{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:22:26Z","timestamp":1788218546036,"version":"build-2803163510"},"reference-count":34,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>The contribution of [18F]F-fluorocholine (FCH)-positron emission tomography (PET)\/computed tomography (CT) in normocalcemic primary hyperparathyroidism (nPHPT) remains unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the sensitivity and specificity of FCH-PET\/CT in a cohort of osteoporotic patients with nPHPT and discordant or negative [99mTc]Tc-sestamibi scintigraphy and ultrasonography who all underwent parathyroidectomy (PTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal retrospective cohort study in patients referred for osteoporosis with mild biological primary hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tertiary referral center with expertise in bone metabolism and surgical management of hyperparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Among 109 patients with PHPT analyzed, 3 groups were individualized according to total serum calcium (tCa) and ionized calcium (iCa): 32 patients with hypercalcemia (HtCa group), 39 patients with normal tCa and elevated iCa (NtCa group), and 38 patients with both normal tCa and iCa (NiCa). All patients had biochemical follow-up confirming or not the success of PTX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>To evaluate the performance of FCH-PET\/CT in terms of sensitivity and specificity, and to compare with first-line imaging procedures in the setting of nPHPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The sensitivity of FCH-PET\/CT was 67% in the hypercalcemic group, 48% in the NtCa group (P = .05 vs HtCa), and 33% in the NiCa group (P = .004 vs HtCa). Specificity ranged from 97% to 99%. FCH-PET\/CT was positive in 64.3% of patients with negative conventional imaging, with biochemical resolution after PTX in 77.8% of patients. Triple negative imaging was observed in 20 patients, with PHPT resolution in 85% of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the contribution of FCH-PET\/CT in a well-phenotyped cohort of normocalcemic patients with discordant or negative findings in [99mTc]Tc-sestamibi scintigraphy and ultrasonography. However, negative imaging in nPHPT does not rule out the possibility of surgical cure by an experienced surgeon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgad073","type":"journal-article","created":{"date-parts":[[2023,2,7]],"date-time":"2023-02-07T20:41:38Z","timestamp":1675802498000},"page":"1958-1967","source":"Crossref","is-referenced-by-count":22,"title":["FCH-PET\/CT in Primary Hyperparathyroidism With Discordant\/Negative MIBI Scintigraphy and Ultrasonography"],"prefix":"10.1210","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8237-7386","authenticated-orcid":false,"given":"Eugenie","family":"Koumakis","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Cochin Hospital, APHP , Paris 75014 , France"},{"name":"Department of Rhumatology, Centre De R\u00e9f\u00e9rence des Maladies Rares du Calcium et du Phosphate , Paris 75014 , 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