticated-orcid":false,"given":"Berfu Y","family":"Kamisli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dokuz Eylul University School of Medicine , Izmir 35330 , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-2864","authenticated-orcid":false,"given":"Emre Ruhat","family":"Avci","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dokuz Eylul University School of Medicine , Izmir 35330 , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0786-1490","authenticated-orcid":false,"given":"Isil","family":"Basara","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dokuz Eylul University School of Medicine , Izmir 35330 , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-8499","authenticated-orcid":false,"given":"Ilgin Yildirim","family":"Simsir","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Internal Medicine, Ege University School of Medicine , Izmir 35030 , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-3872","authenticated-orcid":false,"given":"Tahir","family":"Atik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Genetics, Ege University School of Medicine , Izmir 35030 , 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